PDB ID 1BG3 CHAIN A
Protein name HEXOKINASE
Uniprot Accession P05708
The number of similar proteins 16
The number of binding states 2
The number of binding partners 1
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1BG3 (CHAIN: A)
1 Monomeric state
2 P19367  
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partners
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Sequence information
1   MIAAQLLAYY   FTELKDDQVK   KIDKYLYAMR   LSDEILIDIL   TRFKKEMKNG   50
51   LSRDYNPTAS   VKMLPTFVRS   IPDGSEKGDF   IALDLGGSSF   RILRVQVNHE   100
101   KNQNVSMESE   IYDTPENIVH   GSGTQLFDHV   ADCLGDFMEK   KKIKDKKLPV   150
151   GFTFSFPCRQ   SKIDEAVLIT   WTKRFKASGV   EGADVVKLLN   KAIKKRGDYD   200
201   ANIVAVVNDT   VGTMMTCGYD   DQQCEVGLII   GTGTNACYME   ELRHIDLVEG   250
251   DEGRMCINTE   WGAFGDDGSL   EDIRTEFDRE   LDRGSLNPGK   QLFEKMVSGM   300
301   YMGELVRLIL   VKMAKEGLLF   EGRITPELLT   RGKFNTSDVS   AIEKDKEGIQ   350
351   NAKEILTRLG   VEPSDVDCVS   VQHICTIVSF   RSANLVAATL   GAILNRLRDN   400
401   KGTPRLRTTV   GVDGSLYKMH   PQYSRRFHKT   LRRLVPDSDV   RFLLSESGTG   450
451   KGAAMVTAVA   YRLAEQHRQI   EETLAHFRLS   KQTLMEVKKR   LRTEMEMGLR   500
501   KETNSKATVK   MLPSFVRSIP   DGTEHGDFLA   LDLGGTNFRV   LLVKIRSGKK   550
551   RTVEMHNKIY   SIPLEIMQGT   GDELFDHIVS   CISDFLDYMG   IKGPRMPLGF   600
601   TFSFPCHQTN   LDCGILISWT   KGFKATDCEG   HDVASLLRDA   VKRREEFDLD   650
651   VVAVVNDTVG   TMMTCAYEEP   TCEIGLIVGT   GTNACYMEEM   KNVEMVEGNQ   700
701   GQMCINMEWG   AFGDNGCLDD   IRTDFDKVVD   EYSLNSGKQR   FEKMISGMYL   750
751   GEIVRNILID   FTKKGFLFRG   QISEPLKTRG   IFETKFLSQI   ESDRLALLQV   800
801   RAILQQLGLN   STCDDSILVK   TVCGVVSKRA   AQLCGAGMAA   VVEKIRENRG   850
851   LDHLNVTVGV   DGTLYKLHPH   FSRIMHQTVK   ELSPKCTVSF   LLSEDGSGKG   900
901   AALITAVGVR   LRGDPSIA         950
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
414_GLY GLU ClinVar
chr10:71139827
rs1064795154 Likely pathogenic not provided [MedGen:CN517202]
445_SER LEU ClinVar
chr10:71142311
rs1064794848 Likely pathogenic not provided [MedGen:CN517202]
457_THR MET ClinVar
chr10:71142347
rs1057517928 Likely pathogenic not provided [MedGen:CN517202]
529_LEU SER ClinVar
chr10:71144104
rs137853249 Pathogenic Hemolytic anemia due to hexokinase deficiency [MedGen:C3150343,OMIM:235700,SNOMED CT:191177007]
680_THR SER ClinVar
chr10:71151884
rs398122379 Pathogenic Hemolytic anemia due to hexokinase deficiency [MedGen:C3150343,OMIM:235700,SNOMED CT:191177007]
847_GLU LYS ClinVar
chr10:71158514
rs777849213 Pathogenic Retinitis pigmentosa 79 [MedGen:C4479526,OMIM:617460]