PDB ID 1K4S     CHAIN A
Protein name DNA topoisomerase I
Uniprot Accession P11387
The number of similar proteins 15
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1K4S (CHAIN: A)
1 Monomeric state

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Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   KKPKNKDKDK   KVPEPDNKKK   KPKKEEEQKW   KWWEEERYPE   GIKWKFLEHK   50
51   GPVFAPPYEP   LPENVKFYYD   GKVMKLSPKA   EEVATFFAKM   LDHEYTTKEI   100
101   FRKNFFKDWR   KEMTNEEKNI   ITNLSKCDFT   QMSQYFKAQT   EARKQMSKEE   150
151   KLKIKEENEK   LLKEYGFCIM   DNHKERIANF   KIEPPGLFRG   RGNHPKMGML   200
201   KRRIMPEDII   INCSKDAKVP   SPPPGHKWKE   VRHDNKVTWL   VSWTENIQGS   250
251   IKYIMLNPSS   RIKGEKDWQK   YETARRLKKC   VDKIRNQYRE   DWKSKEMKVR   300
301   QRAVALYFID   KLALRAGNEK   EEGETADTVG   CCSLRVEHIN   LHPELDGQEY   350
351   VVEFDFLGKD   SIRYYNKVPV   EKRVFKNLQL   FMENKQPEDD   LFDRLNTGIL   400
401   NKHLQDLMEG   LTAKVFRTYN   ASITLQQQLK   ELTAPDENIP   AKILSYNRAN   450
451   RAVAILCNHQ   RAPPKTFEKS   MMNLQTKIDA   KKEQLADARR   DLKSAKADAK   500
501   VMKDAKTKKV   VESKKKAVQR   LEEQLMKLEV   QATDREENKQ   IALGTSKLNX   550
551   LDPRITVAWC   KKWGVPIEKI   YNKTQREKFA   WAIDMADEDY   EF   600

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
214_GLY SER VAR_052592 rs6029542
LB/B - -
291_LYS THR 8.3kJPN
chr20:39726874
-
- 0.0001 -
296_ASN SER gnomAD
chr20:39726889
rs144769453
- 0.000210873 -
304_GLN HIS 8.3kJPN
chr20:39726914
-
- 0.0001 -
326_LYS ARG VAR_036555 -
US - Breast cancer
335_LEU VAL 8.3kJPN
chr20:39728723
-
- 0.0001 -
370_MET THR VAR_010666 -
US - CPT-resistant leukemia
376_ARG GLN 8.3kJPN
chr20:39728847
-
- 0.0001 -
380_GLU LYS 8.3kJPN
chr20:39728858
rs756669367
- 0.0001 -
418_GLU LYS ClinVar
chr20:39729937
rs121434562
Pathogenic - DNA topoisomerase I, camptothecin-resistant [MedGen:C4016020]
452_LYS GLN 8.3kJPN
chr20:39741467
rs1265323416
- 0.0001 -
462_ARG GLY 8.3kJPN
chr20:39741497
rs777034891
- 0.0001 -
469_GLU LYS 8.3kJPN
chr20:39741518
-
- 0.0001 -
471_LYS ARG 8.3kJPN
chr20:39741525
rs765735179
- 0.0006 -
533_ASP GLY VAR_007530 rs267607131
US - CPT-resistant leukemia
546_ARG GLN 8.3kJPN
chr20:39742794
-
- 0.0001 -
596_ILE VAL 8.3kJPN
chr20:39744996
-
- 0.0001 -
722_ASN SER VAR_010667 -
US - CPT-resistant leukemia
729_THR ALA VAR_007531 -
US - CPT-resistant lung cancer
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.