PDB ID 1F8U     CHAIN A
Protein name ACETYLCHOLINESTERASE
Uniprot Accession P22303
The number of similar proteins 99
The number of binding states 3
The number of binding partners 2

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1F8U (CHAIN: A)
1 P01403  
2 Monomeric state
3 P22303  

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Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   EGREDAELLV   TVRGGRLRGI   RLKTPGGPVS   AFLGIPFAEP   PMGPRRFLPP   50
51   EPKQPWSGVV   DATTFQSVCY   QYVDTLYPGF   EGTEMWNPNR   ELSEDCLYLN   100
101   VWTPYPRPTS   PTPVLVWIYG   GGFYSGASSL   DVYDGRFLVQ   AERTVLVSMN   150
151   YRVGAFGFLA   LPGSREAPGN   VGLLDQRLAL   QWVQENVAAF   GGDPTSVTLF   200
201   GQSAGAASVG   MHLLSPPSRG   LFHRAVLQSG   APNGPWATVG   MGEARRRATQ   250
251   LAHLVGCPPG   GTGGNDTELV   ACLRTRPAQV   LVNHEWHVLP   QESVFRFSFV   300
301   PVVDGDFLSD   TPEALINAGD   FHGLQVLVGV   VKDEGSYFLV   YGAPGFSKDN   350
351   ESLISRAEFL   AGVRVGVPQV   SDLAAEAVVL   HYTDWLHPED   PARLREALSD   400
401   VVGDHNVVCP   VAQLAGRLAA   QGARVYAYVF   EHRASTLSWP   LWMGVPHGYE   450
451   IEFIFGIPLD   PSRNYTAEEK   IFAQRLMRYW   ANFARTGDPN   EPRDPKAPQW   500
501   PPYTAGAQQY   VSLDLRPLEV   RRGLRAQACA   FWNRFLPKLL   SATDTLDEAE   550
551   RQWKAEFHRW   SSYMVHWKNQ   FDHYSKQDRC   SDL     600

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
11_THR MET gnomAD
chr7:100491729
rs116298479
- 0.000181574 -
21_ARG SER gnomAD
chr7:100491700
rs375017123
- 0.0001168 -
25_PRO LEU gnomAD
chr7:100491687
rs114782198
- 0.000111773 -
25_PRO LEU 8.3kJPN
chr7:100491687
rs114782198
- 0.0091 -
26_GLY ARG gnomAD
chr7:100491685
rs17234982
- 0.00198851 -
51_GLU ALA 8.3kJPN
chr7:100491609
rs1246706696
- 0.0001 -
58_GLY GLU gnomAD
chr7:100491588
rs114367422
- 0.00193456 -
67_SER ASN 8.3kJPN
chr7:100491561
rs760043016
- 0.0001 -
104_PRO ALA VAR_021326 rs17885778
LB/B - -
104_PRO ALA gnomAD
chr7:100491451
rs17885778
- 0.00102671 -
107_ARG LEU gnomAD
chr7:100491441
rs141299237
- 0.000447721 -
107_ARG LEU 8.3kJPN
chr7:100491441
rs141299237
- 0.0004 -
116_VAL ILE 8.3kJPN
chr7:100491415
rs146564868
- 0.0001 -
162_PRO LEU 8.3kJPN
chr7:100491276
rs755147655
- 0.0001 -
216_PRO LEU gnomAD
chr7:100491114
rs143875983
- 0.0010634 -
226_VAL MET 8.3kJPN
chr7:100491085
rs745889870
- 0.0001 -
266_ASP VAL 8.3kJPN
chr7:100490964
rs202174292
- 0.0001 -
291_GLN TER 8.3kJPN
chr7:100490890
-
- 0.0001 -
302_VAL GLU VAR_011934 rs8286
LB/B - -
318_ALA VAL gnomAD
chr7:100490808
rs750142131
- 0.000255793 -
318_ALA THR 8.3kJPN
chr7:100490809
rs116131706
- 0.0001 -
322_HIS ASN VAR_002359 rs1799805
LB/B - -
322_HIS ASN gnomAD
chr7:100490797
rs1799805
- 0.0398096 -
326_VAL ALA 8.3kJPN
chr7:100490438
-
- 0.0001 -
355_SER ASN 8.3kJPN
chr7:100490351
rs775874742
- 0.0007 -
429_VAL ILE gnomAD
chr7:100490130
rs546907479
- 0.00012481 -
475_ARG GLN 8.3kJPN
chr7:100489991
rs774422002
- 0.0009 -
504_THR MET 8.3kJPN
chr7:100488909
rs1430893148
- 0.0001 -
509_GLN HIS 8.3kJPN
chr7:100488893
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.