PDB ID 1FIB CHAIN A
Protein name GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT
Uniprot Accession P02679
The number of similar proteins 47
The number of binding states 6
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
Downdload
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partners
  4
  3
  2
  1
  0
Sequence information
1   VQIHDITGKD   CQDIANKGAK   QSGLYFIKPL   KANQQFLVYC   EIDGSGNGWT   50
51   VFQKRLDGSV   DFKKNWIQYK   EGFGHLSPTG   TTEFWLGNEK   IHLISTQSAI   100
101   PYALRVELED   WNGRTSTADY   AMFKVGPEAD   KYRLTYAYFA   GGDAGDAFDG   150
151   FDFGDDPSDK   FFTSHNGMQF   STWDNDNDKF   EGNCAEQDGS   GWWMNKCHAG   200
201   HLNGVYYQGG   TYSKASTPNG   YDNGIIWATW   KTRWYSMKKT   TMKIIPFNRL   250
251   TIGEGQQHHL   GGAKQAGDV         300
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
165_GLY ARG ClinVar
chr4:155530877
rs6063 Pathogenic Fibrinogen Milano XII, digenic [MedGen:C4016097]
275_ARG CYS VAR_002409 rs121913087 Polymorphism -
275_ARG HIS VAR_002410 rs121913088 Disease Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]
277_THR PRO VAR_072726 - Disease Congenital afibrinogenemia (CAFBN) [MIM:202400]
292_GLY VAL VAR_002411 rs121913089 Disease Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]
301_ASP HIS VAR_072727 - Disease Congenital afibrinogenemia (CAFBN) [MIM:202400]
308_ASN LYS VAR_002412 - Unclassified -
308_ASN ILE VAR_002413 rs121913090 Polymorphism -
309_GLY ASP VAR_015853 - Unclassified -
310_MET THR VAR_002414 rs121913091 Polymorphism -
315_TRP TER ClinVar
chr4:155527964
rs1553965519 Pathogenic Afibrinogenemia, congenital [MedGen:C2584774,OMIM:202400,Orphanet:ORPHA98880]
319_ASN ASP VAR_072728 - Disease Congenital afibrinogenemia (CAFBN) [MIM:202400]
329_GLN ARG VAR_002416 rs121913092 Polymorphism -
330_ASP TYR VAR_002417 rs121913093 Polymorphism -
330_ASP VAL VAR_002418 rs121913094 Disease Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]
337_ASN LYS VAR_002419 - Unclassified -
358_SER CYS VAR_002421 - Unclassified -
375_ARG GLY VAR_002422 rs75848804 Polymorphism -
375_ARG TRP VAR_072729 rs75848804 Disease Congenital afibrinogenemia (CAFBN) [MIM:202400]
378_SER PRO ClinVar
chr4:155526138
rs587777720 Pathogenic Hypodysfibrinogenemia [MedGen:C0472803,SNOMED CT:234458004]
384_MET VAL VAR_014171 rs6061 Polymorphism -