PDB ID 1AGR     CHAIN A
Protein name GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)
Uniprot Accession P10824
The number of similar proteins 57
The number of binding states 8
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AGR (CHAIN: A)
1 P49799  
2 Monomeric state
3 B1H241  
4 P62871  
5 P10824  
6 O43566  
7 Q3V6T2  
8 P62873   6CRK   P59768  

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Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GCTLSAEDKA   AVERSKMIDR   NLREDGEKAA   REVKLLLLGA   GESGKSTIVK   50
51   QMKIIHEAGY   SEEECKQYKA   VVYSNTIQSI   IAIIRAMGRL   KIDFGDAARA   100
101   DDARQLFVLA   GAAEEGFMTA   ELAGVIKRLW   KDSGVQACFN   RSREYQLNDS   150
151   AAYYLNDLDR   IAQPNYIPTQ   QDVLRTRVKT   TGIVETHFTF   KDLHFKMFDV   200
201   GGQRSERKKW   IHCFEGVTAI   IFCVALSDYD   LVLAEDEEMN   RMHESMKLFD   250
251   SICNNKWFTD   TSIILFLNKK   DLFEEKIKKS   PLTICYPEYA   GSNTYEEAAA   300
301   YIQCQFEDLN   KRKDTKEIYT   HFTCATDTKN   VQFVFDAVTD   VIIKNNLKDC   350
351   GLF           400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
21_ARG HIS gnomAD
chr1:110091404 		rs758232853
- 0.000390908 -
40_GLY ARG ClinVar
chr1:110091460 		rs387907178
Pathogenic - Auriculocondylar syndrome 1 [MONDO:MONDO:0011234,MedGen:C4551996,OMIM:602483,Orphanet:137888]
40_GLY CYS ClinVar
chr7:79764594 		rs2116052322
Likely pathogenic - Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
40_GLY VAL ClinVar
chr1:110116359 		-
Likely pathogenic - not provided [MedGen:C3661900]
40_GLY ARG ClinVar
chr7:79764594 		-
Pathogenic - not provided [MedGen:CN517202]
45_GLY ASP ClinVar
chr7:79818282 		-
Likely pathogenic - Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
47_SER ARG ClinVar
chr1:110116381 		rs397514768
Pathogenic - Auriculocondylar syndrome 1 [MONDO:MONDO:0011234,MedGen:C4551996,OMIM:602483,Orphanet:137888]
48_THR LYS ClinVar
chr7:79818291 		rs1788434338
Likely pathogenic - Neurodevelopmental disorder|Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0700092,MeSH:D065886,MedGen:C1535926|MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
48_THR ASN ClinVar
chr1:110116383 		rs1648666311
Likely pathogenic - not provided [MedGen:C3661900]
48_THR PRO ClinVar
chr7:79818290 		rs1788434297
Likely pathogenic - Seizure [Human Phenotype Ontology:HP:0001250,Human Phenotype Ontology:HP:0001275,Human Phenotype Ontology:HP:0001303,Human Phenotype Ontology:HP:0002125,Human Phenotype Ontology:HP:0002182,Human Phenotype Ontology:HP:0002279,Human Phenotype Ontology:HP:0002306,Human Phenotype Ontology:HP:0002348,Human Phenotype Ontology:HP:0002391,Human Phenotype Ontology:HP:0002417,Human Phenotype Ontology:HP:0002430,Human Phenotype Ontology:HP:0002431,Human Phenotype Ontology:HP:0002432,Human Phenotype Ontology:HP:0002434,Human Phenotype Ontology:HP:0002437,Human Phenotype Ontology:HP:0002466,Human Phenotype Ontology:HP:0002479,Human Phenotype Ontology:HP:0002794,Human Phenotype Ontology:HP:0006997,Human Phenotype Ontology:HP:0010520,MedGen:C0036572]
52_GLN PRO ClinVar
chr7:79818303 		rs1788434582
Likely pathogenic - not provided [MedGen:CN517202]
67_ARG TRP 8.3kJPN
chr3:50289866 		rs782461705
