PDB ID 1LT7     CHAIN A
Protein name BETAINE-HOMOCYSTEINE METHYLTRANSFERASE
Uniprot Accession Q93088
The number of similar proteins 12
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1LT7 (CHAIN: A)
1 Q93088  
2 Q93088   Q93088   Q93088  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MAPVGGKKAK   KGILERLNAG   EIVIGDGGFV   FALEKRGYVK   AGPWTPEAAV   50
51   EHPEAVRQLH   REFLRAGSNV   MQTFTFYASE   DKLENRGNYV   LEKISGQEVN   100
101   EAAADIARQV   ADEGDALVAG   GVSQTPSYLS   AKSETEVKKV   FLQQLEVFMK   150
151   KNVDFLIAEY   FEHVEEAVWA   VETLIASGKP   VAATMAIGPE   GDLHGVPPGE   200
201   AAVRLVKAGA   SIIGVNCHFD   PTISLKTVKL   MKEGLEAAQL   KAHLMSQPLA   250
251   YHTPDANKQG   FIDLPEFPFG   LEPRVATRWD   IQKYAREAYN   LGVRYIGGCC   300
301   GFEPYHIRAI   AEELAPERGF   LPPASEKHGS   WGSGLDMHTK   PWVRARARKE   350
351   YWENLRIASG   RPYNPSMSKP   DGWGVTKGTA   ELMQQKEATT   EQQLKELFEK   400
401   QKFKSQ           450

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
16_ARG CYS gnomAD
chr5:78411602 		rs56709544
- 0.000348471 -
16_ARG CYS 8.3kJPN
chr5:78411602 		rs56709544
- 0.0011 -
19_ALA THR 8.3kJPN
chr5:78411611 		rs772543723
- 0.0005 -
57_ARG LEU gnomAD
chr5:78415085 		rs147391267
- 0.000112558 -
122_VAL MET 8.3kJPN
chr5:78416251 		rs781266642
- 0.0001 -
196_VAL LEU 8.3kJPN
chr5:78417149 		rs755757711
- 0.0001 -
197_PRO SER gnomAD
chr5:78417152 		rs60947960
- 0.00215608 -
199_GLY SER VAR_061345 rs59866108
LB/B - -
199_GLY SER gnomAD
chr5:78417158 		rs59866108
- 0.0047569 -
239_ARG GLN gnomAD
chr5:78421959 		rs3733890
- 0.302334 -
239_ARG TER 8.3kJPN
chr5:78421958 		rs758916006
- 0.0001 -
239_ARG GLN 8.3kJPN
chr5:78421959 		rs3733890
- 0.2138 -
253_THR SER 8.3kJPN
chr5:78422000 		-
- 0.0001 -
256_CYS TYR gnomAD
chr5:78422010 		rs753107730
- 0.000163573 -
256_CYS TYR 8.3kJPN
chr5:78422010 		rs753107730
- 0.0022 -
279_TRP ARG 8.3kJPN
chr5:78423604 		rs1019608054
- 0.0001 -
285_ALA THR 8.3kJPN
chr5:78423622 		rs141170569
- 0.0001 -
319_GLY ASP gnomAD
chr5:78423725 		rs537868595
- 0.000206985 -
322_PRO SER 8.3kJPN
chr5:78423733 		-
- 0.0001 -
344_ARG TER 8.3kJPN
chr5:78423799 		-
- 0.0001 -
348_ARG THR 8.3kJPN
chr5:78426761 		rs777789050
- 0.0024 -
353_GLU ASP 8.3kJPN
chr5:78426777 		rs781510366
- 0.0001 -
361_ARG GLN gnomAD
chr5:78426800 		rs556850126
- 0.00034237 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.