PDB ID 2D06     CHAIN A
Protein name Sulfotransferase 1A1
Uniprot Accession P50225
The number of similar proteins 14
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2D06 (CHAIN: A)
1 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   MELIQDTSRP   PLEYVKGVPL   IKYFAEALGP   LQSFQARPDD   LLISTYPKSG   50
51   TTWVSQILDM   IYQGGDLEKC   HRAPIFMRVP   FLEFKAPGIP   SGMETLKDTP   100
101   APRLLKTHLP   LALLPQTLLD   QKVKVVYVAR   NAKDVAVSYY   HFYHMAKVHP   150
151   EPGTWDSFLE   KFMVGEVSYG   SWYQHVQEWW   ELSRTHPVLY   LFYEDMKENP   200
201   KREIQKILEF   VGHSLPEETV   DFMVQHTSFK   EMKKNPMTNY   TTVPQEFMDH   250
251   SISPFMRKGM   AGDWKTTFTV   AQNERFDADY   AEKMAGCSLS   FRSEL   300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
9_ARG CYS gnomAD
chr16:29472731 		rs752303630
- 0.00160348 -
9_ARG CYS gnomAD
chr16:30212074 		rs762151655
- 0.000500095 -
9_ARG HIS gnomAD
chr16:30212075 		rs1447149120
- 0.000111213 -
9_ARG CYS 8.3kJPN
chr16:28607227 		rs1174429714
- 0.0002 -
9_ARG CYS 8.3kJPN
chr16:29472731 		rs752303630
- 0.0001 -
10_PRO LEU gnomAD
chr16:28607223 		rs139593792
- 0.000309587 -
15_VAL MET gnomAD
chr16:29472749 		rs758881470
- 0.000110789 -
18_VAL GLY 8.3kJPN
chr16:28620124 		-
- 0.0001 -
19_PRO LEU gnomAD
chr16:28607196 		rs10797300
- 0.0994039 -
19_PRO LEU 8.3kJPN
chr16:28607196 		rs10797300
- 0.0001 -
22_LYS ARG gnomAD
chr16:28620112 		rs143603811
- 0.000471517 -
37_ARG GLN VAR_009302 rs72547527
LB/B - -
37_ARG GLN gnomAD
chr16:28620067 		rs72547527
- 0.000115592 -
37_ARG TRP gnomAD
chr16:28620068 		rs148045936
- 0.000195319 -
37_ARG GLN 8.3kJPN
chr16:30212159 		rs1158658024
- 0.0001 -
40_ASP ALA 8.3kJPN
chr16:30212168 		-
- 0.0001 -
44_SER ASN gnomAD
chr16:28607121 		rs145008170
- 0.000415064 -
44_SER ASN gnomAD
chr16:28620046 		rs199959449
- 0.000306942 -
48_LYS THR 8.3kJPN
chr16:28620034 		rs1450653678
- 0.0008 -
50_GLY SER 8.3kJPN
chr16:28607104 		rs766233374
- 0.002 -
50_GLY SER 8.3kJPN
chr16:28620029 		rs369692454
- - -
60_MET VAL gnomAD
chr16:28619895 		rs201317421
- 0.000135374 -
61_ILE VAL 8.3kJPN
chr16:29472991 		-
- 0.0001 -
62_TYR PHE gnomAD
chr16:28606960 		rs4987024
- 0.00960835 -
62_TYR PHE 8.3kJPN
chr16:28606960 		rs4987024
- 0.0005 -
65_GLY CYS 8.3kJPN
chr16:28619880 		-
- 0.0001 -
66_ASP ASN 8.3kJPN
chr16:29473006 		rs1373294800
- 0.0001 -
68_GLU ALA 8.3kJPN
chr16:30212356 		-
- 0.0001 -
72_ARG GLN 8.3kJPN
chr16:30212368 		rs1275077644
- 0.0001 -
78_ARG TRP 8.3kJPN
chr16:28619841 		rs201320226
- 0.0001 -
78_ARG TRP 8.3kJPN
chr16:30212385 		rs1204171913
- 0.0001 -
78_ARG GLN 8.3kJPN
chr16:30212386 		rs1270699829
- 0.0012 -
83_GLU LYS 8.3kJPN
chr16:28619826 		rs769477560
- 0.0001 -
85_ASN SER gnomAD
chr16:29473064 		rs1454206340
- 0.00010591 -
85_LYS GLU 8.3kJPN
chr16:28619820 		rs527273911
- 0.0003 -
86_VAL ALA gnomAD
chr16:28606888 		rs1126451
