PDB ID 2FJU     CHAIN B
Protein name 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2
Uniprot Accession Q00722
The number of similar proteins 2
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2FJU (CHAIN: B)
1 P63000  
2 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MSLLNPVLLP   PKVKAYLSQG   ERFIKWDDET   TVASPVILRV   DPKGYYLYWT   50
51   YQSKEMEFLD   ITSIRDTRFG   KFAKMPKSQK   LRDVFNMDFP   DNSFLLKTLT   100
101   VVSGPDMVDL   TFHNFVSYKE   NVGKAWAEDV   LALVKHPLTA   NASRSTFLDK   150
151   ILVKLKMQLN   SEGKIPVKNF   FQMFPADRKR   VEAALSACHL   PKGKNDAINP   200
201   EDFPEPVYKS   FLMSLCPRPE   IDEIFTSYHA   KAKPYMTKEH   LTKFINQKQR   250
251   DSRLNSLLFP   PARPDQVQGL   IDKYEPSGIN   AQRGQLSPEG   MVWFLCGPEN   300
301   SVLAQDKLLL   HHDMTQPLNH   YFINSSHNTY   LTAGQFSGLS   SAEMYRQVLL   350
351   SGCRCVELDC   WKGKPPDEEP   IITHGFTMTT   DIFFKEAIEA   IAESAFKTSP   400
401   YPIILSFENH   VDSPRQQAKM   AEYCRTIFGD   MLLTEPLEKF   PLKPGVPLPS   450
451   PEDLRGKILI   KNKKNQFSGP   TSSSKDTGGE   AEGSSPPSAP   AVWAGEEGTE   500
501   LEEEEVEEEE   EEESGNLDEE   EIKKMQSDEG   TAGLEVTAYE   EMSSLVNYIQ   550
551   PTKFVSFEFS   AQKNRSYVIS   SFTELKAYDL   LSKASVQFVD   YNKRQMSRIY   600
601   PKGTRMDSSN   YMPQMFWNAG   CQMVALNFQT   MDLPMQQNMA   VFEFNGQSGY   650
651   LLKHEFMRRP   DKQFNPFSVD   RIDVVVATTL   SITVISGQFL   SERSVRTYVE   700
701   VELFGLPGDP   KRRYRTKLSP   STNSINPVWK   EEPFVFEKIL   MPELASLRVA   750
751   VMEEGNKFLG   HRIIPINALN   SGYHHLCLHS   ESNMPLTMPA   LFIFLEMKD   800

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
39_ARG CYS 8.3kJPN
chr15:40596249 		rs920386791
- 0.0001 -
49_TRP ARG 8.3kJPN
chr15:40596219 		-
- 0.0001 -
63_SER ASN gnomAD
chr15:40595532 		rs202154132
- 0.000132272 -
67_THR ALA gnomAD
chr15:40595521 		rs758467165
- 0.000204401 -
84_VAL ILE gnomAD
chr15:40594792 		rs567578673
- 0.000424908 -
86_ASN LYS gnomAD
chr15:40594784 		rs57020474
- 0.000537031 -
86_ASN LYS 8.3kJPN
chr15:40594784 		rs57020474
- 0.0037 -
95_LEU ARG gnomAD
chr15:40594758 		rs199647108
- 0.000168322 -
111_THR PRO gnomAD
chr15:40594711 		rs754490555
- 0.000120656 -
116_VAL ILE 8.3kJPN
chr15:40594696 		rs1169218717
- 0.0001 -
120_GLU VAL 8.3kJPN
chr15:40594683 		-
- 0.0004 -
122_VAL MET 8.3kJPN
chr15:40594678 		rs760130831
- 0.0001 -
129_ASP GLU 8.3kJPN
chr15:40594536 		-
- 0.0001 -
166_PRO LEU gnomAD
chr15:40594346 		rs150110779
- 0.000877612 -
177_ASP GLU 8.3kJPN
chr15:40594209 		-
- 0.0001 -
178_ARG LEU 8.3kJPN
chr15:40594207 		-
