PDB ID 1NHE     CHAIN B
Protein name BETA-1,4-GALACTOSYLTRANSFERASE
Uniprot Accession P08037
The number of similar proteins 21
The number of binding states 3
The number of binding partners 2

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1NHE (CHAIN: B)
1 P29752  
2 Monomeric state
3 P08037  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   ASXTGGQQXG   RGSSLTACPE   ESPLLVGPXL   IEFNIPVDLK   LVEQQNPKVK   50
51   LGGRYTPXDC   ISPHKVAIII   PFRNRQEHLK   YWLYYLHPIL   QRQQLDYGIY   100
101   VINQAGESXF   NRAKLLNVGF   KEALKDYDYN   CFVFSDVDLI   PXNDHNTYRC   150
151   FSQPRHISVA   XDKFGFSLPY   VQYFGGVSAL   SKQQFLSING   FPNNYWGWGG   200
201   EDDDIYNRLA   FRGXSVSRPN   AVIGKCRXIR   HSRDKKNEPN   PQRFDRIAHT   250
251   KETXLSDGLN   SLTYXVLEVQ   RYPLYTKITV   DIGTPS     300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
134_CYS TYR 8.3kJPN
chr9:33166779 		-
- 0.0001 -
135_PRO LEU gnomAD
chr9:33166776 		rs150774756
- 0.000103712 -
158_VAL MET 8.3kJPN
chr9:33135375 		rs750518389
- 0.0001 -
164_ASN ASP 8.3kJPN
chr9:33135357 		rs774489888
- 0.0002 -
170_ARG CYS 8.3kJPN
chr9:33135339 		rs770241599
- 0.0001 -
175_ASP GLU gnomAD
chr9:33135322 		rs146996656
- 0.000135204 -
178_SER CYS 8.3kJPN
chr9:33135314 		-
- 0.0001 -
189_ARG CYS 8.3kJPN
chr9:33135282 		rs142441831
- 0.0001 -
197_TYR TER ClinVar
chr9:33135256 		rs1840249855
Pathogenic - B4GALT1-congenital disorder of glycosylation [MONDO:MONDO:0011772,MedGen:C2931009,OMIM:607091,Orphanet:79332]
221_ALA VAL 8.3kJPN
chr9:33120603 		rs780815290
- 0.0016 -
238_GLU LYS 8.3kJPN
chr9:33120553 		-
- 0.0001 -
257_PRO ALA gnomAD
chr9:33120496 		rs201417912
- 0.000103395 -
261_HIS ARG gnomAD
chr9:33120483 		rs9169
- 0.000401622 -
268_SER ALA 8.3kJPN
chr9:33120463 		rs755251855
- 0.0001 -
302_LEU VAL gnomAD
chr9:33116056 		rs150249236
- 0.000111357 -
305_ASN SER 8.3kJPN
chr9:33116046 		rs376696269
- 0.0001 -
333_SER ALA 8.3kJPN
chr9:33113851 		-
- 0.0002 -
342_CYS GLY 8.3kJPN
chr9:33113824 		-
- 0.0007 -
356_ASN SER ClinVar
chr9:33113781 		-
Pathogenic - Combined low LDL and fibrinogen [MONDO:MONDO:0957260,MedGen:C5830484,OMIM:620364]
385_VAL LEU 8.3kJPN
chr9:33113508 		-
- 0.0001 -
397_ASP TYR 8.3kJPN
chr9:33113472 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.