PDB ID 1U81     CHAIN A
Protein name ADP-ribosylation factor 1
Uniprot Accession P84077
The number of similar proteins 20
The number of binding states 7
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1U81 (CHAIN: A)
1 Monomeric state
2 P47102  
3 P84079  
4 Q8ZPY9  
5 Q8NI19  
6 Q9UJY5  
7 6II6  

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Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MRILMVGLDA   AGKTTILYKL   KLGEIVTTIP   TIGFNVETVE   YKNISFTVWD   50
51   VGGQDKIRPL   WRHYFQNTQG   LIFVVDSNDR   ERVNEAREEL   MRMLAEDELR   100
101   DAVLLVFANK   QDLPNAMNAA   EITDKLGLHS   LRHRNWYIQA   TCATSGDGLY   150
151   EGLDWLSNQL   RNQK         200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
19_ARG CYS ClinVar
chr1:228284870 		rs2124857065
Likely pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
32_THR ASN ClinVar
chr12:49334784 		-
Pathogenic - Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Kyphosis [Human Phenotype Ontology:HP:0002769,Human Phenotype Ontology:HP:0002808,Human Phenotype Ontology:HP:0003314,MedGen:C0022821]; Atrophy/Degeneration affecting the central nervous system [Human Phenotype Ontology:HP:0007367,MedGen:C4024899]
33_ILE VAL 8.3kJPN
chr7:127229166 		rs767832041
- 0.0001 -
35_TYR HIS VAR_081272 rs879036238
LP/P - Periventricular nodular heterotopia 8 (PVNH8) [MIM:618185]
35_TYR HIS ClinVar
chr1:228284918 		rs879036238
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
35_TYR ASP ClinVar
chr1:228284918 		rs879036238
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
36_LYS ARG 8.3kJPN
chr7:127229176 		-
- 0.0001 -
48_THR ILE ClinVar
chr1:228284958 		rs1571844539
Likely pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
51_PHE LEU ClinVar
chr1:228285047 		rs2124857427
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
51_PHE LEU ClinVar
chr1:228285045 		rs2124857424
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
60_ASN HIS 8.3kJPN
chr3:57569705 		-
- 0.0001 -
67_ASP VAL ClinVar
chr12:49333839 		-
Pathogenic - Microcephaly [Human Phenotype Ontology:HP:0000252,Human Phenotype Ontology:HP:0001366,Human Phenotype Ontology:HP:0005485,Human Phenotype Ontology:HP:0005489,Human Phenotype Ontology:HP:0005497,MONDO:MONDO:0001149,MedGen:C4551563]; Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Scoliosis [Human Phenotype Ontology:HP:0002650,Human Phenotype Ontology:HP:0002770,Human Phenotype Ontology:HP:0003303,Human Phenotype Ontology:HP:0003317,Human Phenotype Ontology:HP:0003415,MONDO:MONDO:0005392,MedGen:C0036439]; Dystonic disorder [Human Phenotype Ontology:HP:0001332,Human Phenotype Ontology:HP:0002328,MONDO:MONDO:0003441,MedGen:C0013421]; Atrophy/Degeneration affecting the central nervous system [Human Phenotype Ontology:HP:0007367,MedGen:C4024899]
83_GLN ARG 8.3kJPN
chr7:127229638 		-
- 0.0001 -
93_ASP ASN ClinVar
chr12:49333545 		-
Pathogenic/Likely pathogenic - Hypotonia [Human Phenotype Ontology:HP:0001252,MedGen:C0026827]; Microcephaly [Human Phenotype Ontology:HP:0000252,Human Phenotype Ontology:HP:0001366,Human Phenotype Ontology:HP:0005485,Human Phenotype Ontology:HP:0005489,Human Phenotype Ontology:HP:0005497,MONDO:MONDO:0001149,MedGen:C4551563]; Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Atrophy/Degeneration affecting the central nervous system [Human Phenotype Ontology:HP:0007367,MedGen:C4024899]; Pectus excavatum|12 conditions [Human Phenotype Ontology:HP:0000767,Human Phenotype Ontology:HP:0006613,Human Phenotype Ontology:HP:0006617,MONDO:MONDO:0008213,MedGen:C2051831,OMIM:169300|12 conditions]
97_ARG TRP 8.3kJPN
chr7:127230150 		rs367999369
- 0.0001 -
99_ARG HIS VAR_081273 -
US - Periventricular nodular heterotopia 8 (PVNH8) [MIM:618185]
99_ARG HIS ClinVar
chr1:228285328 		rs1558087712
Pathogenic/Likely pathogenic - Periventricular nodular heterotopia 8|not provided [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185|MedGen:C3661900]
99_ARG CYS ClinVar
chr1:228285327 		rs2124857939
Likely pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
102_GLU LYS 8.3kJPN
chr3:57563069 		-
- 0.0001 -
117_ARG GLN 8.3kJPN
chr12:49333472 		rs752332270
- 0.0001 -
125_ALA THR 8.3kJPN
chr1:228285405 		rs1382592951
- 0.0001 -
127_LYS GLU VAR_081274 -
LP/P - Periventricular nodular heterotopia 8 (PVNH8) [MIM:618185]
127_LYS GLU ClinVar
chr1:228285411 		rs1558087795
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
127_LYS GLU ClinVar
chr12:49333443 		-
Pathogenic - 7 conditions [7 conditions]
131_PRO ARG ClinVar
chr1:228285560 		rs2124858360
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
131_PRO LEU ClinVar
chr1:228285560 		rs2124858360
Pathogenic - Periventricular nodular heterotopia 8 [MONDO:MONDO:0032588,MedGen:C4748602,OMIM:618185]
133_ALA THR 8.3kJPN
chr7:127231083 		rs201108741
- 0.0001 -
140_THR PRO 8.3kJPN
chr3:57561313 		-
- 0.0001 -
144_GLY ALA 8.3kJPN
chr7:127231117 		-
- 0.0001 -
149_ARG HIS 8.3kJPN
chr3:57561285 		rs777379437
- 0.0001 -
149_ARG CYS 8.3kJPN
chr3:57561286 		rs747265204
- 0.001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.