- 0.000723831 -
86_VAL ALA 8.3kJPN
chr16:28606888 		rs1126451
- 0.0103 -
86_ALA VAL 8.3kJPN
chr16:28619816 		rs72547525
- 0.0001 -
87_PRO SER gnomAD
chr16:30212412 		rs1477067521
- 0.00019607 -
98_ASN ASP gnomAD
chr16:28606768 		rs747728105
- 0.000314143 -
98_ASP ASN 8.3kJPN
chr16:28619692 		rs1228005503
- 0.0001 -
100_PRO LEU gnomAD
chr16:28619685 		rs142537541
- 0.000290515 -
100_PRO LEU gnomAD
chr16:30212541 		rs1358156071
- 0.000137503 -
100_PRO LEU 8.3kJPN
chr16:28619685 		rs142537541
- 0.0002 -
101_PRO SER gnomAD
chr16:29473200 		rs1394862373
- 0.000405723 -
101_PRO HIS gnomAD
chr16:29473201 		rs1460887051
- 0.00023592 -
101_PRO LEU gnomAD
chr16:29473201 		rs1460887051
- 0.00122249 -
101_PRO HIS gnomAD
chr16:30212544 		rs751527244
- 0.000472534 -
101_PRO LEU gnomAD
chr16:30212544 		rs751527244
- 0.00246111 -
102_PRO LEU 8.3kJPN
chr16:30212547 		rs1210653013
- 0.0001 -
103_ARG GLN gnomAD
chr16:28606752 		rs147555218
- 0.000222683 -
103_ARG TRP gnomAD
chr16:29473206 		rs1323862413
- 0.000106819 -
103_ARG GLN 8.3kJPN
chr16:30212550 		rs1448943588
- 0.0012 -
105_LEU PRO gnomAD
chr16:28619670 		rs200954146
- 0.000143262 -
113_LEU VAL 8.3kJPN
chr16:28619647 		rs144188544
- 0.0001 -
117_THR ALA 8.3kJPN
chr16:28606711 		rs528651850
- 0.0004 -
117_THR ILE 8.3kJPN
chr16:28619634 		-
- 0.0001 -
124_LYS ASN 8.3kJPN
chr16:30212614 		-
- 0.0002 -
130_ARG CYS 8.3kJPN
chr16:28604874 		rs775233545
- 0.0001 -
130_ARG HIS 8.3kJPN
chr16:28618382 		rs747252974
- 0.0001 -
132_ALA THR gnomAD
chr16:28618377 		rs138013613
- 0.000214939 -
134_ASP TYR 8.3kJPN
chr16:28618371 		rs1481596217
- 0.0001 -
147_LYS ASN gnomAD
chr16:28604821 		rs369978676
- 0.000127255 -
147_LYS GLU gnomAD
chr16:28604823 		rs765069200
- 0.000107369 -
148_VAL ALA 8.3kJPN
chr16:28604819 		rs1298621535
- 0.0001 -
151_GLU ASP VAR_028721 rs1042014
LB/B - -
151_GLU GLN VAR_057339 rs1042011
LB/B - -
156_ASP ASN 8.3kJPN
chr16:28618305 		rs775719447
- 0.0002 -
164_ALA VAL gnomAD
chr16:28604771 		rs142241142
- 0.00801692 -
165_GLY ARG gnomAD
chr16:28618278 		rs141878102
- 0.0001194 -
169_TYR HIS 8.3kJPN
chr16:28604662 		-
- 0.0001 -
169_TYR CYS 8.3kJPN
chr16:28618170 		rs759716692
- 0.0002 -
176_VAL GLY 8.3kJPN
chr16:28618149 		-
- 0.0002 -
177_GLN TER 8.3kJPN
chr16:28604638 		rs779420691
- 0.0004 -
180_TRP TER 8.3kJPN
chr16:28604627 		-
- 0.0001 -
184_ARG CYS 8.3kJPN
chr16:28604617 		rs146100761
- 0.0001 -
186_HIS TYR 8.3kJPN
chr16:28618120 		rs751668521
- 0.0011 -
196_MET ILE gnomAD
chr16:28618088 		rs138833811
- 0.00254791 -
198_GLU LYS 8.3kJPN
chr16:28618084 		rs748940168
- 0.0032 -
199_ASN TYR 8.3kJPN
chr16:28617557 		rs754074031
- 0.001 -
201_LYS ARG gnomAD
chr16:28603757 		rs150902793
- 0.000190903 -
201_LYS GLU 8.3kJPN
chr16:28617551 		-
- 0.0001 -
208_LEU ARG gnomAD
chr16:28603736 		rs200622719