- 0.0001 -
70_ARG GLN 8.3kJPN
chr3:50289876 		rs782573516
- 0.0001 -
90_ARG TRP gnomAD
chr1:110116624 		rs145097404
- 0.000216171 -
90_ARG GLN gnomAD
chr1:110116625 		rs138850957
- 0.000228925 -
90_ARG TRP 8.3kJPN
chr1:110116624 		rs145097404
- 0.004 -
94_ASP ASN gnomAD
chr3:50289947 		rs183955200
- 0.000271485 -
94_ASP GLU 8.3kJPN
chr1:110116638 		-
- 0.0001 -
96_ALA SER 8.3kJPN
chr3:50289953 		-
- 0.0001 -
96_GLY ASP 8.3kJPN
chr7:79818531 		rs1283536547
- 0.0003 -
102_ASP GLY 8.3kJPN
chr7:79828542 		-
- 0.0001 -
120_PRO LEU 8.3kJPN
chr3:50290514 		-
- 0.0001 -
125_GLY SER 8.3kJPN
chr3:50290528 		rs782437262
- 0.0001 -
126_VAL ILE gnomAD
chr3:50290531 		rs200441316
- 0.000294539 -
126_VAL ILE 8.3kJPN
chr3:50290531 		rs200441316
- 0.0024 -
127_ILE THR gnomAD
chr7:79828617 		rs35545354
- 0.00238226 -
128_ARG TRP 8.3kJPN
chr3:50290537 		rs180852414
- 0.0008 -
155_TYR ASN 8.3kJPN
chr3:50293625 		-
- 0.0001 -
156_LEU GLN 8.3kJPN
chr3:50293629 		-
- 0.0002 -
165_PRO ALA 8.3kJPN
chr7:79833051 		rs745806214
- 0.0001 -
170_THR ILE gnomAD
chr1:110125106 		rs61754626
- 0.000262509 -
170_THR PRO 8.3kJPN
chr1:110125105 		rs1205497380
- 0.0001 -
173_ASP VAL ClinVar
chr7:79833076 		rs2115683966
Pathogenic - not provided [MedGen:C3661900]
178_ARG HIS ClinVar
chr3:50293695 		rs137853227
Pathogenic - Adrenocortical tumor, somatic|Thecoma, somatic|Ovarian granulosa cell tumor [MedGen:C4016392|MedGen:C2750844|MONDO:MONDO:0023283,MedGen:C1370419]
178_ARG GLY ClinVar
chr3:50293694 		rs137853226
Pathogenic - Pituitary dependent hypercortisolism [MONDO:MONDO:0009050,MedGen:C0221406,OMIM:219090,Orphanet:96253]
181_THR PRO ClinVar
chr3:50293703 		-
Likely pathogenic - 6 conditions [6 conditions]
199_PHE LEU ClinVar
chr3:50294161 		rs137853228
Pathogenic - Ventricular tachycardia, somatic [MedGen:C4016143]
204_GLN ARG ClinVar
chr7:79840305 		-
Likely pathogenic - Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
224_CYS TYR ClinVar
chr7:79840365 		rs1788864590
Pathogenic - not provided|Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MedGen:C3661900|MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
264_ILE VAL gnomAD
chr1:110129420 		rs61758986
- 0.000111651 -
270_LYS ARG ClinVar
chr7:79842120 		rs2115712676
Pathogenic - Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
272_ASP ASN ClinVar
chr7:79842125 		rs2115712706
Likely pathogenic - not provided [MedGen:C3661900]
272_ASP GLY ClinVar
chr7:79842126 		rs2115712712
Pathogenic - Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
280_LYS ARG 8.3kJPN
chr7:79842150 		-
- 0.0001 -
282_PRO LEU 8.3kJPN
chr1:110129475 		rs755438174
- 0.0001 -
294_ASN LYS 8.3kJPN
chr3:50294939 		rs587647183
- 0.0001 -
310_LEU MET 8.3kJPN
chr3:50294985 		rs1327376805
- 0.0001 -
312_LYS THR 8.3kJPN
chr3:50294992 		rs1553703449
- 0.0002 -
316_THR SER gnomAD
chr3:50295004 		rs372568318
- 0.000145346 -
332_VAL GLU ClinVar
chr7:79846739 		rs2115727431
Pathogenic - Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities [MONDO:MONDO:0859243,MedGen:C5676975,OMIM:619854]
346_ASN LYS 8.3kJPN
chr7:79846782 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.