PDB ID 2AZT     CHAIN A
Protein name Glycine N-methyltransferase
Uniprot Accession Q14749
The number of similar proteins 50
The number of binding states 3
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2AZT (CHAIN: A)
1 Q14749  
2 P13255   P13255  
3 P13255   P13255   P13255  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MVDSVYRTRS   LGVAAEGLPD   QYADGEAARV   WQLYIGDTRS   RTAEYKAWLL   50
51   GLLRQHGCQR   VLDVACGTGV   DSIMLVEEGF   SVTSVDASDK   MLKYALKERW   100
101   NRRHEPAFDK   WVIEEANWMT   LDKDVPQSAE   GGFDAVICLG   NSFAHLPDCK   150
151   GDQSEHRLAL   KNIASMVRAG   GLLVIDNRNY   DHILSTGCAP   PGKNIYYKSD   200
201   LTKDVTTSVL   IVNNKAHMVT   LDYTVQVPGA   GQDGSPGLSK   FRLSYYPHCL   250
251   ASFTELLQAA   FGGKCQHSVL   GDFKPYKPGQ   TYIPCYFIHV   LKRTD   300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
29_VAL MET gnomAD
chr6:42928593 		rs538620810
- 0.000149722 -
41_THR PRO 8.3kJPN
chr6:42928629 		-
- 0.0019 -
49_LEU PRO VAR_012766 rs121907888
LP/P - Glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]
49_LEU PRO ClinVar
chr6:42928654 		rs121907888
Pathogenic - Glycine N-methyltransferase deficiency [MONDO:MONDO:0011698,MedGen:C1847720,OMIM:606664,Orphanet:289891]
81_VAL MET 8.3kJPN
chr6:42929987 		-
- 0.0001 -
96_LYS GLU 8.3kJPN
chr6:42930032 		-
- 0.0001 -
100_ASN ASP gnomAD
chr6:42930044 		rs746552607
- 0.000111362 -
102_ARG TRP 8.3kJPN
chr6:42930050 		rs749599022
- 0.0001 -
102_ARG GLN 8.3kJPN
chr6:42930051 		rs781167464
- 0.0002 -
106_ALA THR gnomAD
chr6:42930062 		rs535188125
- 0.00144861 -
109_LYS ASN 8.3kJPN
chr6:42930073 		rs759573326
- 0.0001 -
123_ASP GLY 8.3kJPN
chr6:42930536 		-
- 0.0001 -
124_VAL MET gnomAD
chr6:42930538 		rs143043221
- 0.000373766 -
140_ASN SER VAR_019840 rs864321678
LP/P - Glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]
140_ASN SER ClinVar
chr6:42930587 		rs864321678
Pathogenic - Glycine N-methyltransferase deficiency [MONDO:MONDO:0011698,MedGen:C1847720,OMIM:606664,Orphanet:289891]
150_GLY VAL 8.3kJPN
chr6:42930810 		rs1463626619
- 0.0001 -
155_HIS PRO gnomAD
chr6:42930825 		rs138085632
- 0.000136054 -
156_ARG TRP gnomAD
chr6:42930827 		rs142613217
- 0.000220159 -
156_ARG GLN gnomAD
chr6:42930828 		rs563826316
- 0.000128069 -
156_ARG GLN 8.3kJPN
chr6:42930828 		rs563826316
- 0.0001 -
176_HIS ASN gnomAD
chr6:42930887 		rs121907889
- 0.000406822 -
176_HIS ARG 8.3kJPN
chr6:42930888 		rs201256313
- 0.0001 -
181_HIS PRO 8.3kJPN
chr6:42930903 		rs200543916
- 0.0001 -
211_VAL GLY 8.3kJPN
chr6:42931106 		-
- 0.0001 -
236_GLY SER 8.3kJPN
chr6:42931180 		rs755716132
- 0.0001 -
241_ARG TRP 8.3kJPN
chr6:42931280 		rs946974235
- 0.0001 -
260_PHE LEU gnomAD
chr6:42931339 		rs201991849
- 0.000107377 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.