PDB ID 1JY1     CHAIN A
Protein name TYROSYL-DNA PHOSPHODIESTERASE
Uniprot Accession Q9NUW8
The number of similar proteins 43
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1JY1 (CHAIN: A)
1 Monomeric state
2 Q9NUW8  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   LEDPGEGQDI   WDXLDKGNPF   QFYLTRVSGV   KPKYNSGALH   IKDILSPLFG   50
51   TLVSSAQFNY   CFDVDWLVKQ   YPPEFRKKPI   LLVHGDKREA   KAHLHAQAKP   100
101   YENISLCQAK   LDIAFGTHHT   KXXLLLYEEG   LRVVIHTSNL   IHADWHQKTQ   150
151   GIWLSPLYPR   IADGTHKSGE   SPTHFKANLI   SYLTAYNAPS   LKEWIDVIHK   200
201   HDLSETNVYL   IGSTPGRFQG   SQKDNWGHFR   LKKLLKDHAS   SXPNAESWPV   250
251   VGQFSSVGSL   GADESKWLCS   EFKESXLTLG   KESKTPGKSS   VPLYLIYPSV   300
301   ENVRTSLEGY   PAGGSLPYSI   QTAEKQNWLH   SYFHKWSAET   SGRSNAXPHI   350
351   KTYXRPSPDF   SKIAWFLVTS   ANLSKAAWGA   LEKNGTQLXI   RSYELGVLFL   400
401   PSALGLDSFK   VKQKFFAGSQ   EPXATFPVPY   DLPPELYGSK   DRPWIWNIPY   450
451   VKAPDTHGNX   WVPS         500

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
187_ASP GLY VAR_025820 rs35271143
LB/B - -
190_SER PHE 8.3kJPN
chr14:90432500
-
- 0.0001 -
208_VAL MET 8.3kJPN
chr14:90433729
rs776360792
- 0.0004 -
216_PRO SER 8.3kJPN
chr14:90433753
-
- 0.0002 -
219_PHE LEU gnomAD
chr14:90433762
rs148474327
- 0.00016304 -
245_TYR TER 8.3kJPN
chr14:90437594
rs778913360
- - -
262_HIS GLN 8.3kJPN
chr14:90442154
-
- 0.0002 -
263_HIS GLN 8.3kJPN
chr14:90442157
rs562317662
- 0.0001 -
276_ARG TRP 8.3kJPN
chr14:90446918
rs757694490
- 0.0001 -
280_HIS ARG 8.3kJPN
chr14:90446931
rs749517155
- 0.0002 -
289_TRP CYS 8.3kJPN
chr14:90446959
-
- 0.0001 -
304_ARG GLN VAR_025821 rs34452707
LB/B - -
304_ARG TER ClinVar
chr14:90450885
rs370121773
Likely pathogenic - Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 [MONDO:MONDO:0011801,MedGen:C4759870,OMIM:607250,Orphanet:94124]
304_ARG GLN gnomAD
chr14:90450886
rs34452707
- 0.00156015 -
304_ARG TER 8.3kJPN
chr14:90450885
rs370121773
- 0.0001 -
311_LYS GLU gnomAD
chr14:90450906
rs753807686
- 0.000167166 -
346_ASP HIS 8.3kJPN
chr14:90451011
rs199879149
- 0.0001 -
361_ARG HIS 8.3kJPN
chr14:90451505
rs371563681
- 0.0001 -
389_ALA THR gnomAD
chr14:90455282
rs138044459
- 0.000410009 -
401_VAL PHE 8.3kJPN
chr14:90455318
rs892739281
- 0.0001 -
418_GLU LYS 8.3kJPN
chr14:90455369
rs759300952
- 0.0001 -
435_VAL ILE 8.3kJPN
chr14:90455420
-
- 0.0001 -
448_ARG GLN gnomAD
chr14:90456086
rs144746398
- 0.000286761 -
487_ARG HIS 8.3kJPN
chr14:90459746
rs567684858
- 0.0001 -
493_HIS ARG VAR_017144 rs119467003
LP/P - Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 (SCAN1) [MIM:607250]
493_HIS ARG ClinVar
chr14:90459764
rs119467003
Pathogenic - Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1|not provided [MONDO:MONDO:0011801,MedGen:C4759870,OMIM:607250,Orphanet:94124|MedGen:CN517202]
506_LYS ARG 8.3kJPN
chr14:90459803
-
- 0.0002 -
569_THR ALA VAR_025822 rs35973343
LB/B - -
569_THR ALA gnomAD
chr14:90499510
rs35973343
- 0.00111409 -
578_PRO GLN 8.3kJPN
chr14:90499538
-
- 0.0001 -
581_TYR SER 8.3kJPN
chr14:90499547
-
- 0.0001 -
583_SER GLY gnomAD
chr14:90499552
rs201355368
- 0.000350645 -
600_THR MET 8.3kJPN
chr14:90509459
rs772139596
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.