PDB ID 2BCV     CHAIN A
Protein name DNA polymerase lambda
Uniprot Accession Q9UGP5
The number of similar proteins 83
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2BCV (CHAIN: A)
1 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   MAQPSSQKAT   NHNLHITEKL   EVLAKAYSVQ   GDKWRALGYA   KAINALKSFH   50
51   KPVTSYQEAC   SIPGIGKRMA   EKIIEILESG   HLRKLDHISE   SVPVLELFSN   100
101   IWGAGTKTAQ   MWYQQGFRSL   EDIRSQASLT   TQQAIGLKHY   SDFLERMPRE   150
151   EATEIEQTVQ   KAAQAFNSGL   LCVACGSYRR   GKATCGDVDV   LITHPDGRSH   200
201   RGIFSRLLDS   LRQEGFLTDD   LVSQEENGQQ   QKYLGVCRLP   GPGRRHRRLD   250
251   IIVVPYSEFA   CALLYFTGSA   HFNRSMRALA   KTKGMSLSEH   ALSTAVVRNT   300
301   HGCKVGPGRV   LPTPTEKDVF   RLLGLPYREP   AERDW     350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
260_LEU ARG 8.3kJPN
chr10:103344471 		rs752415385
- 0.0004 -
273_LYS GLN 8.3kJPN
chr10:103344433 		-
- 0.0001 -
284_ASN SER 8.3kJPN
chr10:103344399 		rs745910994
- 0.0001 -
301_SER ARG gnomAD
chr10:103343427 		rs529724242
- 0.000326464 -
303_PRO SER gnomAD
chr10:103343423 		rs142726673
- 0.000784161 -
308_ARG GLN 8.3kJPN
chr10:103343407 		rs764560391
- 0.0005 -
308_ARG TRP 8.3kJPN
chr10:103343408 		rs376114934
- 0.0001 -
315_GLU ALA 8.3kJPN
chr10:103343386 		-
- 0.0002 -
323_ARG TRP 8.3kJPN
chr10:103343363 		rs760809916
- 0.0001 -
340_ASN SER 8.3kJPN
chr10:103343311 		rs999272431
- 0.0001 -
349_ALA THR 8.3kJPN
chr10:103343285 		-
- 0.0001 -
374_ALA THR 8.3kJPN
chr10:103342594 		-
- 0.0001 -
376_GLY SER gnomAD
chr10:103342588 		rs200623399
- 0.00019485 -
384_LEU PRO 8.3kJPN
chr10:103342563 		-
- 0.0001 -
414_ALA THR gnomAD
chr10:103340128 		rs543893064
- 0.000378016 -
420_ARG TRP 8.3kJPN
chr10:103340110 		rs374718867
- 0.0002 -
430_VAL MET 8.3kJPN
chr10:103340080 		rs765062611
- 0.0001 -
438_ARG TRP VAR_020269 rs3730477
LB/B - -
438_ARG TRP gnomAD
chr10:103340056 		rs3730477
- 0.167594 -
438_ARG GLN 8.3kJPN
chr10:103340055 		-
- 0.0001 -
438_ARG TRP 8.3kJPN
chr10:103340056 		rs3730477
- 0.0586 -
468_GLY ASP gnomAD
chr10:103339535 		rs149956893
- 0.000131908 -
485_ARG GLN gnomAD
chr10:103339484 		rs146653325
- 0.000646041 -
487_ARG GLN 8.3kJPN
chr10:103339478 		rs775811697
- 0.0001 -
488_ARG HIS 8.3kJPN
chr10:103339475 		rs373860780
- 0.0001 -
491_ILE VAL gnomAD
chr10:103339467 		rs138242344
- 0.000274854 -
497_SER ARG gnomAD
chr10:103339447 		rs145961723
- 0.000246918 -
500_ALA THR 8.3kJPN
chr10:103339440 		rs150453080
- 0.0002 -
549_ARG TER 8.3kJPN
chr10:103339293 		rs55978126
- 0.002 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.