- 0.000119293 -
211_VAL ALA 8.3kJPN
chr16:28617520 		rs750367684
- 0.0005 -
212_GLY ARG 8.3kJPN
chr16:28603725 		rs183030982
- 0.0008 -
213_ARG HIS gnomAD
chr16:28617514 		rs1042028
- 0.223702 -
213_ARG HIS 8.3kJPN
chr16:28617514 		rs1042028
- 0.1363 -
217_GLU TER 8.3kJPN
chr16:28603710 		rs138147609
- 0.0069 -
220_VAL MET gnomAD
chr16:28617494 		rs199630120
- 0.000266641 -
223_VAL MET gnomAD
chr16:28617485 		rs1801030
- 0.98036 -
223_VAL MET 8.3kJPN
chr16:28617485 		rs1801030
- 0.9999 -
225_GLU GLN 8.3kJPN
chr16:28603686 		rs1042041
- 0.0001 -
225_GLN GLU 8.3kJPN
chr16:28617479 		rs778104206
- 0.0002 -
226_HIS ASP gnomAD
chr16:28603683 		rs11569763
- 0.00119357 -
227_THR MET gnomAD
chr16:28617472 		rs150459557
- 0.0023894 -
227_THR PRO gnomAD
chr16:28617473 		rs552524124
- 0.000207887 -
227_THR PRO 8.3kJPN
chr16:28617473 		rs552524124
- 0.0011 -
234_LYS ASN gnomAD
chr16:30214933 		rs1328799050
- 0.000753448 -
235_ASN THR VAR_014889 rs35728980
LB/B - -
235_ASN THR gnomAD
chr16:28603655 		rs1059491
- 0.316783 -
235_ASN THR 8.3kJPN
chr16:28603655 		rs1059491
- 0.1372 -
238_THR ALA gnomAD
chr16:28603647 		rs751322432
- 0.000119417 -
239_ASN SER gnomAD
chr16:28603643 		rs45472392
- 0.00119424 -
241_THR SER 8.3kJPN
chr16:28617430 		-
- 0.0001 -
243_VAL ILE gnomAD
chr16:28617425 		rs200947432
- 0.000107568 -
244_ARG HIS 8.3kJPN
chr16:28603628 		rs145465524
- 0.0001 -
244_PRO ARG 8.3kJPN
chr16:28617421 		rs753810855
- 0.0002 -
245_ARG TRP 8.3kJPN
chr16:28603626 		rs1216099859
- 0.0001 -
247_PHE LEU gnomAD
chr16:28617413 		rs28374453
- 0.00409813 -
247_PHE LEU 8.3kJPN
chr16:28617413 		rs28374453
- 0.0005 -
258_LYS ASN 8.3kJPN
chr16:28603585 		rs55845129
- 0.0001 -
260_MET ILE gnomAD
chr16:29475788 		rs1259664605
- 0.00075188 -
266_THR ILE 8.3kJPN
chr16:28617233 		-
- 0.0001 -
268_PHE LEU gnomAD
chr16:28603433 		rs201751578
- 0.000151836 -
268_PHE LEU 8.3kJPN
chr16:28603433 		rs201751578
- 0.0011 -
270_VAL GLY gnomAD
chr16:28617221 		rs199923901
- 0.000293339 -
270_VAL MET gnomAD
chr16:28617222 		rs201219890
- 0.000301866 -
270_VAL GLY 8.3kJPN
chr16:28617221 		rs199923901
- 0.0001 -
270_VAL MET 8.3kJPN
chr16:28617222 		rs201219890
- 0.015 -
275_ARG CYS gnomAD
chr16:28617207 		rs375683981
- 0.000105083 -
275_ARG HIS gnomAD
chr16:30215177 		rs1269047233
- 0.000327225 -
275_ARG HIS 8.3kJPN
chr16:30215177 		rs1269047233
- 0.0003 -
280_TYR CYS 8.3kJPN
chr16:28603398 		-
- 0.0004 -
281_ALA GLU 8.3kJPN
chr16:28603395 		-
- 0.0001 -
281_ALA GLU 8.3kJPN
chr16:28617188 		-
- 0.0001 -
282_GLU LYS VAR_061886 rs36043491
LB/B - -
282_LYS GLU gnomAD
chr16:28603393 		rs27742
- 0.996067 -
290_SER GLY 8.3kJPN
chr16:30215221 		-
- 0.001 -
292_ARG CYS 8.3kJPN
chr16:28617156 		rs745498975
- - -
295_LEU PRO 8.3kJPN
chr16:30215237 		-
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.