PDB ID 1MX9     CHAIN A
Protein name liver Carboxylesterase I
Uniprot Accession P23141
The number of similar proteins 55
The number of binding states 3
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
1MX9 (CHAIN: A)
1 P23141   P23141   P23141  
2 Monomeric state
3 P23141   P23141  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   HPSSPPVVDT   VHGKVLGKFV   SLEGFAQPVA   IFLGIPFAKP   PLGPLRFTPP   50
51   QPAEPWSFVK   NATSYPPMCT   QDPKAGQLLS   ELFTNRKENI   PLKLSEDCLY   100
101   LNIYTPADLT   KKNRLPVMVW   IHGGGLMVGA   ASTYDGLALA   AHENVVVVTI   150
151   QYRLGIWGFF   STGDEHSRGN   WGHLDQVAAL   RWVQDNIASF   GGNPGSVTIF   200
201   GESAGGESVS   VLVLSPLAKN   LFHRAISESG   VALTSVLVKK   GDVKPLAEQI   250
251   AITAGCKTTT   SAVMVHCLRQ   KTEEELLETT   LKMKFLSLDL   QGDPRESQPL   300
301   LGTVIDGMLL   LKTPEELQAE   RNFHTVPYMV   GINKQEFGWL   IPMLMSYPLS   350
351   EGQLDQKTAM   SLLWKSYPLV   CIAKELIPEA   TEKYLGGTDD   TVKKKDLFLD   400
401   LIADVMFGVP   SVIVARNHRD   AGAPTYMYEF   QYRPSFSSDM   KPKTVIGDHG   450
451   DELFSVFGAP   FLKEGASEEE   IRLSKMVMKF   WANFARNGNP   NGEGLPHWPE   500
501   YNQKEGYLQI   GANTQAAQKL   KDKEVAFWTN   LFAKKAVEKP   PQTEHIEL   550

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
1022_SER LEU 8.3kJPN
chr16:55862871
rs142474691
- 0.0001 -
1032_LYS ASN 8.3kJPN
chr16:55862840
-
- 0.0001 -
1034_LEU ARG gnomAD
chr16:55862835
rs749254726
- 0.000255814 -
1038_VAL ILE 8.3kJPN
chr16:55862824
rs3826192
- 0.1189 -
1044_ALA VAL gnomAD
chr16:55862805
rs142469038
- 0.000203111 -
1048_ALA VAL 8.3kJPN
chr16:55862793
-
- 0.0001 -
1049_ILE VAL 8.3kJPN
chr16:55862791
rs3826193
- 0.1027 -
1068_PRO LEU gnomAD
chr16:55862733
rs757329400
- 0.000123265 -
1068_PRO SER 8.3kJPN
chr16:55862734
rs1158400665
- 0.0001 -
1075_SER ASN VAR_014314 rs2307240
LB/B - -
1075_SER ASN gnomAD
chr16:55862712
rs2307240
- 0.0486827 -
1075_SER ASN 8.3kJPN
chr16:55862712
rs2307240
- 0.0425 -
1078_LYS ARG 8.3kJPN
chr16:55862703
rs373547343
- 0.0001 -
1079_ASN ASP 8.3kJPN
chr16:55862701
rs773058212
- 0.0007 -
1082_SER LEU 8.3kJPN
chr16:55862691
rs62028647
- 0.1819 -
1086_MET VAL 8.3kJPN
chr16:55862680
-
- 0.0001 -
1093_ALA VAL gnomAD
chr16:55860187
rs202111709
- 0.00011546 -
1094_GLY VAL 8.3kJPN
chr16:55860184
-
- 0.0001 -
1101_PHE LEU 8.3kJPN
chr16:55860162
rs750433997
- 0.0001 -
1103_ASN ASP 8.3kJPN
chr16:55860158
-
- 0.0003 -
1124_PRO SER 8.3kJPN
chr16:55860095
-
- 0.0001 -
1141_GLY ARG 8.3kJPN
chr16:55857577
rs778421449
- 0.0001 -
1142_GLY GLU ClinVar
chr16:55857573
rs121912777
Pathogenic - DRUG METABOLISM, ALTERED, CES1-RELATED [MedGen:C4748035,OMIM:618057]
1142_GLY VAL 8.3kJPN
chr16:55857573
rs121912777
- 0.0002 -
1143_GLY GLU VAR_046954 rs71647871
LB/B - -
1143_GLY GLU gnomAD
chr16:55857570
rs71647871
- 0.010918 -
1147_GLY CYS gnomAD
chr16:55857559
rs146456965
- 0.000433817 -
1148_ALA VAL gnomAD
chr16:55857555
rs369026668
- 0.000111433 -
1150_SER PRO 8.3kJPN
chr16:55857550
-
- 0.0001 -
1158_ALA VAL gnomAD
chr16:55857525
rs202121317
