PDB ID 2GVJ     CHAIN A
Protein name Nicotinamide phosphoribosyltransferase
Uniprot Accession P43490
The number of similar proteins 175
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2GVJ (CHAIN: A)
1 P43490  
2 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   NPAAEAEFNI   LLATDSYKVT   HYKQYPPNTS   KVYSYFECRE   KKTENSKLRK   50
51   VKYEETVFYG   LQYILNKYLK   GKVVTKEKIQ   EAKDVYKEHF   QDDVFNEKGW   100
101   NYILEKYDGH   LPIEIKAVPE   GFVIPRGNVL   FTVENTDPEC   YWLTNWIETI   150
151   LVQSWYPITV   ATNSREQKKI   LAKYLLETSG   NLDGLEYKLH   DFGYRGVSSQ   200
201   ETAGIGASAH   LVNFKGTDTV   AGLALIKKYY   GTKDPVPGYS   VPAAEHSTIT   250
251   AWGKDHEKDA   FEHIVTQFSS   VPVSVVSDSY   DIYNACEKIW   GEDLRHLIVS   300
301   RSTQAPLIIR   PDSGNPLDTV   LKVLEILGKK   FPVTENSKGY   KLLPPYLRVI   350
351   QGDGVDINTL   QEIVEGXKQK   XWSIENIAFG   SGGGLLQKLT   RDLLNCSFKC   400
401   SYVVTNGLGI   NVFKDPVADP   NKRSKKGRLS   LHRTPAGNFV   TLEEGKGDLE   450
451   EYGQDLLHTV   FKNGKVTKSY   SFDEIRKNAQ   LNIELEAAHH     500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
11_ILE VAL 8.3kJPN
chr7:105925300 		rs1209577193
- 0.0001 -
84_LYS ARG 8.3kJPN
chr7:105915459 		rs1361672762
- 0.0001 -
95_VAL ALA 8.3kJPN
chr7:105915426 		-
- 0.0001 -
176_LEU SER VAR_036614 -
US - A colorectal cancer sample
204_ALA GLY 8.3kJPN
chr7:105909042 		-
- 0.0001 -
226_LEU VAL 8.3kJPN
chr7:105908977 		rs1421696802
- 0.0001 -
260_ASP ASN 8.3kJPN
chr7:105904029 		rs1282405793
- 0.0002 -
440_PHE CYS 8.3kJPN
chr7:105893509 		-
- 0.0001 -
453_TYR HIS 8.3kJPN
chr7:105893471 		-
- 0.0001 -
475_GLU ALA gnomAD
chr7:105891581 		rs140819103
- 0.000143513 -
484_ILE THR gnomAD
chr7:105891554 		rs202025145
- 0.000769519 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.