PDB ID 1H2T     CHAIN C
Protein name 80 KDA NUCLEAR CAP BINDING PROTEIN
Uniprot Accession Q09161
The number of similar proteins 11
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1H2T (CHAIN: C)
1 P52298  
2 P52298   P52292  
3 P52298   Q9BXP5  
4 P52298   Q86YN6  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   KTSDANETED   HLESLICKVG   EKSACSLESN   LEGLAGVLEA   DLPNYKSKIL   50
51   RLLCTVARLL   PEKLTIYTTL   VGLLNARNYN   FGGEFVEAMI   RQLKESLKAN   100
101   NYNEAVYLVR   FLSDLVNCHV   IAAPSMVAMF   ENFVSVTQEE   DVPQVRRDWY   150
151   VYAFLSSLPW   VGKELYEKKD   AEMDRIFANT   ESYLKRRQKT   HVPMLQVWTA   200
201   DKPHPQEEYL   DCLWAQIQKL   KKDRWQERHI   LRPYLAFDSI   LCEALQHNLP   250
251   PFTPPPHTED   SVYPMPRVIF   RMFDYTDDPE   GPVMPGSHSV   ERFVIEENLH   300
301   CIIKSHWKER   KTCAAQLVSY   PGKNKIPLNY   HIVEVIFAEL   FQLPAPPHID   350
351   VMYTTLLIEL   CKLQPGSLPQ   VLAQATEMLY   MRLDTMNTTC   VDRFINWFSH   400
401   HLSNFQFRWS   WEDWSDCLSQ   DPESPKPKFV   REVLEKCMRL   SYHQRILDIV   450
451   PPTFSALCPS   NPTCIYKYGD   ESSNSLPGHS   VALCLAVAFK   SKATNDEIFS   500
501   ILKDVPNPNQ   DDDDDEGFSF   NPLKIEVFVQ   TLLHLAAKSF   SHSFSALAKF   550
551   HEVFKTLAES   DEGKLHVLRV   MFEVWRNHPQ   MIAVLVDKMI   RTQIVDCAAV   600
601   ANWIFSSELS   RDFTRLFVWE   ILHSTIRKMN   KHVGAQSEQK   NLFLVIFQRF   650
651   IMILTEHLVR   CETDGTSVLT   PWYKNCIERL   QQIFLQHHQI   IQQYMVTLEN   700
701   LLFTAELDPH   ILAVFQQFCA   LQA       750

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
64_TYR HIS 8.3kJPN
chr9:100403910 		-
- 0.0001 -
125_VAL MET gnomAD
chr9:100405634 		rs143745791
- 0.00163754 -
156_THR SER 8.3kJPN
chr9:100407483 		-
- 0.0001 -
159_GLU ASP gnomAD
chr9:100407494 		rs367832805
- 0.000123333 -
213_MET THR 8.3kJPN
chr9:100409800 		-
- 0.0001 -
219_ALA SER gnomAD
chr9:100409817 		rs146305083
- 0.00117074 -
275_PRO THR 8.3kJPN
chr9:100410431 		-
- 0.0001 -
347_LEU VAL 8.3kJPN
chr9:100413635 		-
- 0.0001 -
401_ARG CYS 8.3kJPN
chr9:100417192 		-
- 0.0001 -
407_THR ALA 8.3kJPN
chr9:100417210 		-
- 0.0001 -
410_VAL GLY 8.3kJPN
chr9:100417220 		-
- 0.0001 -
414_ILE VAL gnomAD
chr9:100417988 		rs562093927
- 0.000132203 -
446_PRO LEU gnomAD
chr9:100418331 		rs77602722
- 0.013361 -
450_ARG LYS 8.3kJPN
chr9:100418343 		-
- 0.0002 -
454_GLU ASP 8.3kJPN
chr9:100418356 		-
- 0.0001 -
596_ASN LYS 8.3kJPN
chr9:100425320 		rs200307901
- 0.0011 -
630_ARG CYS gnomAD
chr9:100426712 		rs199656608
- 0.000195334 -
646_ARG CYS 8.3kJPN
chr9:100429079 		-
- 0.0001 -
727_ARG GLY gnomAD
chr9:100431908 		rs201932796
- 0.000131322 -
776_PRO THR gnomAD
chr9:100433434 		rs142212526
- 0.000270535 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.