PDB ID 2GVG     CHAIN A
Protein name Nicotinamide phosphoribosyltransferase
Uniprot Accession P43490
The number of similar proteins 175
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2GVG (CHAIN: A)
1 P43490  
2 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MNPAAEAEFN   ILLATDSYKV   THYKQYPPNT   SKVYSYFECR   EKKTENSKLR   50
51   KVKYEETVFY   GLQYILNKYL   KGKVVTKEKI   QEAKDVYKEH   FQDDVFNEKG   100
101   WNYILEKYDG   HLPIEIKAVP   EGFVIPRGNV   LFTVENTDPE   CYWLTNWIET   150
151   ILVQSWYPIT   VATNSREQKK   ILAKYLLETS   GNLDGLEYKL   HDFGYRGVSS   200
201   QETAGIGASA   HLVNFKGTDT   VAGLALIKKY   YGTKDPVPGY   SVPAAEHSTI   250
251   TAWGKDHEKD   AFEHIVTQFS   SVPVSVVSDS   YDIYNACEKI   WGEDLRHLIV   300
301   SRSTQAPLII   RPDSGNPLDT   VLKVLEILGK   KFPVTENSKG   YKLLPPYLRV   350
351   IQGDGVDINT   LQEIVEGMKQ   KMWSIENIAF   GSGGGLLQKL   TRDLLNCSFK   400
401   CSYVVTNGLG   INVFKDPVAD   PNKRSKKGRL   SLHRTPAGNF   VTLEEGKGDL   450
451   EEYGQDLLHT   VFKNGKVTKS   YSFDEIRKNA   QLNIELEAAH   H   500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
11_ILE VAL 8.3kJPN
chr7:105925300 		rs1209577193
- 0.0001 -
84_LYS ARG 8.3kJPN
chr7:105915459 		rs1361672762
- 0.0001 -
95_VAL ALA 8.3kJPN
chr7:105915426 		-
- 0.0001 -
176_LEU SER VAR_036614 -
US - A colorectal cancer sample
204_ALA GLY 8.3kJPN
chr7:105909042 		-
- 0.0001 -
226_LEU VAL 8.3kJPN
chr7:105908977 		rs1421696802
- 0.0001 -
260_ASP ASN 8.3kJPN
chr7:105904029 		rs1282405793
- 0.0002 -
440_PHE CYS 8.3kJPN
chr7:105893509 		-
- 0.0001 -
453_TYR HIS 8.3kJPN
chr7:105893471 		-
- 0.0001 -
475_GLU ALA gnomAD
chr7:105891581 		rs140819103
- 0.000143513 -
484_ILE THR gnomAD
chr7:105891554 		rs202025145
- 0.000769519 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.