PDB ID 1LTX     CHAIN A
Protein name RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT
Uniprot Accession Q08602
The number of similar proteins 2
The number of binding states 2
The number of binding partners 2

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1LTX (CHAIN: A)
1 P37727   Q08603  
2 Q08603  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MHGRLKVKTS   EEQAEAKRLE   REQKLKLYQS   ATQAVFQKRQ   AGELDESVLE   50
51   LTSQILGANP   DFATLWNCRR   EVLQHLETEK   SPEESAALVK   AELGFLESCL   100
101   RVNPKSYGTW   HHRCWLLSRL   PEPNWARELE   LCARFLEADE   RNFHCWDYRR   150
151   FVAAQAAVAP   AEELAFTDSL   ITRNFSNYSS   WHYRSCLLPQ   LHPQPDSGPQ   200
201   GRLPENVLLK   ELELVQNAFF   TDPNDQSAWF   YHRWLLGRAE   PHDVLCCVHV   250
251   SREEACLSVC   FSRPLTVGSR   MGTLLLMVDE   APLSVEWRTP   DGRNRPSHVW   300
301   LCDLPAASLN   DQLPQHTFRV   IWTGSDSQKE   CVLLKDRPEC   WCRDSATDEQ   350
351   LFRCELSVEK   STVLQSELES   CKELQELEPE   NKWCLLTIIL   LMRALDPLLY   400
401   EKETLQYFST   LKAVDPMRAA   YLDDLRSKFL   LENSVLKMEY   ADVRVLHLAH   450
451   KDLTVLCHLE   QLLLVTHLDL   SHNRLRALPP   ALAALRCLEV   LQASDNALEN   500
501   VDGVANLPRL   QELLLCNNRL   QQSAAIQPLV   SCPRLVLLNL   QGNSLCQEEG   550
551   IQERLAEMLP   SVSSILT         600

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
30_SER ALA 8.3kJPN
chr14:24740069 		-
- 0.0001 -
39_ARG CYS 8.3kJPN
chr14:24739664 		rs767225082
- 0.001 -
48_VAL MET 8.3kJPN
chr14:24739637 		rs760688629
- 0.0002 -
109_THR SER 8.3kJPN
chr14:24739260 		-
- 0.0001 -
109_THR ALA 8.3kJPN
chr14:24739261 		-
- 0.0001 -
111_HIS TYR 8.3kJPN
chr14:24739255 		-
- 0.0001 -
124_ASN SER gnomAD
chr14:24739215 		rs143463989
- 0.000302163 -
129_LEU VAL gnomAD
chr14:24739201 		rs117588776
- 0.000225646 -
133_ALA SER 8.3kJPN
chr14:24739189 		-
- 0.0001 -
148_TYR PHE gnomAD
chr14:24738885 		rs200602142
- 0.000112621 -
148_TYR CYS 8.3kJPN
chr14:24738885 		rs200602142
- 0.0001 -
149_ARG GLN 8.3kJPN
chr14:24738882 		rs368437109
- 0.0001 -
158_VAL MET gnomAD
chr14:24738856 		rs199629422
- 0.000850669 -
168_ASP ASN gnomAD
chr14:24738826 		rs201930555
- 0.000136456 -
225_ASP ASN 8.3kJPN
chr14:24738328 		-
- 0.0001 -
226_GLN HIS 8.3kJPN
chr14:24738323 		-
- 0.0001 -
233_ARG HIS 8.3kJPN
chr14:24738303 		rs1447882020
- 0.0001 -
244_ALA GLY 8.3kJPN
chr14:24738184 		-
- 0.0001 -
246_ARG HIS 8.3kJPN
chr14:24738178 		rs375241144
- 0.0001 -
246_ARG CYS 8.3kJPN
chr14:24738179 		rs367971962
- 0.0001 -
249_HIS PRO 8.3kJPN
chr14:24738169 		-
- 0.0001 -
252_ARG GLN 8.3kJPN
chr14:24738160 		rs567466887
- 0.0001 -
254_GLU LYS 8.3kJPN
chr14:24738155 		rs536913680
- 0.0002 -
263_ARG GLN gnomAD
chr14:24738127 		rs201499080
- 0.000116023 -
264_PRO LEU 8.3kJPN
chr14:24738124 		rs755647894
- 0.0005 -
268_GLY CYS gnomAD
chr14:24738029 		rs759734789
- 0.000114284 -
270_ARG THR 8.3kJPN
chr14:24738022 		rs774754408
- 0.0004 -
280_ASP ASN 8.3kJPN
chr14:24737993 		-
- 0.0002 -
301_LEU PRO 8.3kJPN
chr14:24737824 		-
- 0.0001 -
314_PRO ALA gnomAD
chr14:24737786 		rs183337992
- 0.00129988 -
319_ARG HIS 8.3kJPN
chr14:24737770 		rs764686950
- 0.0001 -
322_TRP GLY 8.3kJPN
chr14:24737762 		-
- 0.0001 -
340_GLY SER gnomAD
chr14:24737615 		rs74877655
- 0.00359623 -
343_ARG GLN gnomAD
chr14:24737605 		rs201502775
- 0.000136462 -
343_ARG TRP 8.3kJPN
chr14:24737606 		rs369486237
- 0.0001 -
347_THR ARG 8.3kJPN
chr14:24737593 		-
- 0.0001 -
349_GLU LYS 8.3kJPN
chr14:24737588 		rs753161065
- 0.0001 -
392_MET ILE 8.3kJPN
chr14:24737136 		-
- 0.0001 -
409_GLN TER 8.3kJPN
chr14:24737087 		-
- 0.0001 -
420_THR ALA gnomAD
chr14:24736961 		rs729421
- 0.465009 -
420_THR MET 8.3kJPN
chr14:24736960 		rs753923421
- 0.0001 -
420_THR ALA 8.3kJPN
chr14:24736961 		rs729421
- 0.6175 -
426_ARG HIS gnomAD
chr14:24736942 		rs367842090
- 0.000120453 -
426_ARG CYS gnomAD
chr14:24736943 		rs372767329
- 0.000120449 -
430_LEU PHE gnomAD
chr14:24736929 		rs138412943
- 0.00010038 -
435_VAL MET 8.3kJPN
chr14:24736916 		rs370570899
- 0.0001 -
438_MET VAL 8.3kJPN
chr14:24736907 		-
- 0.0001 -
442_GLU LYS 8.3kJPN
chr14:24736895 		rs751373180
- 0.0001 -
461_GLN ARG 8.3kJPN
chr14:24736067 		rs1375960804
- 0.0001 -
505_THR ILE 8.3kJPN
chr14:24735677 		-
- 0.0001 -
565_VAL ILE 8.3kJPN
chr14:24734832 		rs926024865
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.