PDB ID 1GS0     CHAIN A
Protein name POLY (ADP-RIBOSE) POLYMERASE-2
Uniprot Accession O88554
The number of similar proteins 4
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1GS0 (CHAIN: A)
1 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   ESQLDLRVQE   LLKLICNVQT   MEEMMIEMKY   DTKRAPLGKL   TVAQIKAGYQ   50
51   SLKKIEDCIR   AGQHGRALVE   ACNEFYTRIP   HDFGLSIPPV   IRTEKELSDK   100
101   VKLLEALGDI   EIALKLVKSE   RQGLEHPLDQ   HYRNLHCALR   PLDHESNEFK   150
151   VISQYLQSTH   APTHKDYTMT   LLDVFEVEKE   GEKEAFREDL   PNRMLLWHGS   200
201   RLSNWVGILS   HGLRVAPPEA   PITGYMFGKG   IYFADMSSKS   ANYCFASRLK   250
251   NTGLLLLSEV   ALGQCNELLE   ANPKAQGLLR   GKHSTKGMGK   MAPSPAHFIT   300
301   LNGSTVPLGP   ASDTGILNPE   GYTLNYNEFI   VYSPNQVRMR   YLLKIQFNFL   350
351   Q           400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
211_ASP GLY gnomAD
chr14:20822308 		rs3093921
- 0.0193043 -
213_ARG TRP 8.3kJPN
chr14:20822313 		rs1215869595
- 0.0001 -
213_ARG GLN 8.3kJPN
chr14:20822314 		rs1362556952
- 0.0002 -
224_VAL ASP 8.3kJPN
chr14:20822347 		-
- 0.0001 -
226_ALA VAL 8.3kJPN
chr14:20822353 		rs201349330
- 0.0001 -
261_ILE VAL 8.3kJPN
chr14:20823018 		rs3093925
- 0.0007 -
261_ILE THR 8.3kJPN
chr14:20823019 		rs371236543
- 0.0001 -
266_ARG TRP gnomAD
chr14:20823033 		rs140156644
- 0.000236477 -
266_ARG TRP 8.3kJPN
chr14:20823033 		rs140156644
- 0.0229 -
272_ARG GLN gnomAD
chr14:20823052 		rs3093926
- 0.0425736 -
272_ARG TER 8.3kJPN
chr14:20823051 		rs751074729
- 0.0001 -
292_ARG HIS gnomAD
chr14:20823916 		rs369495700
- 0.000136294 -
292_ARG CYS 8.3kJPN
chr14:20823915 		rs747138138
- 0.0004 -
298_ARG GLN gnomAD
chr14:20823934 		rs61755964
- 0.000292585 -
300_GLN ARG 8.3kJPN
chr14:20823940 		rs771871656
- 0.0001 -
307_ILE THR 8.3kJPN
chr14:20823961 		rs2275010
- 0.0012 -
346_ARG CYS gnomAD
chr14:20824158 		rs199837737
- 0.000124259 -
356_LYS THR 8.3kJPN
chr14:20824189 		rs757840139
- 0.0001 -
372_ASP ASN 8.3kJPN
chr14:20824511 		rs369416638
- 0.0001 -
388_GLU LYS gnomAD
chr14:20824559 		rs200082490
- 0.000372632 -
395_ASP GLU 8.3kJPN
chr14:20824582 		-
- 0.0001 -
412_VAL ALA 8.3kJPN
chr14:20824787 		-
- 0.0001 -
420_ARG TER 8.3kJPN
chr14:20824810 		rs553724644
- 0.0001 -
457_ASN HIS 8.3kJPN
chr14:20825282 		rs74485011
- 0.0405 -
479_PRO LEU gnomAD
chr14:20825595 		rs558330340
- 0.000184884 -
503_HIS ARG 8.3kJPN
chr14:20825667 		rs776376567
- 0.0001 -
546_ARG TRP 8.3kJPN
chr14:20825912 		rs761738969
- 0.0001 -
546_ARG GLN 8.3kJPN
chr14:20825913 		rs774497167
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.