PDB ID 1AQ1     CHAIN A
Protein name CYCLIN-DEPENDENT PROTEIN KINASE 2
Uniprot Accession P24941
The number of similar proteins 456
The number of binding states 12
The number of binding partners 10

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AQ1 (CHAIN: A)
1 Monomeric state
2 P61024  
3 P89883  
4 P20248  
5 Q5MJ70  
6 Q16667  
7 Q5MJ70   P46527  
8 P20248   P46527  
9 P20248   Q99741  
10 O94901   Q5MJ70  
11 P24941   P20248  
12 P24941   P20248   P20248  

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Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MENFQKVEKI   GEGTYGVVYK   ARNKLTGEVV   ALKKIRLDTE   TEGVPSTAIR   50
51   EISLLKELNH   PNIVKLLDVI   HTENKLYLVF   EFLHQDLKKF   MDASALTGIP   100
101   LPLIKSYLFQ   LLQGLAFCHS   HRVLHRDLKP   QNLLINTEGA   IKLADFGLAR   150
151   AFGVPVRTYT   HEVVTLWYRA   PEILLGCKYY   STAVDIWSLG   CIFAEMVTRR   200
201   ALFPGDSEID   QLFRIFRTLG   TPDEVVWPGV   TSMPDYKPSF   PKWARQDFSK   250
251   VVPPLDEDGR   SLLSQMLHYD   PNKRISAKAA   LAHPFFQDVT   KPVPHLRL   300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
3_ASN LYS gnomAD
chr12:56360801 		rs139342756
- 0.000510365 -
15_TYR SER VAR_016157 rs3087335
LB/B - -
18_VAL LEU VAR_053927 rs11554376
LB/B - -
45_PRO LEU VAR_041972 -
US - A glioblastoma multiforme sample
77_TYR HIS 8.3kJPN
chr12:56361867 		rs1325392225
- 0.0001 -
109_PHE LEU 8.3kJPN
chr12:56362573 		rs756703184
- 0.0006 -
200_ARG GLN 8.3kJPN
chr12:56364838 		rs763512696
- 0.0001 -
210_ASP ALA 8.3kJPN
chr12:56364868 		-
- 0.0001 -
214_ARG GLN 8.3kJPN
chr12:56364880 		-
- 0.0001 -
231_THR ASN 8.3kJPN
chr12:56364931 		-
- 0.0001 -
245_ARG GLN gnomAD
chr12:56364973 		rs144092294
- 0.000222668 -
245_ARG TRP 8.3kJPN
chr12:56364972 		rs868674487
- 0.0002 -
245_ARG GLN 8.3kJPN
chr12:56364973 		rs144092294
- 0.0019 -
255_LEU VAL 8.3kJPN
chr12:56365002 		rs1359177454
- 0.0003 -
256_ASP ASN 8.3kJPN
chr12:56365005 		-
- 0.0001 -
260_ARG GLN 8.3kJPN
chr12:56365018 		rs774683147
- 0.0001 -
270_ASP ASN 8.3kJPN
chr12:56365320 		rs759820038
- 0.0001 -
290_THR SER VAR_019988 rs2069413
LB/B - -
290_THR SER gnomAD
chr12:56365381 		rs2069413
- 0.00232636 -
290_THR SER 8.3kJPN
chr12:56365381 		rs2069413
- 0.0069 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.