PDB ID 2G77     CHAIN B
Protein name Ras-related protein Rab-33B
Uniprot Accession O35963
The number of similar proteins 8
The number of binding states 3
The number of binding partners 2

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2G77 (CHAIN: B)
1 Q08484  
2 Monomeric state
3 Q8C0J2   Q8C0J2  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   MGHHHHHHGS   SSCAVSGASG   CLPPARSRIF   KIIVIGDSNV   GKTCLTYRFC   50
51   AGRFPDRTEA   TIGVDFRERA   VDIDGERIKI   QLWDTAGQER   FRKSMVQHYY   100
101   RNVHAVVFVY   DXTNXASFHS   LPAWIEECKQ   HLLANDIPRI   LVGNKCDLRS   150
151   AIQVPTDLAQ   KFADTHSXPL   FETSAKNPND   NDHVEAIFXT   LAHKLKSH   200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
35_LYS GLU 8.3kJPN
chr4:140375452 		-
- 0.0001 -
43_ASN SER gnomAD
chr4:140375477 		rs371561776
- 0.000254808 -
46_LYS GLN ClinVar
chr4:140375485 		rs587776958
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
48_CYS TER ClinVar
chr4:140375493 		rs2111067418
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
71_ARG TER ClinVar
chr4:140375560 		rs1085307128
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
74_ALA VAL 8.3kJPN
chr4:140375570 		rs1267179477
- 0.0001 -
77_ILE MET gnomAD
chr4:140375580 		rs202128260
- 0.000497058 -
85_GLN TER ClinVar
chr4:140393843 		rs2111087458
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
94_ARG TER ClinVar
chr4:140393870 		rs1187861686
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
113_VAL MET gnomAD
chr4:140393927 		rs150536664
- 0.000131314 -
113_VAL LEU 8.3kJPN
chr4:140393927 		-
- 0.0001 -
134_GLN TER ClinVar
chr4:140393990 		rs1750416123
Pathogenic - Smith-McCort dysplasia 2|Skeletal dysplasia [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222|Human Phenotype Ontology:HP:0002652,Human Phenotype Ontology:HP:0005685,MONDO:MONDO:0018230,MedGen:C0410528,Orphanet:364526]
148_ASN LYS ClinVar
chr4:140394034 		rs886044716
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
164_GLN TER ClinVar
chr4:140394080 		rs1085307131
Pathogenic - Smith-McCort dysplasia 2 [MONDO:MONDO:0014087,MedGen:C3714896,OMIM:615222]
177_THR MET gnomAD
chr4:140394120 		rs140381459
- 0.00155561 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.