PiSITE

PDB ID	2ALB	CHAIN	A
Protein name	Protein disulfide-isomerase A3
Uniprot Accession	P30101
The number of similar proteins	1
The number of binding states	1
The number of binding partners	0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	2ALB (CHAIN: A)
1	Monomeric state

Downdload

Molecule viewer

Only interaction residues

#binding
partners

0

Sequence information

1

SDVLELTDDN

FESRISDTGS

AGLMLVEFFA

PWCGHCKRLA

PEYEAAATRL

50

51

KGIVPLAKVD

CTANTNTCNK

YGVSGYPTLK

IFRDGEEAGA

YDGPRTADGI

100

101

VSHLKKQAGP

ASV

150

Variants

	Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
	9_ASP	TYR	gnomAD chr15:44038834	rs758327036	-	0.000105675	-
	14_ARG	LEU	gnomAD chr15:44038850	rs61734331	-	0.00132331	-
	17_ASP	TYR	8.3kJPN chr15:44038858	rs4080719	-	0.0004	-
	33_CYS	TYR	ClinVar chr15:44046024	rs1555455456	Likely pathogenic	-	Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]
	41_PRO	SER	8.3kJPN chr15:44046047	-	-	0.0001	-
	88_ALA	THR	gnomAD chr15:44048934	rs776448973	-	0.000159139	-
	88_ALA	THR	8.3kJPN chr15:44048934	rs776448973	-	0.0001	-
	102_SER	ASN	8.3kJPN chr15:44053634	rs760789393	-	0.0001	-
	107_GLN	HIS	8.3kJPN chr15:44053650	-	-	0.0001	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364