PDB ID 1F42     CHAIN A
Protein name INTERLEUKIN-12 BETA CHAIN
Uniprot Accession P29460
The number of similar proteins 17
The number of binding states 10
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1F42 (CHAIN: A)
1 Monomeric state
2 Q9NPF7  
3 P29459  
4 Q9NPF7   3QWR  
5 Q9NPF7   Q9NPF7  
6 P42701   Q5VWK5   Q9NPF7  
7 Q5VWK5   Q9NPF7   5MZV  
8 Q9NPF7   5NJD   5NJD  
9 3HMX   3HMX   P29459  
10 Q9NPF7   4GRW   4GRW   4GRW  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   IWELKKDVYV   VELDWYPDAP   GEMVVLTCDT   PEEDGITWTL   DQSSEVLGSG   50
51   KTLTIQVKEF   GDAGQYTCHK   GGEVLSHSLL   LLHKKEDGIW   STDILKDQKE   100
101   PKNKTFLRCE   AKNYSGRFTC   WWLTTISTDL   TFSVKSSRGS   SDPQGVTCGA   150
151   ATLSAERVRG   DNKEYEYSVE   CQEDSACPAA   EESLPIEVMV   DAVHKLKYEN   200
201   YTSSFFIRDI   IKPDPPKNLQ   LKPLKNSRQV   EVSWEYPDTW   STPHSYFSLT   250
251   FCVQVQGKSK   REKKDRVFTD   KTSATVICRK   NASISVRAQD   RYYSSSWSEW   300
301   ASVPCS           350

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
11_VAL ILE VAR_020001 rs3213096
LB/B - -
11_VAL ILE gnomAD
chr5:158750329
rs3213096
- 0.00633204 -
11_VAL ILE 8.3kJPN
chr5:158750329
rs3213096
- 0.0001 -
42_GLN HIS 8.3kJPN
chr5:158750234
-
- 0.0001 -
48_GLY SER 8.3kJPN
chr5:158750218
rs201684769
- 0.0001 -
56_GLN PRO 8.3kJPN
chr5:158750193
rs1361534479
- 0.0001 -
65_GLN TER ClinVar
chr5:158750167
rs1562113567
Pathogenic - Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency [MONDO:MONDO:0013954,MedGen:C4013948,OMIM:614890,Orphanet:319558]
72_GLY SER 8.3kJPN
chr5:158750146
-
- 0.0001 -
73_GLU LYS gnomAD
chr5:158750143
rs56287471
- 0.000377893 -
78_SER LEU gnomAD
chr5:158750127
rs144694601
- 0.000131274 -
87_ASP TYR 8.3kJPN
chr5:158750101
-
- 0.0001 -
93_ASP ASN 8.3kJPN
chr5:158750083
-
- 0.0002 -
102_LYS ARG 8.3kJPN
chr5:158749513
rs199703726
- 0.0008 -
133_SER ASN 8.3kJPN
chr5:158749420
rs1409483647
- 0.0001 -
147_THR MET gnomAD
chr5:158747505
rs565345523
- 0.000163266 -
147_THR LYS 8.3kJPN
chr5:158747505
-
- 0.0001 -
148_CYS TER ClinVar
chr5:158747501
rs771036480
Pathogenic - Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency [MONDO:MONDO:0013954,MedGen:C4013948,OMIM:614890,Orphanet:319558]
157_ARG THR gnomAD
chr5:158747475
rs375159171
- 0.000127379 -
160_GLY ARG gnomAD
chr5:158747467
rs10045130
- 0.000362261 -
191_ASP ASN 8.3kJPN
chr5:158747374
-
- 0.0001 -
193_VAL ILE 8.3kJPN
chr5:158747368
rs79446920
- 0.0001 -
204_SER ASN gnomAD
chr5:158747334
rs55661460
- 0.00220801 -
204_SER ASN 8.3kJPN
chr5:158747334
rs55661460
- 0.0367 -
222_LYS ARG 8.3kJPN
chr5:158745868
-
- 0.0001 -
228_ARG GLN gnomAD
chr5:158745850
rs74644143
- 0.000461405 -
253_VAL ILE gnomAD
chr5:158745776
rs189324104
- 0.00023465 -
255_VAL PHE 8.3kJPN
chr5:158745770
-
- 0.0001 -
266_ARG THR gnomAD
chr5:158743817
rs370904274
- 0.00110552 -
269_THR MET gnomAD
chr5:158743808
rs367828574
- 0.000149554 -
276_VAL PHE VAR_049170 rs3213119
LB/B - -
276_VAL PHE gnomAD
chr5:158743788
rs3213119
- 0.0207309 -
278_CYS TER ClinVar
chr5:158743780
rs1290071275
Pathogenic - Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency [MONDO:MONDO:0013954,MedGen:C4013948,OMIM:614890,Orphanet:319558]
279_ARG CYS 8.3kJPN
chr5:158743779
rs780789325
- 0.0001 -
291_ARG HIS 8.3kJPN
chr5:158743742
rs377524637
- 0.0001 -
294_SER GLY 8.3kJPN
chr5:158743734
-
- 0.0002 -
303_VAL MET gnomAD
chr5:158743707
rs56064925
- 0.000104486 -
305_CYS TER 8.3kJPN
chr5:158743699
rs138991749
- 0.0004 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.