- 0.0001 -
187_ALA SER gnomAD
chr15:40594181 		rs201088044
- 0.000741762 -
199_ASN LYS 8.3kJPN
chr15:40591415 		-
- 0.0001 -
209_LYS ASN 8.3kJPN
chr15:40591385 		-
- 0.0001 -
218_ARG GLN 8.3kJPN
chr15:40591359 		rs760528362
- 0.0004 -
237_THR MET 8.3kJPN
chr15:40591139 		rs1242886355
- 0.0001 -
247_GLN LYS 8.3kJPN
chr15:40591110 		-
- 0.0001 -
250_ARG PRO gnomAD
chr15:40591100 		rs199754432
- 0.000129735 -
298_PRO SER 8.3kJPN
chr15:40590868 		rs756911216
- 0.0004 -
302_VAL ALA 8.3kJPN
chr15:40590855 		-
- 0.0001 -
312_HIS GLN gnomAD
chr15:40590824 		rs114336069
- 0.00228016 -
317_PRO SER gnomAD
chr15:40590811 		rs372976059
- 0.000264472 -
317_PRO SER 8.3kJPN
chr15:40590811 		rs372976059
- 0.0008 -
324_ASN ILE VAR_047509 rs45628633
LB/B - -
325_SER LEU 8.3kJPN
chr15:40590786 		rs778331998
- 0.0005 -
341_SER LEU 8.3kJPN
chr15:40590557 		rs201305253
- 0.0001 -
349_LEU PRO 8.3kJPN
chr15:40590533 		rs748859449
- 0.0002 -
356_VAL MET 8.3kJPN
chr15:40590513 		rs190513619
- 0.0001 -
411_VAL ALA 8.3kJPN
chr15:40590084 		rs1271106196
- 0.0001 -
418_ALA THR 8.3kJPN
chr15:40589793 		-
- 0.0001 -
425_ARG GLN gnomAD
chr15:40589771 		rs200216697
- 0.000224528 -
425_ARG GLN 8.3kJPN
chr15:40589771 		rs200216697
- 0.0022 -
425_ARG TRP 8.3kJPN
chr15:40589772 		rs369261333
- 0.001 -
435_GLU LYS gnomAD
chr15:40589742 		rs186064001
- 0.00129071 -
441_PRO SER 8.3kJPN
chr15:40589724 		rs765646154
- 0.0004 -
454_LEU PHE 8.3kJPN
chr15:40589073 		-
- 0.0001 -
537_THR MET 8.3kJPN
chr15:40588571 		rs777681107
- 0.0001 -
551_PRO HIS 8.3kJPN
chr15:40588529 		-
- 0.0001 -
555_VAL ILE 8.3kJPN
chr15:40588518 		rs370423429
- 0.0001 -
557_PHE TYR gnomAD
chr15:40588511 		rs138547741
- 0.000225548 -
557_PHE TYR 8.3kJPN
chr15:40588511 		rs138547741
- - -
594_ARG HIS VAR_047510 rs8025153
LB/B - -
594_ARG HIS gnomAD
chr15:40587250 		rs8025153
- 0.000787439 -
658_ARG HIS 8.3kJPN
chr15:40586543 		rs538647274
- 0.0001 -
658_ARG CYS 8.3kJPN
chr15:40586544 		rs773166806
- 0.0001 -
660_PRO LEU gnomAD
chr15:40586537 		rs9972332
- 0.000188421 -
685_ILE PHE 8.3kJPN
chr15:40585922 		-
- 0.0001 -
708_GLY ARG VAR_047512 rs28395835
LB/B - -
727_PRO ALA 8.3kJPN
chr15:40585796 		-
- 0.0005 -
730_LYS ASN 8.3kJPN
chr15:40585785 		-
- 0.0001 -
773_TYR CYS gnomAD
chr15:40584641 		rs202225285
- 0.000984252 -
795_LEU PRO 8.3kJPN
chr15:40584575 		-
- 0.0001 -
796_GLU LYS 8.3kJPN
chr15:40584573 		rs778289490
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.