PDB ID 1LS3     CHAIN A
Protein name Serine Hydroxymethyltransferase
Uniprot Accession p07511
The number of similar proteins 20
The number of binding states 3
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1LS3 (CHAIN: A)
1 p07511   p07511  
2 Monomeric state
3 P07511  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   ATAVNGAPRD   AALWSSHEQM   LAQPLKDSDA   EVYDIIKKES   NRQRVGLELI   50
51   ASENFASRAV   LEALGSCLNN   KYSEGYPGQR   YYGGTEHIDE   LETLCQKRAL   100
101   QAYGLDPQCW   GVNVQPYSGS   PANFAVYTAL   VEPHGRIMGL   DLPDGGHLTH   150
151   GFMTDKKKIS   ATSIFFESMA   YKVNPDTGYI   DYDRLEENAR   LFHPKLIIAG   200
201   TSCYSRNLDY   GRLRKIADEN   GAYLMADMAH   ISGLVVAGVV   PSPFEHCHVV   250
251   TTTTHKTLRG   CRAGMIFYRR   GVRSVDPKTG   KEILYNLESL   INSAVFPGLQ   300
301   GGPHNHAIAG   VAVALKQAMT   PEFKEYQRQV   VANCRALSAA   LVELGYKIVT   350
351   GGSDNHLILV   DLRSKGTDGG   RAEKVLEACS   IACNKNTCPG   DKSALRPSGL   400
401   RLGTPALTSR   GLLEKDFQKV   AHFIHRGIEL   TVQIQDDTGP   RATLKEFKEK   450
451   LAGDEKHQRA   VRALRQEVES   FAALFPLPGL   PGF     500

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
-10_ASP GLU 8.3kJPN
chr17:18259257
-
- 0.0001 -
24_ASN ASP 8.3kJPN
chr17:18257104
rs201557147
- 0.0009 -
25_ARG GLN 8.3kJPN
chr17:18257100
rs770150583
- 0.0001 -
82_ALA THR 8.3kJPN
chr17:18251699
-
- 0.0001 -
94_GLN ARG 8.3kJPN
chr17:18251650
rs759784953
- 0.0002 -
115_ARG HIS 8.3kJPN
chr17:18250919
rs766011995
- 0.0001 -
123_ASP HIS 8.3kJPN
chr17:18250896
rs768492092
- 0.0003 -
125_GLY ASP gnomAD
chr17:18250889
rs563467894
- 0.00029054 -
134_ASP GLU gnomAD
chr17:18250861
rs558723951
- 0.000151173 -
163_ARG CYS gnomAD
chr17:18244076
rs148701087
- 0.00064225 -
169_LEU PRO gnomAD
chr17:18244057
rs73291881
- 0.000100793 -
176_CYS SER 8.3kJPN
chr17:18243561
-
- 0.0001 -
179_ARG TER 8.3kJPN
chr17:18243552
rs748683840
- 0.0001 -
185_ARG TRP gnomAD
chr17:18243534
rs115185998
- 0.000330246 -
188_LYS ARG gnomAD
chr17:18243524
rs78909145
- 0.00607471 -
188_LYS ARG 8.3kJPN
chr17:18243524
rs78909145
- 0.0001 -
198_MET LEU 8.3kJPN
chr17:18243495
-
- 0.003 -
212_VAL MET gnomAD
chr17:18243453
rs150889470
- 0.000111406 -
221_HIS ARG 8.3kJPN
chr17:18243425
-
- 0.0001 -
268_ALA VAL 8.3kJPN
chr17:18238881
rs1262762031
- 0.0001 -
300_GLU GLN gnomAD
chr17:18236516
rs7215148
- 0.000701564 -
309_ILE THR 8.3kJPN
chr17:18236488
rs758066653
- 0.0001 -
324_ARG HIS gnomAD
chr17:18233949
rs141263245
- 0.000151121 -
324_ARG CYS 8.3kJPN
chr17:18233950
rs758472877
- 0.001 -
355_SER ASN gnomAD
chr17:18232693
rs139056136
- 0.000111838 -
374B_GLU GLY 8.3kJPN
chr17:18232630
-
- 0.0001 -
404A_ASP TYR gnomAD
chr17:18232153
rs546838005
- 0.00022071 -
404A_ASP TYR 8.3kJPN
chr17:18232153
rs546838005
- - -
409_VAL MET 8.3kJPN
chr17:18232135
rs769762115
- 0.0001 -
412_ARG TRP 8.3kJPN
chr17:18232123
rs551074461
- 0.0001 -
418A_LEU PHE gnomAD
chr17:18232096
rs1979277
- 0.268191 -
418A_LEU PHE 8.3kJPN
chr17:18232096
rs1979277
- 0.0883 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.