PDB ID 1MKD     CHAIN A
Protein name Phosphodiesterase 4D
Uniprot Accession Q08499
The number of similar proteins 161
The number of binding states 5
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1MKD (CHAIN: A)
1 Q08499   Q08499   Q08499  
2 Monomeric state
3 Q08499  
4 Q08499   Q08499  
5 Q08499   Q08499   Q08499   Q08499  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   TEQEDVLAKE   LEDVNKWGLH   VFRIAELSGN   RPLTVIMHTI   FQERDLLKTF   50
51   KIPVDTLITY   LMTLEDHYHA   DVAYHNNIHA   ADVVQSTHVL   LSTPALEAVF   100
101   TDLEILAAIF   ASAIHDVDHP   GVSNQFLINT   NSELALMYND   SSVLENHHLA   150
151   VGFKLLQEEN   CDIFQNLTKK   QRQSLRKMVI   DIVLATDMSK   HMNLLADLKT   200
201   MVETKKVTSS   GVLLLDNYSD   RIQVLQNMVH   CADLSNPTKP   LQLYRQWTDR   250
251   IMEEFFPQGD   RERERGMEIS   PMCDKHNASV   EKSQVGFIDY   IVHPLWETWA   300
301   DLVHPDAQDI   LDTLEDNREW   YQSTIPQS       350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
184_ASP TYR 8.3kJPN
chr19:10568755 		-
- 0.0001 -
205_ASN SER 8.3kJPN
chr1:66828891 		-
- 0.0001 -
207_ALA VAL 8.3kJPN
chr19:18329802 		rs772270728
- 0.0001 -
213_ARG GLN gnomAD
chr19:18329784 		rs2229228
- 0.290054 -
213_ARG TRP gnomAD
chr19:18329785 		rs11879710
- 0.00571006 -
213_ARG GLN 8.3kJPN
chr19:18329784 		rs2229228
- 0.1442 -
233_ARG CYS gnomAD
chr19:10570295 		rs201196140
- 0.000103517 -
243_MET ILE 8.3kJPN
chr19:10570327 		-
- 0.0001 -
248_ASP GLY 8.3kJPN
chr1:66829160 		-
- 0.0001 -
252_ALA THR 8.3kJPN
chr19:10570352 		rs183936414
- 0.0007 -
253_ASN SER gnomAD
chr19:18329223 		rs113176090
- 0.000111362 -
254_VAL MET 8.3kJPN
chr19:10570358 		-
- 0.0001 -
259_SER ARG gnomAD
chr1:66829194 		rs146166974
- 0.000195553 -
266_ALA VAL 8.3kJPN
chr1:66829214 		-
- 0.0001 -
275_THR ALA 8.3kJPN
chr19:18329158 		-
- 0.0001 -
301_HIS ARG 8.3kJPN
chr19:18328994 		-
- 0.0001 -
313_ASN ASP 8.3kJPN
chr19:18328959 		-
- 0.0001 -
314_SER PRO 8.3kJPN
chr5:58273170 		-
- 0.0001 -
336_LYS ARG gnomAD
chr19:10572271 		rs141379029
- 0.000369887 -
354_ARG TRP gnomAD
chr19:10572324 		rs146986676
- 0.00040994 -
364_MET LEU 8.3kJPN
chr19:10572354 		rs776679347
- 0.0002 -
382_THR PRO VAR_068245 rs397514467
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
382_THR PRO ClinVar
chr5:58272248 		rs397514467
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
385_GLU ALA VAR_069453 -
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
390_THR PRO ClinVar
chr5:58272224 		rs2153305991
Likely pathogenic - not provided [MedGen:C3661900]
400_TYR CYS ClinVar
chr5:58272193 		rs1554033904
Likely pathogenic - not provided [MedGen:CN517202]
402_ASP ASN 8.3kJPN
chr1:66833737 		rs749156051
- 0.0001 -
403_ARG GLN gnomAD
chr19:18324185 		rs371170617
- 0.00034246 -
408_ARG GLN gnomAD
chr19:10574476 		rs200669683
- 0.000234837 -
416_LEU VAL 8.3kJPN
chr19:18322721 		-
- 0.0001 -
418_ASN THR 8.3kJPN
chr19:10574506 		rs758029716
- 0.0005 -
420_THR PRO 8.3kJPN
chr19:10574511 		rs1221315322
- 0.0011 -
422_PRO LEU gnomAD
chr19:18322702 		rs149614671
- 0.000242628 -
422_PRO LEU 8.3kJPN
chr19:18322702 		rs149614671
- 0.0005 -
431_ASP GLU gnomAD
chr1:66834547 		rs141437989
- 0.000422873 -
431_ASP GLU 8.3kJPN
chr1:66834547 		rs141437989
- 0.0001 -
432_ARG TRP 8.3kJPN
chr5:58271588 		rs775209507
- 0.0001 -
439_ARG CYS gnomAD
chr5:58271567 		rs371950648
- 0.000112275 -
445_ARG TRP 8.3kJPN
chr1:66834587 		rs201667673
- 0.0001 -
445_ARG HIS 8.3kJPN
chr19:10574587 		rs373223236
- 0.0002 -
446_GLU ALA ClinVar
chr5:58271545 		rs387906744
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
449_LEU PRO 8.3kJPN
chr19:18322621 		-
- 0.0001 -
454_MET ILE 8.3kJPN
chr19:10574615 		rs1340115666
- 0.0001 -
460_ALA PRO 8.3kJPN
chr19:10574631 		-
- 0.0001 -
468_GLY ASP VAR_069454 rs397514469
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
468_GLY ASP ClinVar
chr5:58270903 		rs397514469
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
473_ILE THR VAR_069455 rs587777188
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
473_ILE THR ClinVar
chr5:58270888 		rs587777188
Pathogenic - Acrodysostosis 2 with or without hormone resistance|not provided [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651|MedGen:C3661900]
473_ILE THR 8.3kJPN
chr19:18322067 		-
- 0.0001 -
479_GLU GLY ClinVar
chr5:58270870 		rs1743358464
Likely pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
485_VAL ILE 8.3kJPN
chr5:58270853 		rs192644692
- 0.0001 -
491_GLU LYS 8.3kJPN
chr19:10577635 		-
- 0.0001 -
495_THR SER 8.3kJPN
chr1:66838080 		rs779182342
- 0.0003 -
504_GLN HIS 8.3kJPN
chr5:58270794 		-
- 0.0001 -
508_ARG GLN gnomAD
chr19:10577687 		rs146370645
- 0.00111828 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.