PDB ID 2FN4 CHAINA
Protein nameRAS-RELATED PROTEIN R-RAS
Uniprot Accession P10301
The number of similar proteins 1
The number of binding states 1
The number of binding partners 0
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
2FN4 (CHAIN: A)
1 Monomeric state
Downdload
Format:
Molecule viewer
#binding
partners
  0
Sequence information
1  SMDPPPSETH   KLVVVGGGGV   GKSALTIQFI   QSYFVSDYDP   TIEDSYTKIC   50
51  SVDGIPARLD   ILDTAGQEEF   GAMREQYMRA   GHGFLLVFAI   NDRQSFNEVG   100
101  KLFTQILRVK   DRDDFPVVLV   GNKADLESQR   QVPRSEASAF   GASHHVAYFE   150
151  ASAKLRLNVD   EAFEQLVRAV   RKYQEQELPP   S                      200
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
43_SER THR ClinVar rs869025189 Pathogenic Noonan syndrome;Noonan syndrome 8;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202]
59_ASP TYR ClinVar rs869025190 Likely pathogenic Noonan syndrome [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006]
85_ALA PRO ClinVar rs869025191 Pathogenic/Likely pathogenic Noonan syndrome;Noonan syndrome 8 [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355]
85_ALA THR ClinVar rs869025191 Pathogenic/Likely pathogenic Noonan syndrome;Noonan syndrome 8;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202]
89_GLU GLY ClinVar rs869025193 Pathogenic Noonan syndrome;Noonan syndrome 8;not provided;not specified [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202; MedGen:CN169374]
89_GLU GLN ClinVar rs869025192 Pathogenic Noonan syndrome [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006]
90_PHE LEU ClinVar rs730881014 Pathogenic Noonan syndrome;Noonan syndrome 8;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202]
90_PHE LEU ClinVar rs730881014 Pathogenic Noonan syndrome 8;not provided [MedGen:C3809233, OMIM:615355; MedGen:CN517202]
90_PHE CYS ClinVar rs868208063 Pathogenic not provided [MedGen:CN517202]
90_PHE VAL ClinVar rs869025194 Pathogenic Noonan syndrome;Noonan syndrome 8;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202]
90_PHE LEU ClinVar rs869025194 Pathogenic Noonan syndrome;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:CN517202]
92_ALA VAL ClinVar rs869025196 Likely pathogenic Noonan syndrome;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:CN517202]
97_TYR HIS ClinVar rs869025197 Pathogenic Noonan syndrome;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:CN517202]
98_MET ILE ClinVar rs483352822 Pathogenic not provided [MedGen:CN517202]
98_MET ILE ClinVar rs483352822 Pathogenic Noonan syndrome 8;not provided [MedGen:C3809233, OMIM:615355; MedGen:CN517202]
98_MET ILE ClinVar rs483352822 Pathogenic Noonan syndrome;Noonan syndrome 8;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202]
103_GLY ALA ClinVar rs672601335 Pathogenic Noonan syndrome;Noonan syndrome 8;not provided [MeSH:D009634, MedGen:C0028326, Orphanet:ORPHA648, SNOMED CT:205824006; MedGen:C3809233, OMIM:615355; MedGen:CN517202]