PDB ID 1AKB     CHAIN A
Protein name ASPARTATE AMINOTRANSFERASE
Uniprot Accession P00508
The number of similar proteins 23
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1AKB (CHAIN: A)
1 Monomeric state
2 P00508  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   SSWWSHVEMG   PPDPILGVTE   AFKRDTNSKK   MNLGVGAYRD   DNGKPYVLNC   50
51   VRKAEAMIAA   KKMDKEYLPI   AGLADFTRAS   AELALGENSE   AFKSGRYVTV   100
101   QGISGTGSLR   VGANFLQRFF   KFSRDVYLPK   PSWGNHTPIF   RDAGLQLQAY   150
151   RYYDPKTCSL   DFTGAMEDIS   KIPEKSIILL   HACAHNPTGV   DPRQEQWKEL   200
201   ASVVKKRNLL   AYFDMAYQGF   ASGDINRDAW   ALRHFIEQGI   DVVLSQSYAH   250
251   NMGLYGERAG   AFTVICRDAE   EAKRVESQLK   ILIRPMYSNP   PMNGARIASL   300
301   ILNTPELRKE   WLVEVKGMAD   RIISMRTQLV   SNLKKEGSSH   NWQHITDQIG   350
351   MFCFTGLKPE   QVERLTKEFS   IYMTKDGRIS   VAGVASSNVG   YLAHAIHQVT   400
401   K           450

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
7_THR SER 8.3kJPN
chr16:58757795
-
- 0.0001 -
23_ALA GLY 8.3kJPN
chr16:58757747
rs771477611
- 0.0002 -
26_ARG TRP gnomAD
chr16:58757739
rs147242485
- 0.000155184 -
38_GLY CYS 8.3kJPN
chr16:58757703
-
- 0.0001 -
41_ARG TRP gnomAD
chr16:58757694
rs557150117
- 0.000115344 -
49_VAL ILE gnomAD
chr16:58757670
rs144716246
- 0.000278485 -
49_VAL ILE 8.3kJPN
chr16:58757670
rs144716246
- 0.0002 -
51_PRO LEU gnomAD
chr16:58757663
rs765537389
- 0.000103464 -
62_ALA SER gnomAD
chr16:58756164
rs137905758
- 0.0001193 -
62_ALA THR 8.3kJPN
chr16:58756164
-
- 0.0001 -
64_ASN LYS 8.3kJPN
chr16:58756156
-
- 0.0001 -
93_GLU LYS 8.3kJPN
chr16:58756074
rs756305221
- 0.0001 -
97_SER ARG 8.3kJPN
chr16:58756060
-
- 0.0001 -
130_ASP ASN gnomAD
chr16:58752568
rs78784246
- 0.00401107 -
156_GLN LEU 8.3kJPN
chr16:58752498
-
- 0.0002 -
159_ARG GLN 8.3kJPN
chr16:58752489
rs773502230
- 0.0004 -
159_ARG TRP 8.3kJPN
chr16:58752490
rs373294477
- 0.0001 -
163_PRO LEU 8.3kJPN
chr16:58752477
rs772294547
- 0.0002 -
167_GLY SER gnomAD
chr16:58752466
rs11076256
- 0.061211 -
167_GLY SER 8.3kJPN
chr16:58752466
rs11076256
- 0.0029 -
171_THR ARG 8.3kJPN
chr16:58752453
-
- 0.0001 -
173_ALA THR gnomAD
chr16:58752448
rs201083152
- 0.000103914 -
173_ALA THR 8.3kJPN
chr16:58752448
rs201083152
- 0.0003 -
176_ASP ASN gnomAD
chr16:58752439
rs149988435
- 0.000826358 -
180_ILE THR 8.3kJPN
chr16:58752200
-
- 0.0001 -
201_ARG HIS gnomAD
chr16:58752137
rs139235307
- 0.0131535 -
219_ALA VAL 8.3kJPN
chr16:58750701
rs754471368
- 0.0001 -
225_TYR HIS 8.3kJPN
chr16:58750684
-
- 0.0001 -
241_ARG GLY ClinVar
chr16:58750636
rs752927520
Likely pathogenic - Early infantile epileptic encephalopathy with suppression bursts|Developmental and epileptic encephalopathy, 82 [MONDO:MONDO:0100062,MedGen:C0393706,OMIM:PS308350,Orphanet:1934|MONDO:MONDO:0032880,MedGen:C5231473,OMIM:618721]
245_GLU GLN 8.3kJPN
chr16:58750624
rs368352559
- 0.0001 -
247_GLY ASP 8.3kJPN
chr16:58750617
rs777180671
- 0.0002 -
304_ARG TRP 8.3kJPN
chr16:58749964
rs1406591910
- 0.0001 -
316_ARG GLY ClinVar
chr16:58749928
rs1247507359
Likely pathogenic - Early infantile epileptic encephalopathy with suppression bursts|Developmental and epileptic encephalopathy, 82 [MONDO:MONDO:0100062,MedGen:C0393706,OMIM:PS308350,Orphanet:1934|MONDO:MONDO:0032880,MedGen:C5231473,OMIM:618721]
325_VAL GLY gnomAD
chr16:58743454
rs30842
- 0.711896 -
325_VAL GLY 8.3kJPN
chr16:58743454
rs30842
- 0.617 -
329_ARG CYS 8.3kJPN
chr16:58743443
rs1465507115
- 0.0001 -
334_ARG GLN 8.3kJPN
chr16:58743427
rs752127201
- 0.0001 -
336_GLN GLU gnomAD
chr16:58743422
rs112943773
- 0.000115346 -
342_LYS ARG 8.3kJPN
chr16:58743403
-
- 0.0001 -
343_LYS GLU gnomAD
chr16:58743401
rs150122367
- 0.000767499 -
343_LYS GLU 8.3kJPN
chr16:58743401
rs150122367
- 0.007 -
345_GLY VAL ClinVar
chr16:58743394
rs1597696047
Likely pathogenic - Early infantile epileptic encephalopathy with suppression bursts|Developmental and epileptic encephalopathy, 82 [MONDO:MONDO:0100062,MedGen:C0393706,OMIM:PS308350,Orphanet:1934|MONDO:MONDO:0032880,MedGen:C5231473,OMIM:618721]
372_ARG GLN gnomAD
chr16:58742190
rs151225545
- 0.000207495 -
372_ARG TRP gnomAD
chr16:58742191
rs141302038
- 0.000291615 -
384_ASP GLY 8.3kJPN
chr16:58742154
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.