PDB ID 2APC     CHAIN A
Protein name Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Uniprot Accession P27115
The number of similar proteins 7
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2APC (CHAIN: A)
1 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   AVIPILVIAC   DRSTVRRCLD   KLLHYRPSAE   LFPIIVSQDC   GHEETAQVIA   50
51   SYGSAVTHIR   QPDLSNIAVQ   PDHRKFQGYY   KIARHYRWAL   GQIFHNFNYP   100
101   AAVVVEDDLE   VAPDFFEYFQ   ATYPLLKADP   SLWCVSAWND   NGKEQMVDSS   150
151   KPELLYRTDF   FPGLGWLLLA   ELWAELEPKW   PKAFWDDWMR   RPEQRKGRAC   200
201   VRPEISRTMT   FGRKGVSHGQ   FFDQHLKFIK   LNQQFVPFTQ   LDLSYLQQEA   250
251   YDRDFLARVY   GAPQLQVEKV   RTNDRKELGE   VRVQYTGRDS   FKAFAKALGV   300
301   MDDLKSGVPR   AGYRGIVTFL   FRGRRVHLAP   PQTWDGYDPS   WT   350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
138_PRO ARG 8.3kJPN
chr5:180219565 		-
- 0.0001 -
154_ILE VAL 8.3kJPN
chr5:180219518 		-
- 0.0001 -
173_ALA VAL gnomAD
chr5:180219460 		rs147082463
- 0.000271651 -
176_PRO LEU gnomAD
chr5:180219451 		rs141716191
- 0.000660995 -
176_PRO LEU 8.3kJPN
chr5:180219451 		rs141716191
- 0.0034 -
200_ARG TRP gnomAD
chr5:180219380 		rs777850285
- 0.000174037 -
225_ARG GLN gnomAD
chr5:180219304 		rs7726005
- 0.111557 -
225_ARG GLN 8.3kJPN
chr5:180219304 		rs7726005
- 0.2001 -
280_GLU TER 8.3kJPN
chr5:180219140 		-
- 0.0001 -
281_LEU ARG 8.3kJPN
chr5:180219136 		-
- 0.0001 -
282_GLU GLY 8.3kJPN
chr5:180219133 		-
- 0.0001 -
283_PRO ARG 8.3kJPN
chr5:180219130 		rs150019176
- 0.0001 -
285_TRP TER 8.3kJPN
chr5:180219123 		-
- 0.0001 -
287_LYS TER 8.3kJPN
chr5:180219119 		-
- 0.0001 -
288_ALA GLY 8.3kJPN
chr5:180219115 		-
- 0.0002 -
296_ARG GLN 8.3kJPN
chr5:180219091 		rs762037486
- 0.0001 -
306_ILE LEU gnomAD
chr5:180219062 		rs573544483
- 0.000177573 -
307_ARG CYS 8.3kJPN
chr5:180219059 		rs1420454585
- 0.0001 -
353_ARG TRP 8.3kJPN
chr5:180218921 		rs1020150778
- 0.0001 -
364_VAL ILE gnomAD
chr5:180218888 		rs148413292
- 0.000107396 -
371_GLN ARG 8.3kJPN
chr5:180218866 		-
- 0.0003 -
380_ARG TRP 8.3kJPN
chr5:180218840 		rs775650836
- 0.0002 -
389_GLN GLU 8.3kJPN
chr5:180218813 		-
- 0.0001 -
427_ARG TRP 8.3kJPN
chr5:180218699 		rs151044774
- 0.0004 -
430_ARG CYS 8.3kJPN
chr5:180218690 		rs1183965942
- 0.0001 -
437_LEU PRO gnomAD
chr5:180218668 		rs634501
- 0.713416 -
437_LEU PRO 8.3kJPN
chr5:180218668 		rs634501
- 0.572 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.