PDB ID 1L9M     CHAIN A
Protein name Protein-glutamine glutamyltransferase E3
Uniprot Accession Q08188
The number of similar proteins 10
The number of binding states 3
The number of binding partners 2

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1L9M (CHAIN: A)
1 Q08188  
2 Monomeric state
3 8OXW   8OXW  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   AALGVQSINW   QTAFNRQAHH   TDKFSSQELI   LRRGQNFQVL   MIMNKGLGSN   50
51   ERLEFIVSTG   PYPSESAMTK   AVFPLSNGSS   GGWSAVLQAS   NGNTLTISIS   100
101   SPASAPIGRY   TMALQIFSQG   GISSVKLGTF   ILLFNPWLNV   DSVFMGNHAE   150
151   REEYVQEDAG   IIFVGSTNRI   GMIGWNFGQF   EEDILSICLS   ILDRSLNFRR   200
201   DAATDVASRN   DPKYVGRVLS   AMINSNDDNG   VLAGNWSGTY   TGGRDPRSWD   250
251   GSVEILKNWK   KSGLSPVRYG   QCWVFAGTLN   TALRSLGIPS   RVITNFNSAH   300
301   DTDRNLSVDV   YYDPMGNPLD   KGSDSVWNFH   VWNEGWFVRS   DLGPSYGGWQ   350
351   VLDATPQERS   QGVFQCGPAS   VIGVREGDVQ   LNFDMPFIFA   EVNADRITWL   400
401   YDNTTGKQWK   NSVNSHTIGR   YISTKAVGSN   ARMDVTDKYK   YPEGSDQERQ   450
451   VFQKALGKLK   PNTPFAATSS   MGLETEEQEP   SIIGKLKVAG   MLAVGKEVNL   500
501   VLLLKNLSRD   TKTVTVNMTA   WTIIYNGTLV   HEVWKDSATM   SLDPEEEAEH   550
551   PIKISYAQYE   RYLKSDNMIR   ITAVCKVPDE   SEVVVERDII   LDNPTLTLEV   600
601   LNEARVRKPV   NVQMLFSNPL   DEPVRDCVLM   VEGSGLLLGN   LKIDVPTLGP   650
651   KERSRVRFDI   LPSRSGTKQL   LADFSCNKFP   AIKAMLSIDV   AE   700

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
1_ALA VAL 8.3kJPN
chr20:2276714 		-
- 0.0001 -
12_THR LYS VAR_040067 rs214803
LB/B - -
12_THR LYS gnomAD
chr20:2290333 		rs214803
- 0.81927 -
12_THR LYS 8.3kJPN
chr20:2290333 		rs214803
- 0.9584 -
13_ALA GLY gnomAD
chr20:2290336 		rs749279971
- 0.000286385 -
25_SER PRO 8.3kJPN
chr20:2290371 		-
- 0.0002 -
32_ARG TRP 8.3kJPN
chr20:2290392 		rs1335768228
- 0.0001 -
38_GLN HIS 8.3kJPN
chr20:2290412 		-
- 0.0002 -
77_ASN SER gnomAD
chr20:2290875 		rs151028271
- 0.000143334 -
85_ALA VAL 8.3kJPN
chr20:2290899 		rs774924175
- 0.0001 -
92_GLY ASP gnomAD
chr20:2290920 		rs544584169
- 0.000298567 -
105_ALA THR 8.3kJPN
chr20:2290958 		rs146616453
- 0.0001 -
109_ARG TRP gnomAD
chr20:2290970 		rs139117716
- 0.000123322 -
109_ARG TRP 8.3kJPN
chr20:2290970 		rs139117716
- 0.0001 -
109_ARG GLN 8.3kJPN
chr20:2290971 		rs779784575
- 0.0001 -
112_MET VAL 8.3kJPN
chr20:2290979 		rs768258292
- 0.0001 -
112_MET ILE 8.3kJPN
chr20:2290981 		-
- 0.0001 -
121_GLY SER gnomAD
chr20:2291006 		rs551977439
- 0.00048541 -
162_ILE LEU VAR_040068 rs6048066
LB/B - -
162_ILE LEU gnomAD
chr20:2291722 		rs6048066
- 0.027171 -
187_ILE VAL 8.3kJPN
chr20:2293565 		rs749575246
- 0.0008 -
204_THR SER 8.3kJPN
chr20:2293617 		-
- 0.0001 -
215_VAL ILE 8.3kJPN
chr20:2293649 		rs113905463
- 0.0001 -
225_SER ASN gnomAD
chr20:2297721 		rs146227949
- 0.000569104 -
242_GLY SER 8.3kJPN
chr20:2297771 		rs143810711
- 0.0002 -
244_ARG TRP 8.3kJPN
chr20:2297777 		rs202051623
- 0.0003 -
247_ARG SER 8.3kJPN
chr20:2297788 		-
- 0.0001 -
248_SER ASN VAR_040069 rs214814
LB/B - -
248_SER ASN gnomAD
chr20:2297790 		rs214814
- 0.10867 -
248_SER CYS 8.3kJPN
chr20:2297789 		-
- 0.0001 -
248_SER ASN 8.3kJPN
chr20:2297790 		rs214814
- 0.0734 -
251_GLY SER 8.3kJPN
chr20:2297798 		rs372347727
- 0.0001 -
268_ARG LEU 8.3kJPN
chr20:2297850 		rs150052126
- 0.0001 -
315_MET THR 8.3kJPN
chr20:2298095 		rs754582243
- 0.0004 -
319_LEU PRO 8.3kJPN
chr20:2298107 		rs539342653
- 0.0001 -
326_VAL ILE gnomAD
