PDB ID 2E5D     CHAIN A
Protein name Nicotinamide phosphoribosyltransferase
Uniprot Accession P43490
The number of similar proteins 175
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2E5D (CHAIN: A)
1 P43490  
2 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   GPLGSPQFMN   PAAEAEFNIL   LATDSYKVTH   YKQYPPNTSK   VYSYFECREK   50
51   KTENSKLRKV   KYEETVFYGL   QYILNKYLKG   KVVTKEKIQE   AKDVYKEHFQ   100
101   DDVFNEKGWN   YILEKYDGHL   PIEIKAVPEG   FVIPRGNVLF   TVENTDPECY   150
151   WLTNWIETIL   VQSWYPITVA   TNSREQKKIL   AKYLLETSGN   LDGLEYKLHD   200
201   FGYRGVSSQE   TAGIGASAHL   VNFKGTDTVA   GLALIKKYYG   TKDPVPGYSV   250
251   PAAEHSTITA   WGKDHEKDAF   EHIVTQFSSV   PVSVVSDSYD   IYNACEKIWG   300
301   EDLRHLIVSR   STQAPLIIRP   DSGNPLDTVL   KVLEILGKKF   PVTENSKGYK   350
351   LLPPYLRVIQ   GDGVDINTLQ   EIVEGMKQKM   WSIENIAFGS   GGGLLQKLTR   400
401   DLLNCSFKCS   YVVTNGLGIN   VFKDPVADPN   KRSKKGRLSL   HRTPAGNFVT   450
451   LEEGKGDLEE   YGQDLLHTVF   KNGKVTKSYS   FDEIRKNAQL   NIELEAAHH   500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
11_ILE VAL 8.3kJPN
chr7:105925300 		rs1209577193
- 0.0001 -
84_LYS ARG 8.3kJPN
chr7:105915459 		rs1361672762
- 0.0001 -
95_VAL ALA 8.3kJPN
chr7:105915426 		-
- 0.0001 -
176_LEU SER VAR_036614 -
US - A colorectal cancer sample
204_ALA GLY 8.3kJPN
chr7:105909042 		-
- 0.0001 -
226_LEU VAL 8.3kJPN
chr7:105908977 		rs1421696802
- 0.0001 -
260_ASP ASN 8.3kJPN
chr7:105904029 		rs1282405793
- 0.0002 -
440_PHE CYS 8.3kJPN
chr7:105893509 		-
- 0.0001 -
453_TYR HIS 8.3kJPN
chr7:105893471 		-
- 0.0001 -
475_GLU ALA gnomAD
chr7:105891581 		rs140819103
- 0.000143513 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.