PDB ID 1LQB CHAINC
Protein nameVON HIPPEL-LINDAU DISEASE TUMOR SUPRESSOR
Uniprot Accession P40337
The number of similar proteins 6
The number of binding states 3
The number of binding partners 3
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1LQB (CHAIN: C)
1 Q15369 Q16665 Q15370
2 Q15369
3 Q15369 Q15370
Downdload
Format:
Molecule viewer
#binding
partners
  2
  1
  0
Sequence information
1  GSMEAGRPRP   VLRSVNSREP   SQVIFCNRSP   RVVLPVWLNF   DGEPQPYPTL   50
51  PPGTGRRIHS   YRGHLWLFRD   AGTHDGLLVN   QTELFVPSLN   VDGQPIFANI   100
101  TLPVYTLKER   CLQVVRSLVK   PENYRRLDIV   RSLYEDLEDH   PNVQKDLERL   150
151  TQERIAHQRM   GD                                             200
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
63_LEU PRO VAR_034987 rs104893827 Disease Pheochromocytoma (PCC) [MIM:171300]
64_ARG PRO VAR_034988 rs104893826 Disease Pheochromocytoma (PCC) [MIM:171300]
65_SER ALA VAR_034989 rs869025616 Disease Pheochromocytoma (PCC) [MIM:171300]
68_SER TRP VAR_005675 - Disease Pheochromocytoma (PCC) [MIM:171300]
70_GLU LYS VAR_005676 rs5030802 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
74_VAL GLY VAR_005677 rs5030803 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
76_PHE SER VAR_005681 rs730882033 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
78_ASN THR VAR_005684 rs5030804 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
79_ARG PRO VAR_005685 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
80_SER ASN VAR_005688 rs5030805 Disease Pheochromocytoma (PCC) [MIM:171300]
81_PRO SER VAR_005689 rs104893829 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
82_ARG PRO VAR_005690 rs794726890 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
84_VAL LEU VAR_005692 rs5030827 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
86_PRO HIS VAR_008097 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
88_TRP SER VAR_005698 rs119103277 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
89_LEU PRO VAR_005700 rs5030807 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
91_PHE LEU VAR_005701 - Unclassified -
93_GLY SER VAR_005705 rs5030808 Disease Pheochromocytoma (PCC) [MIM:171300]
96_GLN PRO VAR_005706 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
98_TYR HIS VAR_005707 rs5030809 Disease Pheochromocytoma (PCC) [MIM:171300]
101_LEU ARG VAR_005709 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
104_GLY ALA VAR_005710 - Unclassified -
105_THR PRO VAR_005711 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
106_GLY ASP VAR_005712 - Unclassified Lung cancer
107_ARG GLY VAR_034991 rs397516440 Disease Pheochromocytoma (PCC) [MIM:171300]
110_HIS TYR VAR_055087 rs17855706 Polymorphism -
111_SER ARG VAR_005716 rs765978945 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
112_TYR ASN VAR_034992 rs104893824 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
114_GLY SER VAR_005720 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
115_HIS ARG VAR_008098 rs5030812 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
116_LEU VAL VAR_005724 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
117_TRP CYS VAR_005725 rs727504215 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
118_LEU ARG VAR_005727 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
119_PHE SER VAR_005729 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
121_ASP GLY VAR_005730 rs5030832 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
122_ALA ILE VAR_034993 - Disease Pheochromocytoma (PCC) [MIM:171300]
126_ASP TYR VAR_034994 rs104893831 Disease Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]
128_LEU PHE VAR_005731 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
130_VAL LEU VAR_005733 rs104893830 Disease Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]
131_ASN THR VAR_005735 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
135_LEU PHE VAR_034995 rs119103278 Polymorphism -
136_PHE TYR VAR_008099 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
143_ASP GLU VAR_005738 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
145_GLN HIS VAR_008100 rs771727849 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
147_ILE THR VAR_034996 - Disease Pheochromocytoma (PCC) [MIM:171300]
149_ALA THR VAR_005740 rs587780077 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
154_PRO LEU VAR_005741 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
155_VAL MET VAR_008101 rs869025659 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
156_TYR ASN VAR_034997 - Disease Pheochromocytoma (PCC) [MIM:171300]
157_THR ILE VAR_005746 rs869025660 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
158_LEU VAL VAR_005749 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
159_LYS GLU VAR_005750 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
161_ARG GLY VAR_005753 rs5030818 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
162_CYS TYR VAR_005757 rs397516444 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
163_LEU PRO VAR_034998 rs28940297 Disease Renal cell carcinoma (RCC) [MIM:144700]
164_GLN HIS VAR_008102 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
166_VAL ASP VAR_008103 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
167_ARG TRP VAR_005762 rs5030820 Disease Pheochromocytoma (PCC) [MIM:171300]
170_VAL GLY VAR_005765 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
175_TYR ASP VAR_005766 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
176_ARG TRP VAR_008104 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
178_LEU GLN VAR_005769 rs5030822 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
180_ILE VAL VAR_005770 rs377715747 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
184_LEU PRO VAR_005772 - Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
186_GLU LYS VAR_005773 rs367545984 Disease Von Hippel-Lindau disease (VHLD) [MIM:193300]
188_LEU VAL VAR_005777 rs5030824 Disease Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]
191_HIS ASP VAR_034999 rs28940301 Disease Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]
192_PRO SER VAR_035000 rs28940300 Disease Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]
198_LEU GLN VAR_035001 - Disease Pheochromocytoma (PCC) [MIM:171300]
200_ARG TRP VAR_005779 rs28940298 Disease Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]