PDB ID 2AFM     CHAIN A
Protein name Glutaminyl-peptide cyclotransferase
Uniprot Accession Q16769
The number of similar proteins 29
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2AFM (CHAIN: A)
1 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   ASAWPEEKNY   HQPAILNSSA   LRQIAEGTSI   SEMWQNDLQP   LLIERYPGSP   50
51   GSYAARQHIM   QRIQRLQADW   VLEIDTFLSQ   TPYGYRSFSN   IISTLNPTAK   100
101   RHLVLACHYD   SKYFSHWNNR   VFVGATDSAV   PCAMMLELAR   ALDKKLLSLK   150
151   TVSDSKPDLS   LQLIFFDGEE   AFLHWSPQDS   LYGSRHLAAK   MASTPHPPGA   200
201   RGTSQLHGMD   LLVLLDLIGA   PNPTFPNFFP   NSARWFERLQ   AIEHELHELG   250
251   LLKDHSLEGR   YFQNYSYGGV   IQDDHIPFLR   RGVPVLHLIP   SPFPEVWHTM   300
301   DDNEENLDES   TIDNLNKILQ   VFVLEYLHL       350

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
33_ALA THR 8.3kJPN
chr2:37571971
rs11555863
- 0.0002 -
54_ARG TRP VAR_053956 rs2255991
LB/B - -
54_ARG TRP gnomAD
chr2:37579971
rs2255991
- 0.0970115 -
54_ARG TRP 8.3kJPN
chr2:37579971
rs2255991
- 0.3554 -
54_ARG GLN 8.3kJPN
chr2:37579972
rs542622681
- 0.0001 -
71_GLN ARG VAR_005569 rs895245310
LB/B - -
82_PRO ALA 8.3kJPN
chr2:37580055
-
- 0.0001 -
82_PRO HIS 8.3kJPN
chr2:37580056
-
- 0.0001 -
84_SER GLY gnomAD
chr2:37580061
rs373504469
- 0.00101462 -
87_ALA THR 8.3kJPN
chr2:37580070
-
- 0.0001 -
88_ARG HIS gnomAD
chr2:37580074
rs138792210
- 0.0029127 -
94_ARG GLN gnomAD
chr2:37586736
rs116518028
- 0.000267949 -
94_ARG GLN 8.3kJPN
chr2:37586736
rs116518028
- 0.0027 -
108_THR ASN 8.3kJPN
chr2:37586778
rs143642421
- 0.0001 -
126_THR ASN 8.3kJPN
chr2:37586832
rs777244922
- 0.0002 -
131_ALA THR 8.3kJPN
chr2:37586846
-
- 0.0001 -
132_LYS THR 8.3kJPN
chr2:37586850
rs759531203
- 0.0001 -
138_ALA SER 8.3kJPN
chr2:37586867
-
- 0.0002 -
151_ASN SER gnomAD
chr2:37586907
rs115355165
- 0.000508999 -
207_TRP ARG 8.3kJPN
chr2:37594447
-
- 0.0001 -
213_LEU PHE 8.3kJPN
chr2:37594465
-
- 0.0001 -
224_ALA PRO gnomAD
chr2:37594498
rs146420099
- 0.000514264 -
225_SER LEU 8.3kJPN
chr2:37594502
rs759201090
- 0.0002 -
249_LEU VAL 8.3kJPN
chr2:37596849
-
- 0.0001 -
256_THR MET 8.3kJPN
chr2:37596871
rs750310275
- 0.0001 -
290_GLU GLN 8.3kJPN
chr2:37599543
rs780619329
- 0.0001 -
325_PHE VAL gnomAD
chr2:37599857
rs139230874
- 0.000554403 -
327_GLU LYS gnomAD
chr2:37599863
rs34476437
- 0.000430725 -
327_GLU LYS 8.3kJPN
chr2:37599863
rs34476437
- 0.0049 -
338_ASN HIS gnomAD
chr2:37599896
rs139934664
- 0.00141041 -
353_VAL ALA gnomAD
chr2:37599942
rs116754028
- 0.000764759 -
360_HIS PRO VAR_053957 rs4670696
LB/B - -
360_HIS PRO gnomAD
chr2:37599963
rs4670696
- 0.108948 -
360_HIS PRO 8.3kJPN
chr2:37599963
rs4670696
- 0.4037 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.