PDB ID 1APM     CHAIN E
Protein name cAMP-DEPENDENT PROTEIN KINASE
Uniprot Accession P05132
The number of similar proteins 345
The number of binding states 7
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1APM (CHAIN: E)
1 Monomeric state
2 P12367  
3 P12369  
4 P05132  
5 E9Q401  
6 P42588  
7 P31324   P31324  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GNAAAAKKGX   EQESVKEFLA   KAKEDFLKKW   ETPSQNTAQL   DQFDRIKTLG   50
51   TGSFGRVMLV   KHKESGNHYA   MKILDKQKVV   KLKQIEHTLN   EKRILQAVNF   100
101   PFLVKLEFSF   KDNSNLYMVM   EYVAGGEMFS   HLRRIGRFAE   PHARFYAAQI   150
151   VLTFEYLHSL   DLIYRDLKPE   NLLIDQQGYI   QVTDFGFAKR   VKGRTWXLCG   200
201   TPEYLAPEII   LSKGYNKAVD   WWALGVLIYE   MAAGYPPFFA   DQPIQIYEKI   250
251   VSGKVRFPSH   FSSDLKDLLR   NLLQVDLTKR   FGNLKNGVND   IKNHKWFATT   300
301   DWIAIYQRKV   EAPFIPKFKG   PGDTSNFDDY   EEEEIRVXIN   EKCGKEFTEF   350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
10_GLU LYS 8.3kJPN
chr9:71628978 		rs1286264874
- 0.0005 -
23_LYS GLU 8.3kJPN
chr19:14218198 		rs1047760101
- 0.0001 -
41_ASP ASN 8.3kJPN
chr9:71628885 		-
- 0.0001 -
43_PHE LEU 8.3kJPN
chr9:71628877 		-
- 0.0001 -
45_ARG GLN gnomAD
chr19:14217672 		rs56085217
- 0.00198091 -
45_ARG GLN 8.3kJPN
chr19:14217672 		rs56085217
- 0.0001 -
52_GLY ALA 8.3kJPN
chr9:71628851 		rs200902927
- 0.0001 -
53_SER LEU ClinVar
chr1:84647935 		rs1663748771
Pathogenic - Cardioacrofacial dysplasia 2 [MONDO:MONDO:0030877,MedGen:C5436886,OMIM:619143]
62_HIS ARG 8.3kJPN
chr1:84647962 		-
- 0.0001 -
65_THR ILE 8.3kJPN
chr9:71628812 		rs1355972241
- 0.0002 -
67_GLN HIS 8.3kJPN
chr1:84647978 		rs745646679
- 0.0005 -
73_ILE MET ClinVar
chr9:71628787 		rs724159972
Pathogenic - Platelet-type bleeding disorder 19 [MONDO:MONDO:0014518,MedGen:C4015405,OMIM:616176,Orphanet:438207]
79_VAL ALA gnomAD
chr9:71628770 		rs148063597
- 0.000342003 -
87_HIS ARG ClinVar
chr1:84649745 		rs768056300
Pathogenic - Cardioacrofacial dysplasia 2 [MONDO:MONDO:0030877,MedGen:C5436886,OMIM:619143]
87_HIS ASN ClinVar
chr1:84649744 		rs748898273
Pathogenic - Cardioacrofacial dysplasia 2 [MONDO:MONDO:0030877,MedGen:C5436886,OMIM:619143]
87_HIS LEU ClinVar
chr1:84649745 		-
Pathogenic - Cardioacrofacial dysplasia 2 [MONDO:MONDO:0030877,MedGen:C5436886,OMIM:619143]
90_ASN LYS 8.3kJPN
chr9:71628736 		rs758425612
- 0.0001 -
93_ARG GLY 8.3kJPN
chr9:71628729 		-
- 0.0001 -
105_ARG GLN gnomAD
chr1:84649799 		rs36117118
- 0.000154803 -
136_GLY ARG ClinVar
chr19:14211648 		rs148280386
Pathogenic/Likely pathogenic - Cardioacrofacial dysplasia 1|not provided [MONDO:MONDO:0030876,MedGen:C5436885,OMIM:619142|MedGen:CN517202]
136_GLY ARG 8.3kJPN
chr9:71628600 		rs571783065
- 0.0001 -
147_ALA THR 8.3kJPN
chr19:14208680 		rs1192231636
- 0.0001 -
151_VAL ILE 8.3kJPN
chr19:14208668 		rs1271103680
- 0.0001 -
165_ARG CYS 8.3kJPN
chr9:71628513 		-
- 0.0001 -
196_TRP ARG 8.3kJPN
chr1:84663454 		rs772092967
- 0.0001 -
205_LEU ARG ClinVar
chr19:14208416 		rs386352352
Pathogenic/Likely pathogenic - not provided|Pigmented nodular adrenocortical disease, primary, 4|ACTH-independent adrenal Cushing syndrome, somatic [MedGen:C3661900|MONDO:MONDO:0014359,MedGen:C4014425,OMIM:615830,Orphanet:189439|MONDO:MONDO:0800377,MedGen:CN322664]
223_ALA ASP 8.3kJPN
chr9:71628338 		rs778655344
- 0.0001 -
234_GLY ARG ClinVar
chr1:84668426 		rs1670492319
Pathogenic - Cardioacrofacial dysplasia 2 [MONDO:MONDO:0030877,MedGen:C5436886,OMIM:619143]
246_ILE SER 8.3kJPN
chr9:71628269 		-
- 0.0001 -
265_LEU PHE gnomAD
chr9:71628213 		rs202063130
- 0.000119322 -
265_LEU PHE 8.3kJPN
chr9:71628213 		rs202063130
- 0.001 -
267_HIS ASP gnomAD
chr9:71628207 		rs3730386
- 0.268079 -
267_HIS ASP 8.3kJPN
chr9:71628207 		rs3730386
- 0.2337 -
274_GLN TER 8.3kJPN
chr9:71628186 		-
- 0.0001 -
293_ASN SER 8.3kJPN
chr19:14204489 		-
- 0.0001 -
295_LYS ARG gnomAD
chr9:71628122 		rs146127115
- 0.000119288 -
299_THR MET gnomAD
chr1:84679969 		rs143624941
- 0.000677373 -
308_LYS ARG gnomAD
chr9:71628083 		rs112974235
- 0.00021472 -
319_THR SER 8.3kJPN
chr9:71628051 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.