PDB ID 2FM0     CHAIN A
Protein name cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Uniprot Accession Q08499
The number of similar proteins 161
The number of binding states 5
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2FM0 (CHAIN: A)
1 Q08499   Q08499   Q08499  
2 Monomeric state
3 Q08499  
4 Q08499   Q08499  
5 Q08499   Q08499   Q08499   Q08499  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   IPRFGVKTEQ   EDVLAKELED   VNKWGLHVFR   IAELSGNRPL   TVIMHTIFQE   50
51   RDLLKTFKIP   VDTLITYLMT   LEDHYHADVA   YHNNIHAADV   VQSTHVLLST   100
101   PALEAVFTDL   EILAAIFASA   IHDVDHPGVS   NQFLINTNSE   LALMYNDSSV   150
151   LENHHLAVGF   KLLQEENCDI   FQNLTKKQRQ   SLRKMVIDIV   LATDMSKHMN   200
201   LLADLKTMVE   TKKVTSSGVL   LLDNYSDRIQ   VLQNMVHCAD   LSNPTKPLQL   250
251   YRQWTDRIME   EFFRQGDRER   ERGMEISPMC   DKHNASVEKS   QVGFIDYIVH   300
301   PLWETWADLV   HPDAQDILDT   LEDNREWYQS   TIPQSPSPAP   DDPEEGRQGQ   350
351   TEKFQFELTL   E         400

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
80_PRO ALA gnomAD
chr19:18330088
rs147234546
- 0.00218452 -
81_ARG HIS gnomAD
chr19:18330084
rs555152018
- 0.000911109 -
81_ARG GLN 8.3kJPN
chr19:10568738
rs1269711202
- 0.0002 -
81_ARG HIS 8.3kJPN
chr19:18330084
rs555152018
- 0.0001 -
85_LYS MET 8.3kJPN
chr19:10568750
-
- 0.0001 -
87_ASP TYR 8.3kJPN
chr19:10568755
-
- 0.0001 -
108_ASN SER 8.3kJPN
chr1:66828891
-
- 0.0001 -
110_ALA VAL 8.3kJPN
chr19:18329802
rs772270728
- 0.0001 -
116_ARG GLN gnomAD
chr19:18329784
rs2229228
- 0.290054 -
116_ARG TRP gnomAD
chr19:18329785
rs11879710
- 0.00571006 -
116_ARG GLN 8.3kJPN
chr19:18329784
rs2229228
- 0.1442 -
136_ARG CYS gnomAD
chr19:10570295
rs201196140
- 0.000103517 -
146_MET ILE 8.3kJPN
chr19:10570327
-
- 0.0001 -
151_ASP GLY 8.3kJPN
chr1:66829160
-
- 0.0001 -
155_ALA THR 8.3kJPN
chr19:10570352
rs183936414
- 0.0007 -
156_ASN SER gnomAD
chr19:18329223
rs113176090
- 0.000111362 -
157_VAL MET 8.3kJPN
chr19:10570358
-
- 0.0001 -
162_SER ARG gnomAD
chr1:66829194
rs146166974
- 0.000195553 -
169_ALA VAL 8.3kJPN
chr1:66829214
-
- 0.0001 -
178_THR ALA 8.3kJPN
chr19:18329158
-
- 0.0001 -
204_HIS ARG 8.3kJPN
chr19:18328994
-
- 0.0001 -
216_ASN ASP 8.3kJPN
chr19:18328959
-
- 0.0001 -
217_SER PRO 8.3kJPN
chr5:58273170
-
- 0.0001 -
239_LYS ARG gnomAD
chr19:10572271
rs141379029
- 0.000369887 -
257_ARG TRP gnomAD
chr19:10572324
rs146986676
- 0.00040994 -
267_MET LEU 8.3kJPN
chr19:10572354
rs776679347
- 0.0002 -
285_THR PRO VAR_068245 rs397514467
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
285_THR PRO ClinVar
chr5:58272248
rs397514467
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
288_GLU ALA VAR_069453 -
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
293_THR PRO ClinVar
chr5:58272224
rs2153305991
Likely pathogenic - not provided [MedGen:C3661900]
303_TYR CYS ClinVar
chr5:58272193
rs1554033904
Likely pathogenic - not provided [MedGen:CN517202]
305_ASP ASN 8.3kJPN
chr1:66833737
rs749156051
- 0.0001 -
306_ARG GLN gnomAD
chr19:18324185
rs371170617
- 0.00034246 -
311_ARG GLN gnomAD
chr19:10574476
rs200669683
- 0.000234837 -
319_LEU VAL 8.3kJPN
chr19:18322721
-
- 0.0001 -
321_ASN THR 8.3kJPN
chr19:10574506
rs758029716
- 0.0005 -
323_THR PRO 8.3kJPN
chr19:10574511
rs1221315322
- 0.0011 -
325_PRO LEU gnomAD
chr19:18322702
rs149614671
- 0.000242628 -
325_PRO LEU 8.3kJPN
chr19:18322702
rs149614671
- 0.0005 -
334_ASP GLU gnomAD
chr1:66834547
rs141437989
- 0.000422873 -
334_ASP GLU 8.3kJPN
chr1:66834547
rs141437989
- 0.0001 -
335_ARG TRP 8.3kJPN
chr5:58271588
rs775209507
- 0.0001 -
342_ARG CYS gnomAD
chr5:58271567
rs371950648
- 0.000112275 -
348_ARG TRP 8.3kJPN
chr1:66834587
rs201667673
- 0.0001 -
348_ARG HIS 8.3kJPN
chr19:10574587
rs373223236
- 0.0002 -
349_GLU ALA ClinVar
chr5:58271545
rs387906744
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
352_LEU PRO 8.3kJPN
chr19:18322621
-
- 0.0001 -
357_MET ILE 8.3kJPN
chr19:10574615
rs1340115666
- 0.0001 -
363_ALA PRO 8.3kJPN
chr19:10574631
-
- 0.0001 -
371_GLY ASP VAR_069454 rs397514469
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
371_GLY ASP ClinVar
chr5:58270903
rs397514469
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
376_ILE THR VAR_069455 rs587777188
LP/P - Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]
376_ILE THR ClinVar
chr5:58270888
rs587777188
Pathogenic - Acrodysostosis 2 with or without hormone resistance|not provided [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651|MedGen:C3661900]
376_ILE THR 8.3kJPN
chr19:18322067
-
- 0.0001 -
382_GLU GLY ClinVar
chr5:58270870
rs1743358464
Likely pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
388_VAL ILE 8.3kJPN
chr5:58270853
rs192644692
- 0.0001 -
394_GLU LYS 8.3kJPN
chr19:10577635
-
- 0.0001 -
398_THR SER 8.3kJPN
chr1:66838080
rs779182342
- 0.0003 -
407_GLN HIS 8.3kJPN
chr5:58270794
-
- 0.0001 -
411_ARG GLN gnomAD
chr19:10577687
rs146370645
- 0.00111828 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.