PDB ID 1IVR     CHAIN A
Protein name ASPARTATE AMINOTRANSFERASE
Uniprot Accession P00508
The number of similar proteins 23
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1IVR (CHAIN: A)
1 Monomeric state
2 P00508  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   SSWWSHVEMG   PPDPILGVTE   AFKRDTNSKK   MNLGVGAYRD   DNGKPYVLNC   50
51   VRKAEAMIAA   KKMDKEYLPI   AGLADFTRAS   AELALGENSE   AFKSGRYVTV   100
101   QGISGTGSLR   VGANFLQRFF   KFSRDVYLPK   PSWGNHTPIF   RDAGLQLQAY   150
151   RYYDPKTCSL   DFTGAMEDIS   KIPEKSIILL   HACAHNPTGV   DPRQEQWKEL   200
201   ASVVKKRNLL   AYFDMAYQGF   ASGDINRDAW   ALRHFIEQGI   DVVLSQSYAK   250
251   NMGLYGERAG   AFTVICRDAE   EAKRVESQLK   ILIRPMYSNP   PMNGARIASL   300
301   ILNTPELRKE   WLVEVKGMAD   RIISMRTQLV   SNLKKEGSSH   NWQHITDQIG   350
351   MFCFTGLKPE   QVERLTKEFS   IYMTKDGRIS   VAGVASSNVG   YLAHAIHQVT   400
401   K           450

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
5_THR SER 8.3kJPN
chr16:58757795 		-
- 0.0001 -
21_ALA GLY 8.3kJPN
chr16:58757747 		rs771477611
- 0.0002 -
24_ARG TRP gnomAD
chr16:58757739 		rs147242485
- 0.000155184 -
36_GLY CYS 8.3kJPN
chr16:58757703 		-
- 0.0001 -
39_ARG TRP gnomAD
chr16:58757694 		rs557150117
- 0.000115344 -
47_VAL ILE gnomAD
chr16:58757670 		rs144716246
- 0.000278485 -
47_VAL ILE 8.3kJPN
chr16:58757670 		rs144716246
- 0.0002 -
49_PRO LEU gnomAD
chr16:58757663 		rs765537389
- 0.000103464 -
60_ALA SER gnomAD
chr16:58756164 		rs137905758
- 0.0001193 -
60_ALA THR 8.3kJPN
chr16:58756164 		-
- 0.0001 -
62_ASN LYS 8.3kJPN
chr16:58756156 		-
- 0.0001 -
90_GLU LYS 8.3kJPN
chr16:58756074 		rs756305221
- 0.0001 -
94_SER ARG 8.3kJPN
chr16:58756060 		-
- 0.0001 -
125_ASP ASN gnomAD
chr16:58752568 		rs78784246
- 0.00401107 -
148_GLN LEU 8.3kJPN
chr16:58752498 		-
- 0.0002 -
151_ARG GLN 8.3kJPN
chr16:58752489 		rs773502230
- 0.0004 -
151_ARG TRP 8.3kJPN
chr16:58752490 		rs373294477
- 0.0001 -
155_PRO LEU 8.3kJPN
chr16:58752477 		rs772294547
- 0.0002 -
159_GLY SER gnomAD
chr16:58752466 		rs11076256
- 0.061211 -
159_GLY SER 8.3kJPN
chr16:58752466 		rs11076256
- 0.0029 -
163_THR ARG 8.3kJPN
chr16:58752453 		-
- 0.0001 -
165_ALA THR gnomAD
chr16:58752448 		rs201083152
- 0.000103914 -
165_ALA THR 8.3kJPN
chr16:58752448 		rs201083152
- 0.0003 -
168_ASP ASN gnomAD
chr16:58752439 		rs149988435
- 0.000826358 -
172_ILE THR 8.3kJPN
chr16:58752200 		-
- 0.0001 -
193_ARG HIS gnomAD
chr16:58752137 		rs139235307
- 0.0131535 -
211_ALA VAL 8.3kJPN
chr16:58750701 		rs754471368
- 0.0001 -
217_TYR HIS 8.3kJPN
chr16:58750684 		-
- 0.0001 -
233_ARG GLY ClinVar
chr16:58750636 		rs752927520
Likely pathogenic - Early infantile epileptic encephalopathy with suppression bursts|Developmental and epileptic encephalopathy, 82 [MONDO:MONDO:0100062,MedGen:C0393706,OMIM:PS308350,Orphanet:1934|MONDO:MONDO:0032880,MedGen:C5231473,OMIM:618721]
237_GLU GLN 8.3kJPN
chr16:58750624 		rs368352559
- 0.0001 -
239_GLY ASP 8.3kJPN
chr16:58750617 		rs777180671
- 0.0002 -
296_ARG TRP 8.3kJPN
chr16:58749964 		rs1406591910
- 0.0001 -
308_ARG GLY ClinVar
chr16:58749928 		rs1247507359
Likely pathogenic - Early infantile epileptic encephalopathy with suppression bursts|Developmental and epileptic encephalopathy, 82 [MONDO:MONDO:0100062,MedGen:C0393706,OMIM:PS308350,Orphanet:1934|MONDO:MONDO:0032880,MedGen:C5231473,OMIM:618721]
317_VAL GLY gnomAD
chr16:58743454 		rs30842
- 0.711896 -
317_VAL GLY 8.3kJPN
chr16:58743454 		rs30842
- 0.617 -
321_ARG CYS 8.3kJPN
chr16:58743443 		rs1465507115
- 0.0001 -
326_ARG GLN 8.3kJPN
chr16:58743427 		rs752127201
- 0.0001 -
328_GLN GLU gnomAD
chr16:58743422 		rs112943773
- 0.000115346 -
334_LYS ARG 8.3kJPN
chr16:58743403 		-
- 0.0001 -
335_LYS GLU gnomAD
chr16:58743401 		rs150122367
- 0.000767499 -
335_LYS GLU 8.3kJPN
chr16:58743401 		rs150122367
- 0.007 -
337_GLY VAL ClinVar
chr16:58743394 		rs1597696047
Likely pathogenic - Early infantile epileptic encephalopathy with suppression bursts|Developmental and epileptic encephalopathy, 82 [MONDO:MONDO:0100062,MedGen:C0393706,OMIM:PS308350,Orphanet:1934|MONDO:MONDO:0032880,MedGen:C5231473,OMIM:618721]
364_ARG GLN gnomAD
chr16:58742190 		rs151225545
- 0.000207495 -
364_ARG TRP gnomAD
chr16:58742191 		rs141302038
- 0.000291615 -
376_ASP GLY 8.3kJPN
chr16:58742154 		-
- 0.0001 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.