PDB ID 1FW1     CHAIN A
Protein name GLUTATHIONE TRANSFERASE ZETA
Uniprot Accession O43708
The number of similar proteins 3
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1FW1 (CHAIN: A)
1 Monomeric state
2 O43708  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MQAGKPILYS   YFRSSCSWRV   RIALALKGID   YKTVPINLIK   DGGQQFSKDF   50
51   QALNPMKQVP   TLKIDGITIH   QSLAIIEYLE   ETRPTPRLLP   QDPKKRASVR   100
101   MISDLIAGGI   QPLQNLSVLK   QVGEEMQLTW   AQNAITCGFN   ALEQILQSTA   150
151   GIYCVGDEVT   MADLCLVPQV   ANAERFKVDL   TPYPTISSIN   KRLLVLEAFQ   200
201   VSHPCRQPDT   PTELRA         250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
30_ASP ASN 8.3kJPN
chr14:77793201 		rs774350894
- 0.0001 -
32_LYS GLU VAR_009705 rs7975
LB/B - -
32_GLU LYS gnomAD
chr14:77793207 		rs7975
- 0.306578 -
32_GLU LYS 8.3kJPN
chr14:77793207 		rs7975
- 0.52 -
42_GLY ARG gnomAD
chr14:77793237 		rs7972
- 0.0700038 -
47_SER CYS gnomAD
chr14:77793819 		rs138526285
- 0.000142424 -
52_ALA THR 8.3kJPN
chr14:77793833 		-
- 0.0001 -
82_MET THR gnomAD
chr14:77794283 		rs1046428
- 0.812679 -
82_MET THR 8.3kJPN
chr14:77794283 		rs1046428
- 0.9729 -
91_GLN ARG 8.3kJPN
chr14:77794310 		rs964930791
- 0.0001 -
99_VAL MET VAR_079260 -
LP/P - Maleylacetoacetate isomerase deficiency (MAAID) [MIM:617596]
99_VAL MET ClinVar
chr14:77794333 		rs140540096
Likely pathogenic - Maleylacetoacetate isomerase deficiency|not provided [MONDO:MONDO:0060527,MedGen:C1291607,OMIM:617596|MedGen:C3661900]
99_VAL MET gnomAD
chr14:77794333 		rs140540096
- 0.000501704 -
100_ARG HIS 8.3kJPN
chr14:77794337 		rs369022018
- 0.0004 -
132_GLN ARG gnomAD
chr14:77795518 		rs149349623
- 0.000290362 -
133_ASN HIS VAR_014505 rs2234955
LB/B - -
133_ASN HIS gnomAD
chr14:77795520 		rs2234955
- 0.000819353 -
133_ASN HIS 8.3kJPN
chr14:77795520 		rs2234955
- 0.0001 -
134_ALA THR gnomAD
chr14:77795523 		rs149972480
- 0.000358001 -
150_ALA VAL VAR_079261 -
LP/P - Maleylacetoacetate isomerase deficiency (MAAID) [MIM:617596]
150_ALA VAL 8.3kJPN
chr14:77796125 		rs199552988
- 0.001 -
159_VAL MET 8.3kJPN
chr14:77796653 		-
- 0.0001 -
176_PHE LEU 8.3kJPN
chr14:77797415 		rs762764115
- 0.0001 -
189_ILE VAL gnomAD
chr14:77797452 		rs143936720
- 0.000350034 -
195_VAL ALA gnomAD
chr14:77797471 		rs112779751
- 0.000314258 -
203_HIS GLN 8.3kJPN
chr14:77797496 		rs373514679
- 0.0004 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.