PDB ID 1HTI     CHAIN A
Protein name TRIOSEPHOSPHATE ISOMERASE
Uniprot Accession P60174
The number of similar proteins 51
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1HTI (CHAIN: A)
1 P60174  
2 Monomeric state

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Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   APSRKFFVGG   NWKMNGRKQS   LGELIGTLNA   AKVPADTEVV   CAPPTAYIDF   50
51   ARQKLDPKIA   VAAQNCYKVT   NGAFTGEISP   GMIKDCGATW   VVLGHSERRH   100
101   VFGESDELIG   QKVAHALAEG   LGVIACIGEK   LDEREAGITE   KVVFEQTKVI   150
151   ADNVKDWSKV   VLAYEPVWAI   GTGKTATPQQ   AQEVHEKLRG   WLKSNVSDAV   200
201   AQSTRIIYGG   SVTGATCKEL   ASQPDVDGFL   VGGASLKPEF   VDIINAKQ   250

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
1_ALA VAL 8.3kJPN
chr12:6976735
rs781891860
- 0.0001 -
26_GLY SER 8.3kJPN
chr12:6976809
-
- 0.0001 -
33_VAL ALA 8.3kJPN
chr12:6976831
-
- 0.0001 -
41_CYS TYR VAR_007534 rs121964848
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
41_CYS TYR ClinVar
chr12:6978037
rs121964848
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
55_LEU VAL 8.3kJPN
chr12:6978078
-
- 0.0001 -
62_ALA GLY 8.3kJPN
chr12:6978100
-
- 0.0001 -
72_GLY ALA VAR_007535 -
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
104_GLU ASP VAR_007536 rs121964845
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
104_GLU ASP ClinVar
chr12:6978338
rs121964845
Pathogenic/Likely pathogenic - Triosephosphate isomerase deficiency|not provided [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868|MedGen:C3661900]
113_VAL ALA 8.3kJPN
chr12:6978438
-
- 0.0001 -
118_ALA VAL 8.3kJPN
chr12:6978453
-
- 0.0004 -
122_GLY ARG VAR_007537 rs121964846
LB/B - -
145_GLU TER ClinVar
chr12:6978533
rs121964850
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
149_VAL PHE gnomAD
chr12:6978545
rs150585849
- 0.000552882 -
154_VAL MET VAR_007538 rs188138723
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
154_VAL MET gnomAD
chr12:6978857
rs188138723
- 0.0012088 -
163_ALA GLY 8.3kJPN
chr12:6978885
-
- 0.0001 -
170_ILE VAL VAR_007539 rs121964849
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
170_ILE VAL ClinVar
chr12:6978905
rs121964849
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
196_VAL ILE 8.3kJPN
chr12:6979258
rs782801396
- 0.0001 -
231_VAL MET VAR_007540 rs1555132614
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
240_PHE LEU VAR_007541 rs121964847
LP/P - Triosephosphate isomerase deficiency (TPID) [MIM:615512]
240_PHE LEU ClinVar
chr12:6979518
rs121964847
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
240_PHE SER ClinVar
chr12:6979519
rs587777440
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.