PDB ID 1ARL     CHAIN A
Protein name APO-CARBOXYPEPTIDASE A=ALPHA= (COX)
Uniprot Accession P00730
The number of similar proteins 39
The number of binding states 7
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1ARL (CHAIN: A)
1 Monomeric state
2 58374130  
3 P00730  
4 P01075  
5 P00730   P00730  
6 1PYT   P00730  
7 P00730   P81511   P81511  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   ARSTNTFNYA   TYHTLDEIYD   FMDLLVAEHP   QLVSKLQIGR   SYEGRPIYVL   50
51   KFSTGGSNRP   AIWIDLGIHS   REWITQATGV   WFAKKFTEDY   GQDPSFTAIL   100
101   DSMDIFLEIV   TNPDGFAFTH   SQNRLWRKTR   SVTSSSLCVG   VDANRNWDAG   150
151   FGKAGASSSP   CSETYHGKYA   NSEVEVKSIV   DFVKDHGNFK   AFLSIHSYSQ   200
201   LLLYPYGYTT   QSIPDKTELN   QVAKSAVAAL   KSLYGTSYKY   GSIITTIYQA   250
251   SGGSIDWSYN   QGIKYSFTFE   LRDTGRYGFL   LPASQIIPTA   QETWLGVLTI   300
301   MEHTVNN           350

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
5_ASP ASN 8.3kJPN
chr7:130021666
rs782573440
- 0.0008 -
14_THR ILE gnomAD
chr7:130021694
rs150653308
- 0.00186315 -
27_ALA GLY gnomAD
chr7:130021977
rs183429188
- 0.000183007 -
27_ALA GLY 8.3kJPN
chr7:130021977
rs183429188
- 0.0024 -
30_PRO ARG 8.3kJPN
chr7:130021986
-
- 0.0005 -
54_THR MET 8.3kJPN
chr7:130023239
rs781903028
- 0.0001 -
56_GLY ASP gnomAD
chr7:130023245
rs144546424
- 0.00171453 -
59_ARG HIS gnomAD
chr7:130023254
rs114365673
- 0.000334648 -
59_ARG HIS 8.3kJPN
chr7:130023254
rs114365673
- 0.0001 -
71_ARG GLN 8.3kJPN
chr7:130023290
rs377042960
- 0.0001 -
92_GLN LYS gnomAD
chr7:130023543
rs61735962
- 0.0011059 -
98_ALA THR gnomAD
chr7:130023561
rs34474469
- 0.0260035 -
110_VAL ILE 8.3kJPN
chr7:130023597
-
- 0.0002 -
146_ASN LYS ClinVar
chr7:130024448
rs1796449608
Likely pathogenic - not provided [MedGen:C3661900]
159_ASN LYS 8.3kJPN
chr7:130025006
rs782284797
- 0.0001 -
160_PRO LEU 8.3kJPN
chr7:130025008
-
- 0.0001 -
172_SER PRO ClinVar
chr7:130025043
-
Likely pathogenic - not provided [MedGen:C3661900]
231_ALA THR gnomAD
chr7:130025713
rs77792157
- 0.000183034 -
231_ALA THR 8.3kJPN
chr7:130025713
rs77792157
- 0.0569 -
252_GLY GLU ClinVar
chr7:130027677
rs2117509052
Likely pathogenic - not provided [MedGen:C3661900]
255_ILE THR 8.3kJPN
chr7:130027686
-
- 0.0001 -
272_ARG GLN 8.3kJPN
chr7:130027737
rs782284762
- 0.0001 -
276_ARG CYS gnomAD
chr7:130027748
rs201750163
- 0.000131252 -
276_ARG CYS 8.3kJPN
chr7:130027748
rs201750163
- 0.0001 -
293_THR MET 8.3kJPN
chr7:130027800
rs141400125
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.