PDB ID 1D6N CHAINA
Protein namePROTEIN (HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE)
Uniprot Accession P00492
The number of similar proteins 12
The number of binding states 3
The number of binding partners 1
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1D6N (CHAIN: A)
1 P00492
2 P00492 P00492
3 P00492 P00492 P00492
Downdload
Format:
Molecule viewer
#binding
partners
  1
  0
Sequence information
1  SPGVVISDDE   PGYDLDLFCI   PNHYAEDLER   VFIPHGLIMD   RTERLARDVM   50
51  KEMGGHHIVA   LCVLAGGYKF   FADLLDYIKA   LNRNSDRSIP   MTVDFIRLGS   100
101  YCNDQSTGDI   KVIGGDDLST   LTGKNVLIVE   DIIDTGKTMQ   TLLSLVRQYN   150
151  PKMVKVASLL   VKRTPRSVGY   KPDFVGFEIP   DKFVVGYALD   YNEYFRDLNH   200
201  VCVISETGKA   KYKA                                           250
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
6_GLY ASP VAR_006750 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
7_VAL GLY VAR_006751 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
15_GLY SER VAR_006753 rs137852499 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
19_ASP VAL VAR_006754 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
22_CYS PHE VAR_071610 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
40_LEU PRO VAR_006756 rs137852480 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
41_ILE THR VAR_006758 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
43_ASP TYR VAR_071611 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
44_ARG LYS VAR_006760 rs137852491 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
47_ARG HIS VAR_006761 rs387906725 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
49_ALA PRO VAR_006763 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
50_ARG PRO VAR_006765 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
51_ASP GLY VAR_006766 rs137852502 Polymorphism -
52_VAL MET VAR_006768 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
53_MET LEU VAR_006769 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
56_MET THR VAR_006770 rs137852495 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
57_GLY ARG VAR_006771 rs137852500 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
59_HIS ARG VAR_071612 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
60_HIS ARG VAR_006772 - Unclassified -
63_ALA PRO VAR_071613 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
64_LEU PRO VAR_071614 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
69_GLY GLU VAR_006773 rs137852487 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
70_GLY ARG VAR_006774 rs137852488 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
71_TYR CYS VAR_071615 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
73_PHE LEU VAR_006775 rs137852481 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
77_LEU GLN VAR_071616 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
79_ASP VAL VAR_006777 rs137852478 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
103_SER ARG VAR_006778 rs137852485 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
109_SER LEU VAR_006779 rs137852482 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
123_THR PRO VAR_071618 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
129_VAL ASP VAR_006780 rs137852483 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
130_LEU SER VAR_006781 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
131_ILE THR VAR_006783 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
134_ASP GLY VAR_006784 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
142_MET LYS VAR_006785 rs137852496 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
146_LEU PRO VAR_071619 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
158_LYS GLU VAR_071620 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
160_ALA SER VAR_006787 rs137852484 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
161_SER ARG VAR_006788 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
167_THR ILE VAR_006789 rs137852498 Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
175_PRO LEU VAR_006790 rs137852493 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
176_ASP TYR VAR_006792 rs137852492 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
182_ILE THR VAR_006796 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
184_ASP GLY VAR_071622 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
187_VAL ALA VAR_006795 - Unclassified -
191_ALA VAL VAR_071623 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
193_ASP ASN VAR_006798 rs267606863 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
194_TYR CYS VAR_006799 - Disease Gout HPRT-related (GOUT-HPRT) [MIM:300323]
198_PHE VAL VAR_006800 rs137852486 Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
200_ASP TYR VAR_006803 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
203_HIS ARG VAR_006805 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]
205_CYS TYR VAR_006806 - Disease Lesch-Nyhan syndrome (LNS) [MIM:300322]