PDB ID 1JD0     CHAIN A
Protein name CARBONIC ANHYDRASE XII
Uniprot Accession O43570
The number of similar proteins 62
The number of binding states 5
The number of binding partners 3

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1JD0 (CHAIN: A)
1 O43570  
2 Monomeric state
3 O43570   O43570  
4 6RPS   6RPS  
5 O43570   O43570   O43570  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   ASKWTYFGPD   GENSWSKKYP   SCGGLLQSPI   DLHSDILQYD   ASLTPLEFQG   50
51   YNLSANKQFL   LTNNGHSVKL   NLPSDMHIQG   LQSRYSATQL   HLHWGNPNDP   100
101   HGSEHTVSGQ   HFAAELHIVH   YNSDLYPDAS   TASNKSEGLA   VLAVLIEMGS   150
151   FNPSYDKIFS   HLQHVKYKGQ   EAFVPGFNIE   ELLPERTAEY   YRYRGSLTTP   200
201   PCNPTVLWTV   FRNPVQISQE   QLLALETALY   CTHMDDPSPR   EMINNFRQVQ   250
251   KFDERLVYTS   FSQ         300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
16_TRP TER 8.3kJPN
chr15:63638886 		-
- 0.0001 -
34_HIS ARG 8.3kJPN
chr15:63638833 		-
- 0.0001 -
45_THR MET gnomAD
chr15:63638800 		rs144831502
- 0.000139169 -
96_HIS GLN VAR_081182 rs775067652
LP/P - Hyperchlorhidrosis, isolated (HYCHL) [MIM:143860]
96_HIS GLN ClinVar
chr15:63637742 		rs775067652
Pathogenic - Isolated hyperchlorhidrosis [MONDO:MONDO:0007747,MedGen:C1840437,OMIM:143860,Orphanet:542657]
102A_PRO SER 8.3kJPN
chr15:63637723 		-
- 0.0001 -
104_GLY SER 8.3kJPN
chr15:63637717 		rs752351418
- 0.0001 -
117_GLU LYS VAR_065292 rs267606694
LP/P - Hyperchlorhidrosis, isolated (HYCHL) [MIM:143860]
117_GLU LYS ClinVar
chr15:63637678 		rs267606694
Pathogenic - Isolated hyperchlorhidrosis [MONDO:MONDO:0007747,MedGen:C1840437,OMIM:143860,Orphanet:542657]
125_SER PRO 8.3kJPN
chr15:63634275 		-
- 0.0001 -
142_ALA THR 8.3kJPN
chr15:63634224 		rs369979536
- 0.0001 -
148_ILE THR 8.3kJPN
chr15:63634205 		rs772871937
- 0.0001 -
167_VAL ILE gnomAD
chr15:63632931 		rs145237465
- 0.000226651 -
177_PRO LEU 8.3kJPN
chr15:63632626 		rs149993127
- 0.0001 -
186_PRO LEU 8.3kJPN
chr15:63632599 		rs61733915
- 0.0001 -
193_ARG SER 8.3kJPN
chr15:63632576 		-
- 0.0001 -
195_ARG GLN gnomAD
chr15:63632569 		rs151338276
- 0.00326101 -
195_ARG GLN 8.3kJPN
chr15:63632569 		rs151338276
- 0.0001 -
207_VAL ALA gnomAD
chr15:63632533 		rs757714646
- 0.00010339 -
225_ALA ASP 8.3kJPN
chr15:63631137 		-
- 0.0001 -
235_MET ARG 8.3kJPN
chr15:63631107 		-
- 0.0001 -
237_ASP TYR 8.3kJPN
chr15:63631102 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.