- 0.00743687 -
1158_ALA VAL 8.3kJPN
chr16:55857525
rs202121317
- 0.0003 -
1167_THR SER gnomAD
chr16:55857498
rs147694791
- 0.00344171 -
1167_THR SER 8.3kJPN
chr16:55857498
rs147694791
- 0.0001 -
1173_GLY ASP 8.3kJPN
chr16:55857480
rs4784575
- 0.0622 -
1174_ILE THR gnomAD
chr16:55857477
rs751365501
- 0.000183397 -
1176_GLY ARG 8.3kJPN
chr16:55857472
-
- 0.0001 -
1179_SER ASN 8.3kJPN
chr16:55857462
-
- 0.0001 -
1186_ARG PRO gnomAD
chr16:55855413
rs60054861
- 0.0107501 -
1186_ARG GLN gnomAD
chr16:55855413
rs60054861
- 0.00190317 -
1186_ARG PRO 8.3kJPN
chr16:55855413
rs60054861
- 0.0002 -
1186_ARG TRP 8.3kJPN
chr16:55855414
rs200227274
- 0.0001 -
1190_GLY CYS gnomAD
chr16:55855402
rs150241462
- 0.000274605 -
1197_ALA THR 8.3kJPN
chr16:55855381
-
- 0.0001 -
1199_ARG HIS VAR_014594 rs2307243
LB/B - -
1199_ARG HIS gnomAD
chr16:55855374
rs2307243
- 0.000688305 -
1199_ARG HIS 8.3kJPN
chr16:55855374
rs2307243
- 0.0001 -
1203_ASP GLU VAR_014595 rs2307227
LB/B - -
1203_ASP GLU gnomAD
chr16:55855361
rs2307227
- 0.0326631 -
1203_ASP GLU 8.3kJPN
chr16:55855361
rs2307227
- 0.0101 -
1212_PRO SER 8.3kJPN
chr16:55855336
-
- 0.0001 -
1220_GLU GLY gnomAD
chr16:55855311
rs200707504
- 0.000361953 -
1220_GLU GLY 8.3kJPN
chr16:55855311
rs200707504
- 0.0091 -
1242_ARG TRP 8.3kJPN
chr16:55854358
rs376173751
- 0.0004 -
1249_VAL MET 8.3kJPN
chr16:55854337
rs778524104
- 0.0001 -
1264_LEU PHE 8.3kJPN
chr16:55854290
-
- 0.0001 -
1269_ALA SER gnomAD
chr16:55853545
rs115629050
- 0.0326835 -
1269_ALA SER 8.3kJPN
chr16:55853545
rs115629050
- 0.0104 -
1272_ALA SER 8.3kJPN
chr16:55853536
rs1567499789
- 0.0001 -
1277_THR ALA 8.3kJPN
chr16:55853521
rs200489319
- 0.0002 -
1284_HIS GLN gnomAD
chr16:55853498
rs114119971
- 0.00449884 -
1287_ARG LEU gnomAD
chr16:55853490
rs560426140
- 0.000131271 -
1287_ARG TER 8.3kJPN
chr16:55853491
rs144078935
- 0.0004 -
1290_THR MET 8.3kJPN
chr16:55853481
rs202001817
- 0.0007 -
1297_THR MET 8.3kJPN
chr16:55853460
rs767343447
- 0.0001 -
1302_LYS GLU 8.3kJPN
chr16:55850874
rs537106281
- 0.0033 -
1309_GLN PRO 8.3kJPN
chr16:55850852
-
- 0.0001 -
1339_ARG GLY 8.3kJPN
chr16:55846883
-
- 0.0001 -
1340_ASN LYS gnomAD
chr16:55846878
rs576295379
- 0.00075164 -
1347_MET VAL gnomAD
chr16:55846859
rs145135221
- 0.000258472 -
1349_GLY ARG 8.3kJPN
chr16:55846853
rs757978769
- 0.0001 -
1366_TYR CYS gnomAD
chr16:55844909
rs146595460
- 0.000804232 -
1377_THR SER gnomAD
chr16:55844877
rs762507008
- 0.00011143 -
1379_MET VAL gnomAD
chr16:55844871
rs140704082
- 0.00103065 -
1399_ALA THR 8.3kJPN
chr16:55844549
-
- 0.0001 -
1404_LEU PHE 8.3kJPN
chr16:55844532
-
- 0.0001 -
1405_GLY GLU 8.3kJPN
chr16:55844530
-
- 0.0001 -
1421_ILE ARG 8.3kJPN
chr16:55844482
rs748876242
- 0.0001 -
1432_ILE THR gnomAD
chr16:55844449
rs114277361
- 0.000111361 -
1433_VAL ALA 8.3kJPN
chr16:55844446
-
- 0.0001 -
1435_ARG GLY 8.3kJPN
chr16:55844441
rs376976316
- 0.0004 -
1438_ARG LYS 8.3kJPN
chr16:55844431
-
- 0.0005 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.