PDB ID 1EJ9 CHAINA
Protein nameDNA TOPOISOMERASE I
Uniprot Accession P11387
The number of similar proteins 15
The number of binding states 1
The number of binding partners 0
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1EJ9 (CHAIN: A)
1 Monomeric state
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partners
  0
Sequence information
1  WKWWEEERYP   EGIKWKFLEH   KGPVFAPPYE   PLPENVKFYY   DGKVMKLSPK   50
51  AEEVATFFAK   MLDHEYTTKE   IFRKNFFKDW   RKEMTNEEKN   IITNLSKCDF   100
101  TQMSQYFKAQ   TEARKQMSKE   EKLKIKEENE   KLLKEYGFCI   MDNHKERIAN   150
151  FKIEPPGLFR   GRGNHPKMGM   LKRRIMPEDI   IINCSKDAKV   PSPPPGHKWK   200
201  EVRHDNKVTW   LVSWTENIQG   SIKYIMLNPS   SRIKGEKDWQ   KYETARRLKK   250
251  CVDKIRNQYR   EDWKSKEMKV   RQRAVALYFI   DKLALRAGNE   KEEGETADTV   300
301  GCCSLRVEHI   NLHPELDGQE   YVVEFDFLGK   DSIRYYNKVP   VEKRVFKNLQ   350
351  LFMENKQPED   DLFDRLNTGI   LNKHLQDLME   GLTAKVFRTY   NASITLQQQL   400
401  KELTAPDENI   PAKILSYNRA   NRAVAILCNH   QIAPPKTFEK   SMMNLQTKID   450
451  AKKEQLADAR   RDLKSAKADA   KVMKDAKTKK   VVESKKKAVQ   RLEEQLMKLE   500
501  VQATDREENK   QIALGTSKLN   FLDPRITVAW   CKKWGVPIEK   IYNKTQREKF   550
551  AWAIDMADED   YEF                                            600
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
214_GLY SER VAR_052592 rs6029542 Polymorphism -
326_LYS ARG VAR_036555 - Unclassified Breast cancer
370_MET THR VAR_010666 - Unclassified CPT-resistant leukemia
533_ASP GLY VAR_007530 rs267607131 Unclassified CPT-resistant leukemia
722_ASN SER VAR_010667 - Unclassified CPT-resistant leukemia
729_THR ALA VAR_007531 - Unclassified CPT-resistant lung cancer