PDB ID 1EZF     CHAIN A
Protein name FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE
Uniprot Accession P37268
The number of similar proteins 77
The number of binding states 4
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1EZF (CHAIN: A)
1 Monomeric state
2 P37268   P37268  
3 P37268   P37268   P37268  
4 P37268   P37268   P37268   P37268  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MDRNSLSNSL   KTCYKYLNQT   SRSFAAVIQA   LDGEMRNAVC   IFYLVLRALD   50
51   TLEDDMTISV   EKKVPLLHNF   HSFLYQPDWR   FMESKEKDRQ   VLEDFPTISL   100
101   EFRNLAEKYQ   TVIADICRRM   GIGMAEFLDK   HVTSEQEWDK   YCHYVAGLVG   150
151   IGLSRLFSAS   EFEDPLVGED   TERANSMGLF   LQKTNIIRDY   LEDQQGGREF   200
201   WPQEVWSRYV   KKLGDFAKPE   NIDLAVQCLN   ELITNALHHI   PDVITYLSRL   250
251   RNQSVFNFCA   IPQVMAIATL   AACYNNQQVF   KGAVKIRKGQ   AVTLMMDATN   300
301   MPAVKAIIYQ   YMEEIYHRIP   DSDPSSSKTR   QIISTIRTQN     350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
45_LYS ARG VAR_011786 rs4731
LB/B - -
45_LYS ARG gnomAD
chr8:11666337 		rs4731
- 0.0668131 -
45_LYS GLU 8.3kJPN
chr8:11666336 		rs764164796
- 0.0004 -
45_LYS ARG 8.3kJPN
chr8:11666337 		rs4731
- 0.0091 -
49_GLN HIS 8.3kJPN
chr8:11666350 		-
- 0.0001 -
51_SER CYS 8.3kJPN
chr8:11666354 		-
- 0.0001 -
63_GLY GLU 8.3kJPN
chr8:11666391 		rs542597307
- 0.0001 -
66_ARG GLY 8.3kJPN
chr8:11666399 		-
- 0.0001 -
77_ARG TER 8.3kJPN
chr8:11667207 		rs778046889
- 0.0001 -
87_THR SER gnomAD
chr8:11667238 		rs200217031
- 0.000421508 -
87_THR SER 8.3kJPN
chr8:11667238 		rs200217031
- 0.0001 -
89_SER THR 8.3kJPN
chr8:11667244 		rs374031686
- 0.0001 -
98_HIS ARG 8.3kJPN
chr8:11667271 		-
- 0.0001 -
99_ASN SER 8.3kJPN
chr8:11667274 		rs367935206
- 0.0001 -
102_SER CYS gnomAD
chr8:11667283 		rs149103491
- 0.000501054 -
112_MET THR 8.3kJPN
chr8:11667313 		-
- 0.0001 -
128_ILE PHE 8.3kJPN
chr8:11679259 		-
- 0.0001 -
136_ALA THR 8.3kJPN
chr8:11679283 		-
- 0.0001 -
148_ARG TRP 8.3kJPN
chr8:11679319 		rs138781417
- 0.0001 -
148_ARG GLN 8.3kJPN
chr8:11679320 		rs201022112
- 0.0001 -
152_ILE VAL 8.3kJPN
chr8:11679331 		rs752630539
- 0.0001 -
171_TYR TER 8.3kJPN
chr8:11683535 		rs754529217
- 0.0001 -
174_TYR CYS gnomAD
chr8:11683543 		rs139230476
- 0.000248163 -
174_TYR CYS 8.3kJPN
chr8:11683543 		rs139230476
- 0.0001 -
181_ILE VAL 8.3kJPN
chr8:11683563 		rs749461746
- 0.0001 -
185_ARG SER 8.3kJPN
chr8:11683575 		rs376669118
- 0.0001 -
192_PHE TYR 8.3kJPN
chr8:11683597 		-
- 0.0001 -
197_VAL GLY 8.3kJPN
chr8:11683612 		-
- 0.0001 -
203_ARG HIS gnomAD
chr8:11683630 		rs140001524
- 0.000298891 -
211_LEU VAL 8.3kJPN
chr8:11683653 		rs904011
- - -
225_GLN GLU 8.3kJPN
chr8:11683695 		-
- 0.0001 -
252_ILE VAL 8.3kJPN
chr8:11687804 		-
- 0.0001 -
261_GLU ASP 8.3kJPN
chr8:11687833 		-
- 0.0009 -
263_ILE THR gnomAD
chr8:11687838 		rs777100951
- 0.000361993 -
278_SER LEU 8.3kJPN
chr8:11687883 		rs371623501
- 0.0001 -
289_CYS TYR 8.3kJPN
chr8:11687916 		-
- 0.0001 -
290_ALA GLY 8.3kJPN
chr8:11687919 		rs1291406206
- 0.0001 -
300_LEU TER ClinVar
chr8:11689046 		rs1810791017
Likely pathogenic - Squalene synthase deficiency [MONDO:MONDO:0032566,MedGen:C4748427,OMIM:618156]
302_ALA THR 8.3kJPN
chr8:11689051 		-
- 0.0001 -
305_ASN HIS 8.3kJPN
chr8:11689060 		rs750785313
- 0.0001 -
308_GLN ARG gnomAD
chr8:11689070 		rs866126681
- 0.000254625 -
309_VAL MET 8.3kJPN
chr8:11689072 		-
- 0.0001 -
310_PHE LEU gnomAD
chr8:11689077 		rs556178209
- 0.00059672 -
313_ALA PRO 8.3kJPN
chr8:11689084 		rs746780985
- 0.0001 -
340_GLN GLU 8.3kJPN
chr8:11689165 		-
- 0.0001 -
344_GLU ASP 8.3kJPN
chr8:11689179 		-
- 0.0001 -
355_SER CYS 8.3kJPN
chr8:11695928 		rs937395981
- 0.0001 -
356_SER CYS gnomAD
chr8:11695931 		rs79708434
- 0.00189062 -
356_SER CYS 8.3kJPN
chr8:11695931 		rs79708434
- 0.0196 -
357_SER ARG gnomAD
chr8:11695935 		rs748342272
- 0.000181065 -
359_THR ARG 8.3kJPN
chr8:11695940 		rs150943942
- 0.0001 -
368_THR MET gnomAD
chr8:11695967 		rs755672538
- 0.000267909 -
369_GLN ARG gnomAD
chr8:11695970 		rs189378553
- 0.000239198 -
369_GLN ARG 8.3kJPN
chr8:11695970 		rs189378553
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.