PDB ID 1IAR     CHAIN B
Protein name PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN)
Uniprot Accession P24394
The number of similar proteins 7
The number of binding states 6
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1IAR (CHAIN: B)
1 P05112  
2 6WGL   6WGL  
3 P78552   P35225  
4 P05112   P78552  
5 P05112   P31785  
6 P05112   6OEL   6OEL   P31785  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   FKVLQEPTCV   SDYMSISTCE   WKMNGPTNCS   TELRLLYQLV   FLLSEAHTCI   50
51   PENNGGAGCV   CHLLMDDVVS   ADNYTLDLWA   GQQLLWKGSF   KPSEHVKPRA   100
101   PGNLTVHTNV   SDTLLLTWSN   PYPPDNYLYN   HLTYAVNIWS   ENDPADFRIY   150
151   NVTYLEPSLR   IAASTLKSGI   SYRARVRAWA   QAYNTTWSEW   SPSTKWHNSY   200
201   REPFEQH           250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
10_VAL ILE 8.3kJPN
chr16:27353474 		rs372988882
- 0.0001 -
18_THR ALA 8.3kJPN
chr16:27353498 		rs749110570
- 0.0005 -
28_ASN SER gnomAD
chr16:27353529 		rs201852059
- 0.000163047 -
28_ASN ILE 8.3kJPN
chr16:27353529 		rs201852059
- - -
34_ARG CYS 8.3kJPN
chr16:27353546 		rs191774649
- 0.0013 -
40_VAL PHE gnomAD
chr16:27353564 		rs555743307
- 0.000286353 -
44_SER PHE 8.3kJPN
chr16:27353577 		-
- 0.0001 -
50_ILE VAL VAR_008034 rs1805010
LB/B - -
50_ILE PHE VAR_059302 rs1805010
LB/B - -
50_ILE LEU VAR_059303 rs1805010
LB/B - -
50_ILE VAL gnomAD
chr16:27356203 		rs1805010
- 0.447775 -
50_ILE VAL 8.3kJPN
chr16:27356203 		rs1805010
- 0.6196 -
57_ALA THR gnomAD
chr16:27356224 		rs144651842
- 0.0127006 -
57_ALA THR 8.3kJPN
chr16:27356224 		rs144651842
- 0.0652 -
60_VAL MET gnomAD
chr16:27356233 		rs141983833
- 0.000202953 -
89_SER PHE gnomAD
chr16:27356321 		rs543167942
- 0.000171399 -
90_PHE ILE gnomAD
chr16:27356323 		rs199703000
- 0.000685652 -
91_LYS ASN 8.3kJPN
chr16:27356328 		-
- 0.0001 -
94_GLU LYS gnomAD
chr16:27356335 		rs141903283
- 0.000299578 -
95_HIS ARG 8.3kJPN
chr16:27356339 		-
- 0.0001 -
133_THR SER 8.3kJPN
chr16:27357898 		-
- 0.0001 -
143_ASP ASN 8.3kJPN
chr16:27357928 		rs568385218
- 0.001 -
143_ASP GLU 8.3kJPN
chr16:27357930 		rs775265328
- 0.0001 -
144_PRO LEU gnomAD
chr16:27357932 		rs145473866
- 0.000107464 -
160_ARG HIS gnomAD
chr16:27363901 		rs150955128
- 0.0149458 -
160_ARG HIS 8.3kJPN
chr16:27363901 		rs150955128
- 0.0035 -
175_ARG TRP 8.3kJPN
chr16:27363945 		rs370524692
- 0.0001 -
175_ARG GLN 8.3kJPN
chr16:27363946 		rs147547377
- 0.0047 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.