PDB ID 1ALY CHAIN A
Protein name CD40 LIGAND
Uniprot Accession P29965
The number of similar proteins 11
The number of binding states 5
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Downdload
 Format:  
Molecule viewer
#binding
partners
  4
  3
  2
  1
  0
Sequence information
1   GDQNPQIAAH   VISEASSKTT   SVLQWAEKGY   YTMSNNLVTL   ENGKQLTVKR   50
51   QGLYYIYAQV   TFCSNREASS   QAPFIASLCL   KSPGRFERIL   LRAANTHSSA   100
101   KPCGQQSIHL   GGVFELQPGA   SVFVNVTDPS   QVSHGTGFTS   FGLLKL   150
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
116_GLY ARG VAR_017929 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
116_GLY SER VAR_017930 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
123_ALA GLU ClinVar
chrX:135738536
rs104894778 Pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
125_HIS ARG VAR_017926 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
126_VAL ALA VAR_007515 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
126_VAL ASP VAR_017931 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
140_TRP TER ClinVar
chrX:135741207
rs104894775 Pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
140_TRP GLY ClinVar
chrX:135741206
rs104894777 Likely pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]; not provided [MedGen:CN517202]
140_TRP CYS VAR_007517 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
140_TRP ARG VAR_007519 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
141_ALA PRO ClinVar
chrX:135741209
rs1387503550 Pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
143_LYS THR VAR_017932 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
144_GLY GLU ClinVar
chrX:135741219
rs886039326 Likely pathogenic not provided [MedGen:CN517202]
147_THR ASN ClinVar
chrX:135741228
rs1057521127 Likely pathogenic not provided [MedGen:CN517202]
155_LEU PRO ClinVar
chrX:135741252
rs104894769 Pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
155_LEU GLN ClinVar
chrX:135741252
rs104894769 Likely pathogenic not provided [MedGen:CN517202]
169_TYR CYS ClinVar
chrX:135741294
rs786205606 Likely pathogenic not provided [MedGen:CN517202]
170_TYR CYS VAR_017923 rs756468554 Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
173_ALA ASP VAR_017933 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
174_GLN ARG VAR_017927 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
176_THR ILE VAR_017934 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
195_LEU PRO VAR_017935 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
208_ALA ASP VAR_017936 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
211_THR ASN VAR_007522 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
219_GLY ARG VAR_007523 rs148594123 Polymorphism -
220_GLN TER ClinVar
chrX:135741446
rs1085307733 Pathogenic not provided [MedGen:CN517202]
224_HIS TYR VAR_017937 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
226_GLY ALA VAR_017938 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
227_GLY VAL ClinVar
chrX:135741468
rs104894768 Pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
231_LEU SER VAR_007526 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
235_ALA PRO ClinVar
chrX:135741491
rs104894771 Pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
237_VAL GLU VAR_017939 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
254_THR MET ClinVar
chrX:135741549
rs193922136 Pathogenic Hyperimmunoglobulin M syndrome [MedGen:C0272236,SNOMED CT:82286005]; Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
254_THR LYS ClinVar
chrX:135741549
rs193922136 Likely pathogenic Immunodeficiency with hyper IgM type 1 [MedGen:C0398689,OMIM:308230,Orphanet:ORPHA101088]
256_PHE SER ClinVar
chrX:135741555
rs1057521128 Likely pathogenic not provided [MedGen:CN517202]
257_GLY SER VAR_017928 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
257_GLY ASP VAR_017940 rs1477466218 Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]
258_LEU SER VAR_017924 - Disease Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]