chr20:2298127 		rs370121854
- 0.000218954 -
347_GLY SER gnomAD
chr20:2306553 		rs139599978
- 0.000308537 -
356_PRO LEU gnomAD
chr20:2306581 		rs200497601
- 0.000204431 -
383_PHE LEU 8.3kJPN
chr20:2308830 		rs575267128
- 0.0039 -
384_ASP ASN 8.3kJPN
chr20:2308831 		rs189594278
- 0.0041 -
390_ALA THR 8.3kJPN
chr20:2308849 		rs141575267
- 0.0001 -
395_ASP ASN 8.3kJPN
chr20:2308864 		rs375593105
- 0.0001 -
396_ARG HIS 8.3kJPN
chr20:2308868 		rs146171554
- 0.0001 -
402_ASP ASN 8.3kJPN
chr20:2308885 		rs778672902
- 0.0002 -
405_THR ALA gnomAD
chr20:2308894 		rs539884508
- 0.000425485 -
406_GLY VAL 8.3kJPN
chr20:2308898 		-
- 0.0001 -
416_HIS ASP gnomAD
chr20:2308927 		rs150302326
- 0.000338034 -
432_ARG CYS gnomAD
chr20:2308975 		rs780553362
- 0.000159148 -
432_ARG CYS 8.3kJPN
chr20:2308975 		rs780553362
- 0.0001 -
432_ARG LEU 8.3kJPN
chr20:2308976 		rs551559240
- 0.0001 -
438_LYS ASN 8.3kJPN
chr20:2308995 		-
- 0.0001 -
443_GLU GLN 8.3kJPN
chr20:2309008 		-
- 0.0001 -
450_GLN TER ClinVar
chr20:2312665 		rs779702016
Pathogenic - Uncombable hair syndrome 2 [MONDO:MONDO:0014989,MedGen:C4310649,OMIM:617251]
451_VAL GLY 8.3kJPN
chr20:2312669 		-
- 0.0001 -
486_LEU MET 8.3kJPN
chr20:2312773 		-
- 0.0001 -
491_MET LEU gnomAD
chr20:2312788 		rs201410609
- 0.000175042 -
528_THR MET gnomAD
chr20:2312900 		rs563551325
- 0.000203601 -
541_SER THR 8.3kJPN
chr20:2312938 		rs200893750
- 0.0006 -
557_ALA THR gnomAD
chr20:2315791 		rs199889633
- 0.000119342 -
557_ALA THR 8.3kJPN
chr20:2315791 		rs199889633
- 0.0008 -
569_ILE PHE 8.3kJPN
chr20:2315827 		-
- 0.0002 -
570_ARG GLN 8.3kJPN
chr20:2315831 		rs531290820
- 0.0007 -
575_CYS TYR 8.3kJPN
chr20:2315846 		rs761258830
- 0.0002 -
578_PRO LEU 8.3kJPN
chr20:2315855 		rs761142782
- 0.0001 -
580_GLU ASP gnomAD
chr20:2315862 		rs145272149
- 0.000103402 -
582_GLU ASP gnomAD
chr20:2315868 		rs137862904
- 0.00014717 -
587_ARG TRP gnomAD
chr20:2315881 		rs187614014
- 0.00010744 -
592_ASP HIS 8.3kJPN
chr20:2315896 		-
- 0.0002 -
603_GLU LYS gnomAD
chr20:2320509 		rs199983032
- 0.000103638 -
635_GLY SER 8.3kJPN
chr20:2320605 		rs367606978
- 0.0001 -
646_PRO ARG gnomAD
chr20:2321085 		rs200294064
- 0.000224514 -
649_GLY GLU gnomAD
chr20:2321094 		rs114998364
- 0.00212916 -
653_GLY ARG gnomAD
chr20:2321105 		rs214830
- 0.708568 -
653_GLY TRP 8.3kJPN
chr20:2321105 		rs214830
- - -
655_ARG TRP gnomAD
chr20:2321111 		rs151074346
- 0.000523113 -
657_ARG HIS gnomAD
chr20:2321118 		rs190943274
- 0.000107732 -
657_ARG CYS 8.3kJPN
chr20:2321117 		rs760403495
- 0.0001 -
664_ARG TRP gnomAD
chr20:2321138 		rs150949349
- 0.0030721 -
664_ARG GLN gnomAD
chr20:2321139 		rs149720612
- 0.00145828 -
664_ARG GLN 8.3kJPN
chr20:2321139 		rs149720612
- 0.0001 -
665_SER CYS 8.3kJPN
chr20:2321141 		-
- 0.0001 -
668_LYS GLU 8.3kJPN
chr20:2321150 		rs781210245
- 0.0002 -
672_ALA THR gnomAD
chr20:2321162 		rs535186868
- 0.000318558 -
672_ALA VAL gnomAD
chr20:2321163 		rs146717993
- 0.00106708 -
673_ASP GLU gnomAD
chr20:2321167 		rs186345115
- 0.000111477 -
673_ASP ASN 8.3kJPN
chr20:2321165 		rs140423684
- 0.0001 -
673_ASP GLU 8.3kJPN
chr20:2321167 		rs186345115
- 0.0001 -
679_PHE LEU gnomAD
chr20:2321183 		rs145595091
- 0.00163197 -
686_LEU MET VAR_055360 rs45581032
LB/B - -
686_LEU MET gnomAD
chr20:2321204 		rs45581032
- 0.00010349 -
686_LEU MET 8.3kJPN
chr20:2321204 		rs45581032
- 0.0001 -
688_ILE VAL 8.3kJPN
chr20:2321210 		rs1568636134
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.