PDB ID 1BJ4     CHAIN A
Protein name Serine hydroxymethyltransferase, cytosolic
Uniprot Accession P34896
The number of similar proteins 20
The number of binding states 3
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BJ4 (CHAIN: A)
1 Monomeric state
2 P07511  
3 P34896   P34896  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   DADLWSSHDK   MLAQPLKDSD   VEVYNIIKKE   SNRQRVGLEL   IASENFASRA   50
51   VLEALGSCLN   NKYSEGYPGQ   RYYGGTEFID   ELETLCQKRA   LQAYKLDPQC   100
101   WGVNVQPYSG   SPANFAVYTA   LVEPHGRIMG   LDLPDGGHLT   HGFMTDKKKI   150
151   SATSIFFESM   PYKVNPDTGY   INYDQLEENA   RLFHPKLIIA   GTSCYSRNLE   200
201   YARLRKIADE   NGAYLMADMA   HISGLVAAGV   VPSPFEHCHV   VTTTTHKTLR   250
251   GCRAGMIFYR   KGVKSVDPKT   GKEILYNLES   LINSAVFPGL   QGGPHNHAIA   300
301   GVAVALKQAM   TLEFKVYQHQ   VVANCRALSE   ALTELGYKIV   TGGSDNHLIL   350
351   VDLRSKGTDG   GRAEKVLEAC   SIACNKNTCP   GDRSALRPSG   LRLGTPALTS   400
401   RGLLEKDFQK   VAHFIHRGIE   LTLQIQSDTG   VRATLKEFKE   RLAGDKYQAA   450
451   VQALREEVES   FASLFPLPGL         500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
13_ASP GLU 8.3kJPN
chr17:18259257 		-
- 0.0001 -
42_ASN ASP 8.3kJPN
chr17:18257104 		rs201557147
- 0.0009 -
43_ARG GLN 8.3kJPN
chr17:18257100 		rs770150583
- 0.0001 -
100_ALA THR 8.3kJPN
chr17:18251699 		-
- 0.0001 -
116_GLN ARG 8.3kJPN
chr17:18251650 		rs759784953
- 0.0002 -
137_ARG HIS 8.3kJPN
chr17:18250919 		rs766011995
- 0.0001 -
145_ASP HIS 8.3kJPN
chr17:18250896 		rs768492092
- 0.0003 -
147_GLY ASP gnomAD
chr17:18250889 		rs563467894
- 0.00029054 -
156_ASP GLU gnomAD
chr17:18250861 		rs558723951
- 0.000151173 -
191_ARG CYS gnomAD
chr17:18244076 		rs148701087
- 0.00064225 -
197_LEU PRO gnomAD
chr17:18244057 		rs73291881
- 0.000100793 -
204_CYS SER 8.3kJPN
chr17:18243561 		-
- 0.0001 -
207_ARG TER 8.3kJPN
chr17:18243552 		rs748683840
- 0.0001 -
213_ARG TRP gnomAD
chr17:18243534 		rs115185998
- 0.000330246 -
216_LYS ARG gnomAD
chr17:18243524 		rs78909145
- 0.00607471 -
216_LYS ARG 8.3kJPN
chr17:18243524 		rs78909145
- 0.0001 -
226_MET LEU 8.3kJPN
chr17:18243495 		-
- 0.003 -
240_VAL MET gnomAD
chr17:18243453 		rs150889470
- 0.000111406 -
249_HIS ARG 8.3kJPN
chr17:18243425 		-
- 0.0001 -
308_ALA VAL 8.3kJPN
chr17:18238881 		rs1262762031
- 0.0001 -
340_GLU GLN VAR_059795 rs7215148
LB/B - -
340_GLU GLN gnomAD
chr17:18236516 		rs7215148
- 0.000701564 -
349_ILE THR 8.3kJPN
chr17:18236488 		rs758066653
- 0.0001 -
364_ARG HIS gnomAD
chr17:18233949 		rs141263245
- 0.000151121 -
364_ARG CYS 8.3kJPN
chr17:18233950 		rs758472877
- 0.001 -
394_SER ASN gnomAD
chr17:18232693 		rs139056136
- 0.000111838 -
415_GLU GLY 8.3kJPN
chr17:18232630 		-
- 0.0001 -
455_ASP TYR gnomAD
chr17:18232153 		rs546838005
- 0.00022071 -
455_ASP TYR 8.3kJPN
chr17:18232153 		rs546838005
- - -
461_VAL MET 8.3kJPN
chr17:18232135 		rs769762115
- 0.0001 -
465_ARG TRP 8.3kJPN
chr17:18232123 		rs551074461
- 0.0001 -
474_LEU PHE VAR_022010 rs1979277
LB/B - -
474_LEU PHE gnomAD
chr17:18232096 		rs1979277
- 0.268191 -
474_LEU PHE 8.3kJPN
chr17:18232096 		rs1979277
- 0.0883 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.