PDB ID 1EJ9     CHAIN A
Protein name DNA TOPOISOMERASE I
Uniprot Accession P11387
The number of similar proteins 15
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1EJ9 (CHAIN: A)
1 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   WKWWEEERYP   EGIKWKFLEH   KGPVFAPPYE   PLPENVKFYY   DGKVMKLSPK   50
51   AEEVATFFAK   MLDHEYTTKE   IFRKNFFKDW   RKEMTNEEKN   IITNLSKCDF   100
101   TQMSQYFKAQ   TEARKQMSKE   EKLKIKEENE   KLLKEYGFCI   MDNHKERIAN   150
151   FKIEPPGLFR   GRGNHPKMGM   LKRRIMPEDI   IINCSKDAKV   PSPPPGHKWK   200
201   EVRHDNKVTW   LVSWTENIQG   SIKYIMLNPS   SRIKGEKDWQ   KYETARRLKK   250
251   CVDKIRNQYR   EDWKSKEMKV   RQRAVALYFI   DKLALRAGNE   KEEGETADTV   300
301   GCCSLRVEHI   NLHPELDGQE   YVVEFDFLGK   DSIRYYNKVP   VEKRVFKNLQ   350
351   LFMENKQPED   DLFDRLNTGI   LNKHLQDLME   GLTAKVFRTY   NASITLQQQL   400
401   KELTAPDENI   PAKILSYNRA   NRAVAILCNH   QIAPPKTFEK   SMMNLQTKID   450
451   AKKEQLADAR   RDLKSAKADA   KVMKDAKTKK   VVESKKKAVQ   RLEEQLMKLE   500
501   VQATDREENK   QIALGTSKLN   FLDPRITVAW   CKKWGVPIEK   IYNKTQREKF   550
551   AWAIDMADED   YEF         600

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
214_GLY SER VAR_052592 rs6029542
LB/B - -
291_LYS THR 8.3kJPN
chr20:39726874
-
- 0.0001 -
296_ASN SER gnomAD
chr20:39726889
rs144769453
- 0.000210873 -
304_GLN HIS 8.3kJPN
chr20:39726914
-
- 0.0001 -
326_LYS ARG VAR_036555 -
US - Breast cancer
335_LEU VAL 8.3kJPN
chr20:39728723
-
- 0.0001 -
370_MET THR VAR_010666 -
US - CPT-resistant leukemia
376_ARG GLN 8.3kJPN
chr20:39728847
-
- 0.0001 -
380_GLU LYS 8.3kJPN
chr20:39728858
rs756669367
- 0.0001 -
418_GLU LYS ClinVar
chr20:39729937
rs121434562
Pathogenic - DNA topoisomerase I, camptothecin-resistant [MedGen:C4016020]
452_LYS GLN 8.3kJPN
chr20:39741467
rs1265323416
- 0.0001 -
462_ARG GLY 8.3kJPN
chr20:39741497
rs777034891
- 0.0001 -
469_GLU LYS 8.3kJPN
chr20:39741518
-
- 0.0001 -
471_LYS ARG 8.3kJPN
chr20:39741525
rs765735179
- 0.0006 -
533_ASP GLY VAR_007530 rs267607131
US - CPT-resistant leukemia
546_ARG GLN 8.3kJPN
chr20:39742794
-
- 0.0001 -
596_ILE VAL 8.3kJPN
chr20:39744996
-
- 0.0001 -
722_ASN SER VAR_010667 -
US - CPT-resistant leukemia
729_THR ALA VAR_007531 -
US - CPT-resistant lung cancer
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.