PiSITE

PDB ID	2ERY	CHAIN	A
Protein name	Ras-related protein R-Ras2
Uniprot Accession	P62070
The number of similar proteins	1
The number of binding states	1
The number of binding partners	0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	2ERY (CHAIN: A)
1	Monomeric state

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Molecule viewer

Only interaction residues

#binding
partners

Sequence information

SMQEKYRLVV

VGGGGVGKSA

LTIQFIQSYF

VTDYDPTIED

SYTKQCVIDD

RAARLDILDT

AGQEEFGAMR

EQYMRTGEGF

LLVFSVTDRG

SFEEIYKFQR

100

101

QILRVKDRDE

FPMILIGNKA

DLDHQRQVTQ

EEGQQLARQL

KVTYMEASAK

150

151

IRMNVDQAFH

ELVRVIRKFQ

200

Variants

Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
23_GLY	VAL	VAR_083149	rs1591495779	LP/P	-	Noonan syndrome 12 (NS12) [MIM:618624]
23_GLY	VAL	ClinVar chr11:14380349	rs1591495779	Pathogenic	-	Noonan syndrome\|not provided [MONDO:MONDO:0018997,MeSH:D009634,MedGen:C0028326,OMIM:PS163950,Orphanet:648\|MedGen:CN517202]
23_GLY	CYS	ClinVar chr11:14380350	rs2134048726	Pathogenic/Likely pathogenic	-	not provided\|Noonan syndrome [MedGen:C3661900\|MONDO:MONDO:0018997,MeSH:D009634,MedGen:C0028326,OMIM:PS163950,Orphanet:648]
23_GLY	ASP	ClinVar chr11:14380349	rs1591495779	Pathogenic	-	Noonan syndrome 12\|not provided [MONDO:MONDO:0032839,MedGen:C5231432,OMIM:618624\|MedGen:C3661900]
24_GLY	ASP	ClinVar chr11:14380346	-	Likely pathogenic	-	not provided [MedGen:CN517202]
41_THR	MET	8.3kJPN chr11:14317388	rs782670869	-	0.0001	-
70_ALA	THR	VAR_083152	rs782457908	LP/P	-	Noonan syndrome 12 (NS12) [MIM:618624]
75_PHE	CYS	VAR_083154	-	US	-	-
98_ARG	LYS	8.3kJPN chr11:14316312	-	-	0.0003	-
105_TYR	CYS	8.3kJPN chr11:14316111	rs571234555	-	0.0002	-
117_ARG	HIS	8.3kJPN chr11:14316075	rs566703225	-	0.0001	-
138_THR	SER	gnomAD chr11:14303263	rs549966258	-	0.000606392	-
147_ARG	TRP	ClinVar chr11:14303236	-	Likely pathogenic	-	Noonan syndrome 12 [MONDO:MONDO:0032839,MedGen:C5231432,OMIM:618624]

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