PDB ID 1AGR CHAIN A
Protein name GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)
Uniprot Accession P10824
The number of similar proteins 56
The number of binding states 6
The number of binding partners 6
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1AGR (CHAIN: A)
1 P49799  
2 Monomeric state
3 P62871  
4 P10824  
5 O43566  
6 P62873   6CRK  

P59768  
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partners
  5
  4
  3
  2
  1
  0
Sequence information
1   GCTLSAEDKA   AVERSKMIDR   NLREDGEKAA   REVKLLLLGA   GESGKSTIVK   50
51   QMKIIHEAGY   SEEECKQYKA   VVYSNTIQSI   IAIIRAMGRL   KIDFGDAARA   100
101   DDARQLFVLA   GAAEEGFMTA   ELAGVIKRLW   KDSGVQACFN   RSREYQLNDS   150
151   AAYYLNDLDR   IAQPNYIPTQ   QDVLRTRVKT   TGIVETHFTF   KDLHFKMFDV   200
201   GGQRSERKKW   IHCFEGVTAI   IFCVALSDYD   LVLAEDEEMN   RMHESMKLFD   250
251   SICNNKWFTD   TSIILFLNKK   DLFEEKIKKS   PLTICYPEYA   GSNTYEEAAA   300
301   YIQCQFEDLN   KRKDTKEIYT   HFTCATDTKN   VQFVFDAVTD   VIIKNNLKDC   350
351   GLF           400
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
40_GLY ARG ClinVar
chr1:110091460
rs387907178 Pathogenic Auriculocondylar syndrome 1 [MedGen:C4551996,OMIM:602483]
47_SER ARG ClinVar
chr1:110116381
rs397514768 Pathogenic Auriculocondylar syndrome 1 [MedGen:C4551996,OMIM:602483]
178_ARG CYS ClinVar
chr3:50293694
rs137853226 Pathogenic Adrenocortical tumor, somatic [MedGen:C4016392]; Granulosa cell tumor of the ovary [MedGen:C1370419]; Thecoma, somatic [MedGen:C2750844]
178_ARG HIS ClinVar
chr3:50293695
rs137853227 Pathogenic Adrenocortical tumor, somatic [MedGen:C4016392]; Granulosa cell tumor of the ovary [MedGen:C1370419]; Thecoma, somatic [MedGen:C2750844]
178_ARG GLY ClinVar
chr3:50293694
rs137853226 Pathogenic Pituitary dependent hypercortisolism [MedGen:C0221406,OMIM:219090,SNOMED CT:190502001]
199_PHE LEU ClinVar
chr3:50294161
rs137853228 Pathogenic Ventricular tachycardia, somatic [MedGen:C4016143]