PDB ID 2FLP     CHAIN A
Protein name DNA polymerase iota
Uniprot Accession Q9UNA4
The number of similar proteins 41
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2FLP (CHAIN: A)
1 Monomeric state
2 Q9UNA4  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MELADVGAAA   SSQGVHDQVL   PTPNASSRVI   VHVDLDCFYA   QVEMISNPEL   50
51   KDKPLGVQQK   YLVVTCNYEA   RKLGVKKLMN   VRDAKEKCPQ   LVLVNGEDLT   100
101   RYREMSYKVT   ELLEEFSPVV   ERLGFDENFV   DLTEMVEKRL   QQLQSDELSA   150
151   VTVSGHVYNN   QSINLLDVLH   IRLLVGSQIA   AEMREAMYNQ   LGLTGCAGVA   200
201   SNKLLAKLVS   GVFKPNQQTV   LLPESCQHLI   HSLNHIKEIP   GIGYKTAKCL   250
251   EALGINSVRD   LQTFSPKILE   KELGISVAQR   IQKLSFGEDN   SPVILSGPPQ   300
301   SFSEEDSFKK   CSSEVEAKNK   IEELLASLLN   RVCQDGRKPH   TVRLIIRRYS   350
351   SEKHYGRESR   QCPIPSHVIQ   KLGTGNYDVM   TPMVDILMKL   FRNMVNVKMP   400
401   FHLTLLSVCF   CNLKALNTAK         450

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
44_MET VAL 8.3kJPN
chr18:51797819
-
- 0.0001 -
71_ARG GLY VAR_021239 rs3218778
LB/B - -
90_GLN TER 8.3kJPN
chr18:51800397
rs1321388648
- 0.0001 -
92_VAL ILE gnomAD
chr18:51800403
rs142974796
- 0.000171961 -
92_VAL ILE 8.3kJPN
chr18:51800403
rs142974796
- 0.0047 -
105_MET VAL 8.3kJPN
chr18:51800442
rs151128120
- 0.0004 -
106_SER PRO 8.3kJPN
chr18:51800445
-
- 0.0001 -
111_GLU LYS 8.3kJPN
chr18:51800460
rs1487952694
- 0.0001 -
130_VAL MET 8.3kJPN
chr18:51804129
rs1373913311
- 0.0001 -
150_ALA VAL 8.3kJPN
chr18:51804190
rs140298800
- 0.0001 -
162_SER PRO 8.3kJPN
chr18:51804225
-
- 0.0001 -
182_GLU ASP 8.3kJPN
chr18:51807098
-
- 0.0001 -
236_ILE MET VAR_021240 rs3218784
LB/B - -
236_ILE MET gnomAD
chr18:51807260
rs3218784
- 0.0189909 -
251_GLU LYS VAR_021241 rs3218783
LB/B - -
251_GLU LYS gnomAD
chr18:51809236
rs3218783
- 0.000739335 -
259_ARG HIS gnomAD
chr18:51809261
rs201346546
- 0.000235484 -
260_ASP GLY gnomAD
chr18:51809264
rs200692792
- 0.000146251 -
264_PHE LEU gnomAD
chr18:51809277
rs143700892
- 0.000901766 -
289_ASP GLY 8.3kJPN
chr18:51809351
rs199780326
- 0.0001 -
290_ASN ASP gnomAD
chr18:51809353
rs112212191
- 0.000257913 -
313_SER PHE 8.3kJPN
chr18:51810329
-
- 0.0001 -
336_GLY TER 8.3kJPN
chr18:51813664
-
- 0.0008 -
340_HIS PRO 8.3kJPN
chr18:51813677
rs777178383
- 0.0001 -
349_TYR TER 8.3kJPN
chr18:51813705
-
- 0.0001 -
355_TYR ASN 8.3kJPN
chr18:51813721
rs756150056
- 0.0001 -
357_ARG CYS 8.3kJPN
chr18:51813727
rs149914424
- 0.0001 -
360_ARG CYS gnomAD
chr18:51813736
rs371876172
- 0.000120407 -
360_ARG HIS 8.3kJPN
chr18:51813737
rs923910739
- 0.0002 -
365_PRO ARG gnomAD
chr18:51813752
rs200852409
- 0.000340256 -
380_MET VAL 8.3kJPN
chr18:51818217
-
- 0.0002 -
381_THR ASN gnomAD
chr18:51818221
rs756576246
- 0.000220349 -
383_MET VAL 8.3kJPN
chr18:51818226
rs759284982
- 0.0001 -
388_MET THR 8.3kJPN
chr18:51818242
rs148677085
- 0.0001 -
394_MET VAL gnomAD
chr18:51818259
rs142168361
- 0.00149249 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.