PDB ID 1BE3     CHAIN A
Protein name CYTOCHROME BC1 COMPLEX
Uniprot Accession P31800
The number of similar proteins 36
The number of binding states 9
The number of binding partners 9

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   TATYAQALQS   VPETQVSQLD   NGLRVASEQS   SQPTCTVGVW   IDAGSRYESE   50
51   KNNGAGYFVE   HLAFKGTKNR   PGNALEKEVE   SMGAHLNAYS   TREHTAYYIK   100
101   ALSKDLPKAV   ELLADIVQNC   SLEDSQIEKE   RDVILQELQE   NDTSMRDVVF   150
151   NYLHATAFQG   TPLAQSVEGP   SENVRKLSRA   DLTEYLSRHY   KAPRMVLAAA   200
201   GGLEHRQLLD   LAQKHFSGLS   GTYDEDAVPT   LSPCRFTGSQ   ICHREDGLPL   250
251   AHVAIAVEGP   GWAHPDNVAL   QVANAIIGHY   DCTYGGGAHL   SSPLASIAAT   300
301   NKLCQSFQTF   NICYADTGLL   GAHFVCDHMS   IDDMMFVLQG   QWMRLCTSAT   350
351   ESEVLRGKNL   LRNALVSHLD   GTTPVCEDIG   RSLLTYGRRI   PLAEWESRIA   400
401   EVDARVVREV   CSKYFYDQCP   AVAGFGPIEQ   LPDYNRIRSG   MFWLRF   450

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
17_SER GLY gnomAD
chr3:48646654 		rs117171524
- 0.000754354 -
17_SER GLY 8.3kJPN
chr3:48646654 		rs117171524
- 0.0001 -
20_ASP GLU 8.3kJPN
chr3:48646643 		-
- 0.0001 -
55_ALA SER gnomAD
chr3:48643235 		rs201250580
- 0.000199149 -
86_LEU PRO ClinVar
chr3:48642152 		-
Likely pathogenic - Parkinsonism with polyneuropathy [MONDO:MONDO:0036193,MedGen:C5543299,OMIM:619279,Orphanet:611237]
181_ASP HIS gnomAD
chr3:48641060 		rs17080284
- 0.00222461 -
181_ASP HIS 8.3kJPN
chr3:48641060 		rs17080284
- 0.0359 -
212_ALA THR gnomAD
chr3:48638871 		rs145767014
- 0.000119379 -
227_ALA THR 8.3kJPN
chr3:48638826 		-
- 0.0001 -
232_THR SER 8.3kJPN
chr3:48638811 		-
- 0.0001 -
233_PRO ARG gnomAD
chr3:48638807 		rs149245457
- 0.00313314 -
233_PRO ARG 8.3kJPN
chr3:48638807 		rs149245457
- 0.0027 -
235_ARG HIS gnomAD
chr3:48638801 		rs62618742
- 0.0168131 -
235_ARG CYS gnomAD
chr3:48638802 		rs533718471
- 0.000131387 -
242_ARG CYS ClinVar
chr3:48638548 		rs201911056
Likely pathogenic - Hypertrophic cardiomyopathy [Human Phenotype Ontology:HP:0001639,MONDO:MONDO:0005045,MeSH:D002312,MedGen:C0007194,Orphanet:217569]
242_ARG CYS 8.3kJPN
chr3:48638548 		rs201911056
- 0.0001 -
267_ASN SER gnomAD
chr3:48638472 		rs144710790
- 0.00233837 -
274_ASN SER gnomAD
chr3:48638451 		rs187641562
- 0.000319415 -
274_ASN SER 8.3kJPN
chr3:48638451 		rs187641562
- 0.0003 -
277_ILE LEU ClinVar
chr3:48638443 		rs2107843274
Pathogenic - Parkinsonism with polyneuropathy [MONDO:MONDO:0036193,MedGen:C5543299,OMIM:619279,Orphanet:611237]
278_GLY SER gnomAD
chr3:48638440 		rs145869559
- 0.00045596 -
280_TYR SER ClinVar
chr3:48638433 		rs780978963
Pathogenic - Parkinsonism with polyneuropathy [MONDO:MONDO:0036193,MedGen:C5543299,OMIM:619279,Orphanet:611237]
281_ASP GLY 8.3kJPN
chr3:48638430 		-
- 0.0001 -
304_CYS TYR 8.3kJPN
chr3:48638227 		-
- 0.0001 -
316_GLU VAL 8.3kJPN
chr3:48638191 		-
- 0.0001 -
340_GLY ARG 8.3kJPN
chr3:48638120 		rs139928470
- 0.0001 -
356_ARG GLN gnomAD
chr3:48637959 		rs777309520
- 0.000111346 -
380_GLY ARG 8.3kJPN
chr3:48637558 		-
- 0.0001 -
381_ARG CYS 8.3kJPN
chr3:48637555 		rs370334893
- 0.0001 -
388_ARG CYS 8.3kJPN
chr3:48637534 		rs780875481
- 0.0001 -
408_ARG CYS 8.3kJPN
chr3:48637122 		rs762050976
- 0.0001 -
425_TYR ASN gnomAD
chr3:48637071 		rs202030377
- 0.000226902 -
440_GLY SER 8.3kJPN
chr3:48636584 		rs1393314057
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.