PDB ID 1N6L     CHAIN A
Protein name Ras-related protein Rab-5A
Uniprot Accession P20339
The number of similar proteins 19
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1N6L (CHAIN: A)
1 Monomeric state
2 Q9UJ41  
3 Q15075  
4 Q5ZRP9  
5 Q15276   Q15276  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GNKICQFKLV   LLGESPVGKS   SLVLRFVKGQ   FHEFQESTIG   AAFLTQTVCL   50
51   DDTTVKFEIW   DTAGQERYHS   LAPMYYRGAQ   AAIVVYDITN   EESFARAKNW   100
101   VKELQRQASP   NIVIALSGNK   ADLANKRAVD   FQEAQSYADD   NSLLFMETSA   150
151   KTSMNVNEIF   MAIAKKLPKN         200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
26_LEU VAL 8.3kJPN
chr3:19992466 		-
- 0.0001 -
36_LEU VAL 8.3kJPN
chr17:40282412 		-
- 0.0001 -
37_VAL ALA 8.3kJPN
chr3:19992500 		rs772319638
- 0.0001 -
39_ARG SER 8.3kJPN
chr12:56380859 		-
- 0.0001 -
59_THR ILE 8.3kJPN
chr17:40280806 		-
- 0.0001 -
60_GLN ARG 8.3kJPN
chr3:20017108 		-
- 0.0001 -
62_VAL ILE gnomAD
chr12:56383751 		rs531655278
- 0.000107361 -
97_ILE VAL gnomAD
chr12:56383856 		rs146500812
- 0.000143355 -
97_ILE VAL 8.3kJPN
chr12:56383856 		rs146500812
- 0.0002 -
101_ASP ASN 8.3kJPN
chr12:56383868 		rs781238057
- 0.0001 -
103_THR ILE 8.3kJPN
chr12:56383875 		-
- 0.0002 -
104_ASN HIS 8.3kJPN
chr12:56383877 		-
- 0.0001 -
109_ALA VAL 8.3kJPN
chr17:40280391 		-
- 0.0003 -
120_ARG GLN 8.3kJPN
chr12:56384509 		rs781438127
- 0.0001 -
123_SER ARG 8.3kJPN
chr12:56384517 		-
- 0.0001 -
125_ASN LYS gnomAD
chr3:20017598 		rs140005569
- 0.000163658 -
129_ALA SER 8.3kJPN
chr12:56384535 		-
- 0.0001 -
148_ALA VAL gnomAD
chr3:20019806 		rs200242114
- 0.000599286 -
148_ALA THR 8.3kJPN
chr3:20019805 		-
- 0.0001 -
150_ALA PRO gnomAD
chr12:56385153 		rs201470751
- 0.00019885 -
177_ILE THR 8.3kJPN
chr12:56385235 		-
- 0.0001 -
178_ALA ASP 8.3kJPN
chr3:20025200 		-
- 0.0001 -
179_LYS GLU 8.3kJPN
chr3:20025202 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.