PDB ID 1MQ4     CHAIN A
Protein name AURORA-RELATED KINASE 1
Uniprot Accession O14965
The number of similar proteins 201
The number of binding states 11
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1MQ4 (CHAIN: A)
1 Monomeric state
2 8SSP  
3 P04198  
4 Q8JJ25  
5 Q9Y6A5  
6 Q9ULW0  
7 Q9ULW0  
8 Q8TEP8   Q8TEP8  
9 O14965   6C83   6C83  
10 O14965   Q9ULW0   Q9ULW0  
11 O14965   O14965   O14965  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   GAMGSKRQWA   LEDFEIGRPL   GKGKFGNVYL   AREKQSKFIL   ALKVLFKAQL   50
51   EKAGVEHQLR   REVEIQSHLR   HPNILRLYGY   FHDATRVYLI   LEYAPLGTVY   100
101   RELQKLSKFD   EQRTATYITE   LANALSYCHS   KRVIHRDIKP   ENLLLGSAGE   150
151   LKIADFGWSV   HAPSSRRTTL   CGTLDYLPPE   MIEGRMHDEK   VDLWSLGVLC   200
201   YEFLVGKPPF   EANTYQETYK   RISRVEFTFP   DFVTEGARDL   ISRLLKHNPS   250
251   QRPMLREVLE   HPWITANSSK   PS       300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
155_SER ARG VAR_041128 -
US - A colorectal adenocarcinoma sample
174_VAL MET VAR_041129 -
US - A metastatic melanoma sample
174_VAL ALA 8.3kJPN
chr20:54958086 		-
- 0.0001 -
189_ARG TRP 8.3kJPN
chr20:54958042 		rs779964295
- 0.0001 -
223_GLN LYS 8.3kJPN
chr20:54956527 		rs1217224639
- 0.0006 -
279_VAL ILE 8.3kJPN
chr20:54948483 		-
- 0.0002 -
305_MET LYS 8.3kJPN
chr20:54945656 		-
- 0.0002 -
309_LYS GLU 8.3kJPN
chr20:54945645 		-
- 0.0001 -
310_VAL MET 8.3kJPN
chr20:54945642 		-
- 0.0001 -
343_ARG GLN gnomAD
chr20:54945542 		rs200181472
- 0.000170986 -
343_ARG TRP 8.3kJPN
chr20:54945543 		rs774552788
- 0.0001 -
346_PHE LEU ClinVar
chr20:54945388 		rs1455074519
Likely pathogenic - Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443]
373_MET VAL VAR_041130 rs33923703
LB/B - -
373_MET VAL gnomAD
chr20:54945309 		rs33923703
- 0.0187479 -
373_MET VAL 8.3kJPN
chr20:54945309 		rs33923703
- 0.0001 -
386_ASN HIS gnomAD
chr20:54945270 		rs763051712
- 0.000131238 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.